Perioperative immunotherapy plus chemotherapy versus chemotherapy alone for patients with resectable pulmonary lymphoepithelioma-like carcinoma.

Background: Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare subtype of non-small-cell lung cancer. This study aims to compare the efficacy and safety of perioperative PD-1/PD-L1 inhibitor plus chemotherapy versus chemotherapy alone in stage II-IIIB PLELC patients.

Patients And Methods: This retrospective study included stage II-IIIB PLELC patients.

LED illumination-assisted Activation of Peroxydisulfate by Heterogeneous CuS under Alkaline Condition for Efficient Organic Pollutants Removal.

The copper-based materials were considered as promising catalysts for the activation of peroxydisulfate (PDS), but the study on the CuS-activated PDS under LED illumination and alkaline condition was little reported. In this work, CuS, a simple and readily available heterogeneous catalyst, was employed to enhance the activation of PDS under alkaline condition through LED illumination. The results indicated that under LED illumination, the degradation rate of tetracycline (TC) during the first 15 min was 3.

Adaptive fusion of dual-view for grading prostate cancer.

Accurate preoperative grading of prostate cancer is crucial for assisted diagnosis. Multi-parametric magnetic resonance imaging (MRI) is a commonly used non-invasive approach, however, the interpretation of MRI images is still subject to significant subjectivity due to variations in physicians' expertise and experience. To achieve accurate, non-invasive, and efficient grading of prostate cancer, this paper proposes a deep learning method that adaptively fuses dual-view MRI images.

Effects of orally exposed SiO nanoparticles on lipid profiles in gut-liver axis of mice.

Recently we proposed the possibility of orally exposed nanoparticles (NPs) to alter metabolite homeostasis by changing metabolism pathways, in addition to intestinal damages, but relatively few studies investigated the changes of metabolite profiles in multi-organs. This study investigated the influences of orally exposed SiO NPs on lipid profiles in gut-liver axis. To this end, we treated mice with 16, 160 or 1600 mg/kg bodyweight SiO NPs via intragastric route.

Generation of INS-jGCaMP7f knock-in Ca reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting.

As a member of the single-fluorophore genetically encoded calcium indicators (GECIs), jGCaMP7f is widely applied to investigate intracellular Ca concentrations. Here, we established an INS-jGCaMP7f knock-in H1 human embryonic stem cell (hESC) line by integrating jGCaMP7f gene into insulin locus via CRISPR/Cas9 system. The reporter cell line not only effectively labelled the insulin-producing cells induced from hESC, but also reflected the cytosolic change of Ca level in response to different stimuli.

Inhibition of the Integrated Stress Response Prevents Natural Forgetting and Corrects Accelerated Forgetting Associated with Epilepsy.

The neural mechanisms underlying the natural and maladaptive forgetting of established memory remain largely unknown. Brain disease states might hijack the physiological forgetting mechanisms, resulting in maladaptive forgetting such as accelerated forgetting that contributes to cognitive decline in various neurologic conditions including epilepsy. Based on the key role of the integrated stress response (ISR) in memory storage and maintenance, we determined whether the ISR underpins natural and accelerated forgetting.

Hepatitis B core virus-like particles bearing Pgp3 antigen enhance immune response against genital chlamydial infection in mice.

Chlamydia trachomatis Pgp3 protein-induced immunoprotection is effective but incomplete, which requires the suitable adjuvants to enhance its immune response. Within this context, Hepatitis B core virus-like particles (HBc-VLP) emerge as nanoscale protein particles capable of incorporating either endogenous or exogenous antigens or epitopes. In this study, HBc-Pgp3 chimeric protein was accomplished by integrating the identified dominant epitope of the Pgp3 protein into the major immunodominant region of a truncated HBc-VLP, which was realized in the pET28a (+) vector and expressed via the E.

Declining trends and regional variations of organophosphate ester contamination in indoor dust from mainland China: Insights from a filed study and meta-analysis.

This study investigated the presence of 20 organophosphate esters (OPEs) in indoor dust samples collected from the Chinese cities of Lanzhou, Xining, and Lhasa. The results demonstrate the ubiquitous presence of most OPEs in these three cities, with the highest concentrations of ΣOPEs found in Xining. We also summarized the occurrence of OPEs in indoor environments from 38 studies with 1875 samples collected across various regions of mainland China from 2012 to 2023.

MC-LR induced apoptosis in human embryonic kidney (HEK293) cells through activation of TNF-R1/RIPK1 pathway.

In recent years, the outbreak of cyanobacterial blooms has become increasingly frequent. Microcystin-LR (MC-LR), a metabolite of cyanobacteria, poses a significant threat to the ecosystem and human health. Several studies have demonstrated that MC-LR might induce renal cell apoptosis, as a consequence of tissue damage.

Cage-Based Metal-Organic Framework Featuring a Double-Yolk Core-Shell UL@UL Structure for Iodine Capture.

Cage-based MOFs, with their customizable chemical environments and precisely controllable nanospaces, show great potential for the selective adsorption of guest molecules with specific structures. In this work, we have constructed a novel cage-based MOF [(CH)NH][(UO)(TMTTA)]·11.5DMF·2HO (IHEP-51), utilizing a triazine derivative poly(carboxylic acid), 4,4',4″-(((1,3,5-triazine-2,4,6-triyl)tris(((4-carboxycyclohexyl)methyl)azanediyl))tris(methylene))tribenzoic acid (HTMTTA), as an organic ligand and uranyl as a metal node.

Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study.

Introduction: Serum folate and vitamin B levels correlate with the prevalence of fatty liver disease, but it is not clear how they affect mortality. Therefore, this study aimed to investigate the association of serum folate and vitamin B concentrations with all-cause mortality in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: MASLD subjects were from the Third National Health and Nutrition Examination Survey (NHANES III) in the United States, and mortality follow-up data were obtained by linkage to death records from the National Death Index.

Visible-Light-Mediated Radical -Hydroboration of Alkynes with NHC Borane.

Although the radical hydroboration of alkenes with N-heterocyclic carbene (NHC) borane is well documented, the radical hydroboration of alkynes, especially terminal alkynes, remains challenging. Herein, a photoredox-catalyzed radical -hydroboration of alkynes with NHC borane has been developed, which provided various alkenyl boron compounds in moderate to good yields. This protocol exhibits a broad substrate scope, as both internal and terminal alkynes were compatible.

Indole-3-Carboxaldehyde Inhibits Inflammatory Response and Lipid Accumulation in Macrophages Through the miR-1271-5p/HDAC9 Pathway.

Indole-3-carboxaldehyde (ICA), a microbiota-derived tryptophan metabolite, has been reported to protect against atherosclerosis. However, the molecular mechanisms for its atheroprotective effect remain largely unknown. This study aimed to explore the influence of ICA on lipid accumulation and inflammatory response in THP-1 macrophage-derived foam cells.

Radiation-induced aberrant structural covariance networks in patients with nasopharyngeal carcinoma: a source-based morphometry study.

Background: Radiation-induced brain injury (RBI) is a common complication in patients with nasopharyngeal carcinoma (NPC) who have undergone radiotherapy (RT), which is characterized by significant cognitive and psychological impairments. Although radiation-induced regional structural abnormalities have been well-reported, the effects of RT on the whole brain structural covariance networks are mostly unknown. Here, we performed a source-based morphometry (SBM) study to solve this issue.

Nomogram for Predicting in-Hospital Severe Complications in Patients with Acute Myocardial Infarction Admitted in Emergency Department.

Background: There is lack of predictive models for the risk of severe complications during hospitalization in patients with acute myocardial infarction (AMI). In this study, we aimed to create a nomogram to forecast the likelihood of in-hospital severe complications in AMI.

Methods: From August 2020 to January 2023, 1024 patients with AMI including the modeling group (n=717) and the validation group (n=307) admitted in Changsha Central Hospital's emergency department.

Alkali burn injury model of meibomian gland dysfunction in mice.

Aim: To establish a stable, short-time, low-cost and reliable murine model of meibomian gland dysfunction (MGD).

Methods: A filter paper sheet soaked in 1.0 mol/L sodium hydroxide (NaOH) solution was used to touch the eyelid margin of C57BL/6J mice for 10s to establish the model.

Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.

Background: The adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke.

Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer.

Background: Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).

Methods: We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods.

Small-Molecule Hole Transport Materials for >26% Efficient Inverted Perovskite Solar Cells.

Chemically modifiable small-molecule hole transport materials (HTMs) hold promise for achieving efficient and scalable perovskite solar cells (PSCs). Compared to emerging self-assembled monolayers, small-molecule HTMs are more reliable in terms of large-area deposition and long-term operational stability. However, current small-molecule HTMs in inverted PSCs lack efficient molecular designs that balance both the charge transport capability and interface compatibility, resulting in a long-standing stagnation of power conversion efficiency (PCE) below 24.

Late-Stage Tailoring Steps in the Biosynthesis of β-Rubromycin Involve Successive Terminal Oxidations, a Selective Hydroxyl Reduction, and Distinctive O-Methylations.

β-Rubromycin () has a unique O-methylated naphthoquinone moiety and is an efficient inhibitor of human telomerase. Through and investigations, we elucidated the biosynthetic tailoring steps of compound , which involve the carboxyl terminal via successive oxidizations by RubU and RubO1/RubO2, O-methylation of the carboxyl terminal by RubX, and reduction of C-3' hydroxyl by RubK. The final tautomerization of the naphthoquinone moiety is mediated by RubO, which anchors the transitional intermediate through O-methylation to form the naphthoquinone tautomer.

A Near-Infrared II Luminogen with a Photothermal Effect toward Tumor Drug Resistance Reversal.

Multidrug resistance of tumor cells has greatly limited the chemotherapy effect. The development of reliable strategies to deal with tumor multidrug resistance is highly desirable for tumor therapy. In this work, a near-infrared II (NIR II) luminogen was rationally designed and prepared, which could act as a photothermal reagent to reverse the drug resistance of tumor cells by reducing the related protein expression, achieving a high inhibition efficiency with the synergistic effect of chemotherapeutic drugs.

Dynamic Mechanical Properties and Damage Morphology Analysis of Concrete with Different Aggregates Based on FDM-DEM Coupling.

To study the dynamic compressive mechanical properties of concrete with different aggregates (limonite and lead-zinc ore), a dynamic mechanical experiment was carried out by the Φ 100 mm SHPB equipment. Based on the coupling of the finite difference method (FDM) and the discrete element method (DEM), a three-dimensional numerical model was constructed. The effects of various strain rates and aggregate types on the dynamic mechanical properties of concrete, the dynamic increase factor (DIF), and the dynamic impact damage process were analyzed and discussed.

Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities.

Hepatocellular carcinoma (HCC), characterized by significant morbidity and mortality rates, poses a substantial threat to human health. The expression of ligands and receptors within the classical and non-classical Wnt signaling pathways plays an important role in HCC. The Wnt signaling pathway is essential for regulating multiple biological processes in HCC, including proliferation, invasion, migration, tumor microenvironment modulation, epithelial-mesenchymal transition (EMT), stem cell characteristics, and autophagy.

Bio-functional niobium-based metallic biomaterials: Exploring their physicomechanical properties, biological significance, and implant applications.

The significance of biomedical applications of bio-functional niobium (Nb)-based metallic biomaterials is underscored by their potential utilization in implant application. Nb-based metallic materials present reliable physicomechanical and biological properties, thus represent materials highly suitable for implant application. This review provides an overview on the advances of pure niobium and Nb-based metallic materials as implant materials over the past 20 years, and highlights the advantages of Nb-based metallic biomaterials for implant application in terms of their physicomechanical properties, corrosion resistance in biological media, magnetic resonance imaging (MRI) compatibility, cell compatibility, blood compatibility, osteogenesis, and bioactivity.