9 results match your criteria: "University of Southern California-University of California[Affiliation]"
18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
Anesthesiology
April 2018
From the Department of Anesthesiology (R.Y.K., T.B., M.B., N.T., M.F.N., J.P.M.), Department of Radiology (O.G.J., S.B.-N.), Department of Biostatistics and Bioinformatics (Y.-J.L., W.Q.), and the Department of Psychiatry and Behavioral Science (P.M.D.), Duke University, Durham, North Carolina. University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Mayo Clinic, Rochester University of California, Berkeley University of Pennsylvania University of Southern California University of California, Davis Brigham and Women's Hospital/Harvard Medical School Indiana University Washington University St. Louis University of Pennsylvania Prevent Alzheimer's Disease 2020 (Chair) Siemens Alzheimer's Association University of Pittsburgh Washington University St. Louis Cornell University Albert Einstein College of Medicine of Yeshiva University AD Drug Discovery Foundation Acumen Pharmaceuticals Washington University St. Louis Northwestern University National Institute of Mental Health Brown University Eli Lilly (Chair) BWH/HMS (Chair) University of Washington (Chair) Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, Davis (Core Principal Investigator) University of California, Davis University of California, San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester University of London University of California, Los Angeles School of Medicine University of California, San Francisco Magnetic Resonance Imaging University of California, Davis Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic University of California, Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute University of Pittsburgh University of California, Berkeley Washington University St. Louis Washington University St. Louis Washington University St. Louis Washington University St. Louis (ASCP) - Past Investigator University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco University of California, San Diego Prevent Alzheimer's Disease 2020 University of California, San Diego National Institute on Aging University of California, San Francisco Brown University National Institute of Mental Health Cornell University Johns Hopkins University Richard Frank Consulting Prevent Alzheimer's Disease 2020 National Institute on Aging Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University University of Southern California University of Southern California University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of Michigan University of Michigan Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham Mount Sinai School of Medicine Mount Sinai School of Medicine Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Johns Hopkins University Johns Hopkins University Johns Hopkins University Johns Hopkins University New York University New York University New York University New York University Duke University Medical Center Duke University Medical Center Duke University Medical Center University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Pittsburgh University of Pittsburgh University of Pittsburgh University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine University of Texas Southwestern Medical School University of Texas Southwestern Medical School University of Texas Southwestern Medical School Emory University Emory University Emory University University of Kansas, Medical Center University of Kansas, Medical Center University of Kansas, Medical Center University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Indiana University Indiana University Indiana University Indiana University Indiana University Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cleveland Clinic Lou Ruvo Center for Brain Health Cleveland Clinic Lou Ruvo Center for Brain Health Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Premiere Research Inst (Palm Beach Neurology) Premiere Research Inst (Palm Beach Neurology) Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Stanford University Stanford University Stanford University Stanford University Stanford University Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Boston University Boston University Boston University Boston University Boston University Howard University Howard University Howard University Case Western Reserve University Case Western Reserve University Case Western Reserve University Case Western Reserve University University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento Neurological Care of CNY Parkwood Hospital Parkwood Hospital Parkwood Hospital University of Wisconsin University of Wisconsin University of Wisconsin University of California, Irvine - BIC University of California, Irvine - BIC University of California, Irvine - BIC Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Dent Neurologic Institute Dent Neurologic Institute Dent Neurologic Institute Ohio State University Ohio State University Ohio State University Albany Medical College Albany Medical College Albany Medical College Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Rhode Island Hospital Rhode Island Hospital Rhode Island Hospital Butler Hospital Butler Hospital Butler Hospital UC San Francisco UC San Francisco UC San Francisco Medical University South Carolina Medical University South Carolina Medical University South Carolina St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care Nathan Kline Institute Nathan Kline Institute Nathan Kline Institute University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine Cornell University Cornell University Cornell University Cornell University University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Brigham and Women's Hospital/ Harvard Medical School University of California, Davis Mayo Clinic, Rochester University of California, Berkeley Washington University St. Louis Indiana University Perelman School of Medicine, University of Pennsylvania University of Southern California Perelman School of Medicine, University of Pennsylvania University of California, San Francisco Rehabilitation Institute of Chicago, Feinberg School of Medicine, Northwestern University University of Washington (Chair) Core Principal Investigator Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Francisco University of California, San Francisco University of California, San Francisco Neylan Davis (Core Principal Investigator) Neylan San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Senjem Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute Senjem Berkeley Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco Department of Defense (retired) University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Rush University Medical Center Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Duke University Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine Medical University South Carolina Medical University South Carolina Medical University South Carolina Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) University of California, San Francisco University of California, San Francisco University of California, San Francisco University of California, San Francisco Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Howard University Howard University Howard University University of Wisconsin University of Wisconsin University of Wisconsin University of Washington University of Washington University of Washington Stanford University Stanford University Stanford University Stanford University Cornell University Cornell University Cornell University.
Background: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively.
Methods: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9).
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.
Carcinogenesis
February 2012
Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California-University of California, Los Angeles, CA 90033, USA.
Chronic inflammation is an underlying risk factor for colon cancer. Tumor necrosis factor alpha (TNF-α) plays a critical role in the development of inflammation-induced colon cancer in a mouse model. S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) can inhibit lipopolysaccharide-induced TNF-α expression in macrophages.
View Article and Find Full Text PDFAbnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis.
Alcohol Clin Exp Res
January 2004
Division of Gastroenterology and Liver Diseases, University of Southern California Liver Disease Research Center, University of Southern California/University of California, USA.
Background: Abnormal methionine metabolism occurs in animals fed ethanol and in end-stage cirrhotic patients. Expected consequences of these abnormalities include reduced hepatic S-adenosylmethionine and glutathione (GSH) levels, impaired transmethylation, and reduced homocysteine catabolism, resulting in the often-observed hyperhomocystinemia in cirrhotic patients. These parameters have not been examined simultaneously in patients with less advanced alcoholic liver disease.
View Article and Find Full Text PDFNonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas.
Gastroenterology
December 2003
University of Southern California-University of California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA.
Background & Aims: The mechanisms involved in ethanol-induced pancreas fibrosis are poorly understood. Here we show that fatty acid ethyl esters (FAEEs), nonoxidative ethanol metabolites, increase extracellular matrix (ECM) protein levels in pancreas.
Methods: Rat pancreatic acini were incubated for 1-4 hours with FAEEs or acetaldehyde.
Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county.
Alcohol Clin Exp Res
November 2003
Department of Pathology, University of Southern California/University of California-Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, 90033, USA.
Background: This study sought to identify demographic characteristics of hospitalized patients with alcoholic liver disease (ALD) in Los Angeles County for the purpose of implementing new preventive and educational programs. Another specific aim of the study was to characterize demographic and comorbid differences between patients with ALD and patients with pancreatitis, another alcohol-related disease.
Methods: Analyses were performed on discharge data from all nonfederal short-stay hospitals within Los Angeles County, released for the year 1999 by the Office of Statewide Health Planning and Development.
Mechanism of staurosporine-induced apoptosis in murine hepatocytes.
Am J Physiol Gastrointest Liver Physiol
May 2002
University of Southern California Research Center for Liver Diseases, University of Southern California/University of California at Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, 90033, USA.
Article Synopsis
- Staurosporine (STS) triggers apoptosis in different cell types, but primary mouse hepatocytes show lower sensitivity than Jurkat and Huh-7 cells.
- While caspase-3 is activated in hepatocytes exposed to STS, this activation occurs independently of caspases-8, -9, and -12, indicating a unique apoptotic pathway.
- STS also increases hepatocyte vulnerability to tumor necrosis factor-alpha-induced apoptosis and affects NF-kappa B signaling, highlighting its complex role in liver cell death regulation.
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Proc Natl Acad Sci U S A
May 2001
Liver Disease Research Center, Research Center for Alcoholic Liver and Pancreatic Diseases, University of Southern California-University of California, Los Angeles, CA 90033, USA.
Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. Mature liver expresses MAT1A, whereas MAT2A is expressed in extrahepatic tissues and is induced during liver growth and dedifferentiation. To examine the influence of MAT1A on hepatic growth, we studied the effects of a targeted disruption of the murine MAT1A gene.
View Article and Find Full Text PDFChanges in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver.
Am J Physiol Gastrointest Liver Physiol
July 2000
Division of Gastrointestinal and Liver Diseases, University of Southern California-University of California, Los Angeles 90033, USA.
Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM). We previously showed that MAT2A expression was associated with more rapid cell growth. Changes in MAT expression have not been examined in animal models of alcoholic liver injury, which is the focus of the current study.
View Article and Find Full Text PDF