3 results match your criteria: "University of South China. Electronic address: huwei_abc970642@163.com.[Affiliation]"
Adrenomedullin gene delivery rescues estrogen production in Leydig cells via the inhibition of TGF-β1/Smads signaling pathway.
Reprod Toxicol
January 2025
Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China. Electronic address:
Article Synopsis
- The study investigates adrenomedullin's (ADM) role in protecting estrogen production in Leydig cells by targeting the TGF-β1/Smads signaling pathway.
- Treatment with ADM via recombinant adenovirus (Ad-ADM) in Leydig cells improved cell viability and hormone production in the presence of lipopolysaccharide (LPS), a compound that can induce cellular stress.
- Results indicated that Ad-ADM not only maintained testosterone production and aromatase activity but also reduced the harmful effects of TGF-β1 and Smads, suggesting that ADM supports the overall hormone balance in Leydig cells.
Anti-apoptotic effect of adrenomedullin gene delivery on Leydig cells by suppressing TGF-β1 via the Hippo signaling pathway.
Reprod Toxicol
August 2023
Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China. Electronic address:
Article Synopsis
- This study investigates how adrenomedullin (ADM) can restore the function of Leydig cells, which produce testosterone, by inhibiting the harmful effects of transforming growth factor-β1 (TGF-β1) through the Hippo signaling pathway.
- Experiments were conducted on primary Leydig cells treated with various agents, showing that ADM and TGF-β1-shRNA both protected against cell damage caused by lipopolysaccharide (LPS) and maintained testosterone production by regulating steroidogenic enzymes.
- The findings suggest that ADM not only prevents cell death but also improves steroid hormone synthesis by suppressing TGF-β1, highlighting its potential therapeutic role in maintaining Leydig cell functions.
Genetically-modified bone mesenchymal stem cells with TGF-β improve wound healing and reduce scar tissue formation in a rabbit model.
Exp Cell Res
June 2018
Wake Forest Institute for Regenerative Medicine, Wake Forest University, NC, USA. Electronic address:
Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model.
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