Longitudinal Cross-Lagged Analysis Between Depressive Symptoms, Social Withdrawal, Self-Esteem, and School Adaptation in Multicultural Adolescents.

In Korea, as the number of multicultural families formed through the marriage of Korean men and foreign women from lower-income countries such as China, Southeast Asia, and Central Asia increases, the psychosocial adaptation of adolescents from these families is becoming increasingly important. This study examines the longitudinal and reciprocal relationships among depressive symptoms, social withdrawal, self-esteem, and school adaptation in multicultural adolescents in high schools. We applied an autoregressive cross-lagged model to a sample of 594 multicultural adolescents extracted from three consecutive years of data from the Multicultural Adolescents Panel Survey and found that depressive symptoms and school adaptation had reciprocal negative relationships in multicultural adolescents' first and second years of high school.

{110} Surface-Exposed BiNdTiO Ferroelectric Nanosheet Arrays on Porous Ceramics as Efficient and Recyclable Piezo-Photocatalysts.

Bismuth-layered ferroelectric nanomaterials exhibit great potential for piezo-photocatalysis. However, a major challenge lies in the difficulty of recovering the catalytic powders, raising concerns regarding secondary pollution of water. In this work, a novel hierarchical porous ferroelectric ceramic containing {110} surface-exposed BiNdTiO (BIT-Nd) nanosheet arrays is grown on a porous ceramic matrix for efficient and recyclable piezo-photocatalysis.

Dietary and nutritional interventions for human diseases: their modulatory effects on ferroptosis.

A balanced diet is essential for maintaining human health. Increasing evidence suggests that dietary and nutritional interventions contribute to disease management and are associated with reduced healthcare costs and economic burden. Ferroptosis, a novel type of regulated cell death (RCD) driven by lipid peroxidation, has been shown to be involved in various pathological conditions, including diabetes, ischemia/reperfusion (I/R) injury, inflammation-related diseases, and cancer.

Construction of organic heterojunctions as metal-free photocatalysts for enhancing water splitting and phenol degradation by regulating charge flow.

Metal-free photocatalysts derived from earth-abundant elements have drawn significant attention owing to their ample supply for potential large-scale applications. However, it is still challenging to achieve highly efficient photocatalytic performance owing to their sluggish charge separation and lack of active catalytic sites. Herein, we designed and constructed a series of covalently bonded organic semiconductors to enhance water splitting and phenol degradation.

Dimensional Regulation of Organic n-Type Dopants for Highly Efficient Perovskite Solar Cells and Modules.

A strong n-type perovskite layer is crucial in achieving high open-circuit voltage (V) and power conversion efficiency (PCE) in the p-i-n solar cells, as the weak n-type perovskites result in a loss of V, and the p-type perovskites contain numerous electron traps that cause the severe carrier recombination. Here, three types of perylene diimide (PDI) based small molecule dopants with different dimensions, including 1D-PDI, 2D-PDI, and 3D-PDI are designed, to produce heavier n-type perovskites. The PDI-based molecules with Selenium atoms have a strong electron-donating ability, effectively enlarging the quasi-Fermi level splitting within the perovskites.

Deciphering cell states and the cellular ecosystem to improve risk stratification in acute myeloid leukemia.

Acute myeloid leukemia (AML) demonstrates significant cellular heterogeneity in both leukemic and immune cells, providing valuable insights into clinical outcomes. Here, we constructed an AML single-cell transcriptome atlas and proposed sciNMF workflow to systematically dissect underlying cellular heterogeneity. Notably, sciNMF identified 26 leukemic and immune cell states that linked to clinical variables, mutations, and prognosis.

Plant growth strategies and microbial contributions to ecosystem nitrogen retention along a soil acidification gradient.

Nitrogen (N) retention is a critical ecosystem function associated with sustainable N supply. Lack of experimental evidence limits our understanding of how grassland N retention can vary with soil acidification. A N-labeling experiment was conducted for 2 years to quantify N retention by soil pathways and plant functional groups across a soil-acidification gradient in a meadow.

Enhanced Efficiency and Stability of Tin Halide Perovskite Solar Cells Through MOF Integration.

Tin halide perovskites are promising candidates for lead-free perovskite solar cells due to their ideal bandgap and high charge-carrier mobility. However, poor crystal quality and rapid degradation in ambient conditions severely limit their stability and practical applications. This study demonstrates that incorporating UiO-66, a zirconium-based MOF, significantly enhances the performance and stability of tin halide perovskite solar cells (TPSCs).

The Predictive Value of a Nomogram Based on Ultrasound Radiomics, Clinical Factors, and Enhanced Ultrasound Features for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.

This study aims to establish and validate an ultrasound radiomics nomogram for preoperative prediction of central lymph node metastasis in papillary thyroid microcarcinoma (PTMC) before operation. A retrospective analysis conducted on ultrasonic images and clinical features derived from 288 PTMC patients, who were divided into training cohorts ( = 201) and validating cohorts ( = 87) in a ratio of 7:3 base on the principle of random allocation. Radiomics features were extracted from the PTMC patients after ultrasonic examination, followed by dimension reduction and characteristic selection to construct the radiomics score (Radscore) using LASSO regression analysis.

Cycloolefin Copolymers With a Multiply Rigid Structure for Protecting Triplet Exciton From Thermo- and Moisture-Quenching.

Polymeric room temperature phosphorescence (RTP) materials have been well developed and utilized in various fields. However, their fast thermo- and moisture-quenching behavior highly limit their applications in certain harsh environments. Therefore, the preparation of materials with thermo- and moisture-resistant phosphorescence is greatly attractive.

Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts.

Vascular calcification is a highly regulated process in cardiovascular disease (CVD) and is strongly correlated with morbidity and mortality, especially in the adverse stage of vascular remodeling after coronary artery bypass graft surgery (CABG). However, the pathogenesis of vascular graft calcification, particularly the role of endothelial-smooth muscle cell interaction, is still unclear. To test how ECs interact with SMCs in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression.

Nonfullerene acceptors with carbon-oxygen-bridged fused nonacyclic donor units enable efficient organic solar cells.

The power conversion efficiency (PCE) of an organic solar cell (OSC) mainly depends on the chemical structures and intrinsic properties of its active layer materials. The development of new nonfullerene acceptors (NFAs) has significantly boosted the PCEs of OSCs over the last decade. Herein, two carbon-oxygen-bridged fused nonacyclic donor units were developed to synthesize two NFAs, namely TTPIC-Ar and iTTPIC-Ar, respectively.

The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma.

Objective: The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. Neutrophil extracellular traps (NETs) play a critical role in the pathogenesis of severe asthma.

Development and validation of a nomogram for delirium in the old ischaemic stroke patients.

Aim: To investigate the predictors of post-stroke delirium (PSD) in the old ischaemic stroke patients, and develop a nomogram to predict the risk of PSD.

Methods: A cross-observational study was conducted. The old ischaemic stroke patients in a tertiary hospital in South China were recruited and randomly divided into the train group and test group.

Targeting to mitigate amyloid-β pathology in Alzheimer's disease.

SPI1, a transcription factor implicated in myeloid cell development, has emerged as a genetic risk factor for Alzheimer's disease (AD). Recent in vivo studies reveal that knockdown in mice exacerbates AD pathology by increasing amyloid-β aggregation and gliosis while overexpression ameliorates these features. Transcriptomic analyses suggest that regulates microglial immune response, complement activation, and phagocytosis.

Persistent Penumbral Profiles Indicate a Potentially Good Outcome in Acute Stroke Patients Without Major Reperfusion.

Background: It is acknowledged that penumbra can exist beyond 24 hours after stroke onset.

Aims: The aim of this study was to explore the association between penumbral persistence at 24-72 hours and clinical outcomes in patients who did not achieve major reperfusion.

Methods: Eligible patients participating in the International Stroke Perfusion Imaging Registry with repeated 24-72 hours perfusion imaging were retrospectively included in this study.

Mitigating cadmium contamination in soil using Biochar, sulfur-modified Biochar, and other organic amendments.

Biochar is a novel approach to remediating heavy metal-contaminated soil. Using various organic amendments like phyllosilicate-minerals (PSM), compost, biochar (BC) and sulfur-modified biochar (SMB), demonstrates superior adsorption capacity and stability compared to unmodified biochar (BC). The adsorption mechanisms of SMB are identified for its potential to increase soil-pH and reduce available cadmium (Cd).

Neutrophil extracellular traps promote growth of lung adenocarcinoma by mediating the stability of m6A-mediated SLC2A3 mRNA-induced ferroptosis resistance and CD8(+) T cell inhibition.

To investigate the potential mechanisms underlying neutrophil extracellular traps (NETs) confer ferroptosis resistance and CD8(+) T cell inhibition in lung adenocarcinoma (LUAD). By the intravenous injection of LLC cells into the tail vein, a LUAD mouse model was created. Phorbol-12-myristate-13-acetate (PMA) stimulated neutrophils to facilitate NETs formation and combined with NETs inhibitor DNase I to explore NETs mechanism on LLC cell proliferation, migration, ferroptosis resistance, and CD8(+) T cell activity.

Spectral narrowing strategies in multiple resonance thermally activated delayed fluorescence materials.

Multi-resonance thermally activated delayed fluorescence (MR-TADF) materials possess unique advantages of high-efficiency and narrowband emission, which have rapidly occupied an important position in the field of organic light-emitting diodes (OLEDs). In recent years, significant advancements have been made in the development of MR-TADF materials, particularly in achieving spectral narrowing for high-color-purity OLED applications. Based on diverse MR-TADF molecular skeletons, this review summarizes the primary molecular strategies to narrow spectrum by suppressing structural relaxation and intermolecular interactions.

The Interaction Between Vasculogenic Mimicry and the Immune System: Mechanistic Insights and Dual Exploration in Cancer Therapy.

Vasculogenic mimicry (VM) represents a novel form of angiogenesis discovered in numerous malignant tumours in recent years. Unlike traditional angiogenesis, VM facilitates tumour blood supply independently of endothelial cells by enabling tumour cells to form functional vascular networks. This phenomenon, where tumour cells replace endothelial cells to form tubular structures, plays a pivotal role in tumour growth and metastasis.

An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.

Lipid-lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high-density lipoprotein cholesterol (ieu-b-109), low-density lipoprotein cholesterol (ieu-a-300), triglyceride (ieu-b-111), and total cholesterol (ebi-a-GCST90038690) as exposures.

Persistent effect of salt reduction in schoolchildren and their families: 1-year follow-up after an application-based cluster randomized controlled trial.

Background: A 12-month cluster randomized controlled trial (RCT) demonstrated the effectiveness of an application-based education program in reducing the salt intake and systolic blood pressure (SBP) of schoolchildren's adult family members. This study aimed to assess whether the effect at 12 months persisted at 24 months.

Methods: Fifty-four schools were randomly assigned to either the intervention or control group.

Neutrophil-to-lymphocyte ratio as a prognostic factor in patients with castration-resistant prostate cancer treated with docetaxel-based chemotherapy: a meta-analysis.

Background: In recent years, many studies have illustrated that the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor of metastatic castration-resistant prostate cancer (mCRPC), but their conclusions are controversial. The aim of this study was to assess the prognostic value of the NLR in patients with mCRPC treated with docetaxel-based chemotherapy.

Methods: Database searches were conducted in PubMed, EMBASE and the Cochrane Library to retrieve relevant published English-language literature up to 20 February 2023.

MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway.

Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder attributed to genetic and environmental factors. Microcystin-leucine-arginine (MC-LR) is an environmental toxin that accumulates in the gut and produces intestinal damage. The aim of this study was to investigate the effects of exposure to MC-LR on development and progression of IBD as well examine the underlying mechanisms of microcystin-initiated tissue damage.