3 results match your criteria: "University of Southern CA Keck School of Medicine[Affiliation]"

Background: In newborns with hypoxic-ischemic encephalopathy (HIE), the correlation between neonatal neuroimaging and the degree of neurodevelopmental impairment (NDI) is unclear.

Methods: Infants with HIE enrolled in a randomized controlled trial underwent neonatal MRI/MR spectroscopy (MRS) using a harmonized protocol at 4-6 days of age. The severity of brain injury was measured with a validated scoring system.

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Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.

DNA Repair (Amst)

February 2016

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China. Electronic address:

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

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