Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice.

Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol in the liver, ethanol consumption can be a factor to impair niacin nutritional status. We have recently established the niacin insufficient model mice using kynurenine 3-monooxygenase knock out (KMO) mice with niacin-limited diet, which lack the de novo NAD synthesis pathway from tryptophan.

Measurement of luteinizing hormone surge in vaginal discharge: a potential biomarker that enables simple, non-invasive prediction of the periovulatory period.

Background: Predicting the periovulatory period is very important for conception. Current approaches to predicting the periovulatory period include monitoring of basal body temperature and urine luteinizing hormone (LH) concentration; however, these methods are time-consuming. Here, we examined the potential of using vaginal discharge (VD) as a non-invasive means of sample collection for determining the LH surge that indicates ovulation.

Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study.

Objective: To investigate the relationship between oral frailty (OF), nutrient intake and calf circumference (CC) in middle-aged and older adults.

Design: Cross-sectional study.

Setting: Residents of four model districts of Shika town, Ishikawa Prefecture, Japan, using data from November 2017 to February 2018.

Addressing the taxonomic confusion of Mesocoelium Odhner, 1910 (Trematoda: Plagiorchioidea: Mesocoeliidae) in Japanese urodelan and anuran amphibians.

Trematodes of the genus Mesocoelium Odhner, 1910 (Digenea: Plagiorchioidea: Mesocoeliidae) are globally distributed and parasitize amphibians, reptiles, or occasionally fishes. This genus is one of the most confusing taxa in trematodes because of its poor morphological features. In this study, we examined species of Mesocoelium collected from Japanese amphibians and found that they can be morphologically assigned to two species of Mesocoelium.

Reproductive interference between alien species in Veronica.

Reproductive interference can lead to the exclusive distribution of species. Reports on reproductive interference between alien species are scarce, although alien species are becoming more abundant and evaluations of the interference between aliens and its influence on community structure are essential. We therefore investigated the presence of interference in two alien species of Veronica, V.

Life-cycle analysis of environmental loads from household septic systems in Japan focusing on effluent water discharge.

Various types of small-scale wastewater treatment systems are widely used in rural areas, and life-cycle assessment (LCA) should be performed to evaluate their environmental performance. In this study, septic systems were first classified into five categories based on their wastewater treatment performance. Effluent samples from actual systems were collected, and their water qualities were determined.

Nanobubbles in vase water inhibit transpiration and prolong the vase life of cut chrysanthemum flowers.

Nanobubble (NB) water has been shown to promote the growth of several types of plants and animals, but the mechanism underlying this promoting effect remains unclear. The present study evaluated the mechanism by which NBs maintain the freshness of cut flowers by keeping cut chrysanthemum ( Ramat.) flowers at the bud stage in vase water containing air NBs.

Effect of seaweed feeding before calving on colostral IgA concentration in Japanese Black cows.

In this study, we investigated the effect of feeding seaweed to Japanese Black cows before calving on IgA concentrations in colostrum. Seven Japanese Black breeding cows were used as test animals, with three cows in the seaweed-fed group (seaweed group) and four in the seaweed-non-fed group (control group). Each cow was fed 6 kg of sudangrass hay and 2.

Isomerism tunes the diradical character of difluorenopyrroles at constant Hückel-level anti-aromaticity.

A new diradical based on diindenocarbazole or difluorenopyrrole was synthesized and experimentally characterized by optical, electrochemical, and magnetic techniques, as well as quantum chemical calculations. The isomerism of these structures tunes the diradical character and the associated properties, representing a unique case of such important modulation. A full study of the electronic structure was carried out considering the perturbative interactions between different canonical forms as well as the anti-aromatic character of the molecular cores.

Phylogenetic, population structure, and population demographic analyses reveal that Vicia sepium in Japan is native and not introduced.

Vicia sepium (bush vetch) is a perennial legume widely distributed throughout the Eurasian continent. However, its distribution in Japan is limited to Mt. Ibuki and small parts of central and southern Hokkaido.

Intragastric administration of cinnamaldehyde induces changes in body temperature via TRPA1.

The transient receptor potential (TRP) channel family, including TRPA1, is known to be involved in temperature sensing and response. Previous studies have shown that intragastric administration of cinnamaldehyde (a typical TRPA1 agonist) can change body temperature, but the role of TRPA1 in this response is not clear. In this study, we found that intragastric administration of cinnamaldehyde increased in the intrascapular brown adipose tissue (IBAT) and rectal temperatures.

Kinetically Controlled Direct Synthesis of B2- and A1-Structured Cu-Pd Nanoparticles.

Atomic arrangement in Cu-Pd alloy nanoparticles (NPs) has been reported to influence the catalytic activity, but they have yet to be studied in detail. Unlike previous studies, where the B2 structure Cu-Pd NPs are obtained by heat treating the A1 structure, this study reports the one-pot direct syntheses of A1- and B2-structured Cu-Pd NPs using an alcohol reduction method. The alcohol reduction technique facilitates the kinetic control of the reduction reaction by selecting the appropriate alcohol type and complexing agent to delay the reduction of easily reducible metallic elements to realize control over the reduction kinetics for coreduction.

Establishment of Model Mice to Evaluate Low Niacin Nutritional Status.

Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity, and low NAD levels with aging and feeding high fat diets develop and progress age-related diseases. Although recent findings suggest the requirement of niacin insufficient animal model to further study, appropriate animal models have not been established yet because niacin is biosynthesized from tryptophan via tryptophan-nicotinamide pathway. To establish model mice to evaluate niacin nutritional status, we used kynurenine 3-monooxygenase knock out (KMO) mice which lack NAD biosynthesis pathway from tryptophan.

Fabrication and photoelectric conversion of densely packed C-ethylenediamine adduct microparticle films-modified electrode covered with electrochemically deposited polythiophene thin-films.

Polythiophene-modified densely packed C-ethylenediamine adduct microparticle films were prepared using a combination of liquid-liquid interfacial precipitation of the adduct microparticles and electrochemical polymerization of 2,2'-bithiophene. The amount of polythiophene was varied as a function of scanning cycles of the applied potential during electrochemical polymerization. Fluorescence-emission properties of these composite films suggested the role of C-ethylenediamine adduct microparticle film as a photosensitizer in addition to an electron acceptor for polythiophene.

Inhibition of the mitochondrial respiratory chain reduces catecholamine‑stimulated lipolysis via increasing lactate production in 3T3‑L1 adipocytes.

Adipose tissue serves a significant role in the regulation of energy metabolism in the body. The re‑esterification of the fatty acids generated during lipolysis is critical for efficient lipolysis. However, the effect of the intracellular energy state on lipolytic activity and fatty acid re‑esterification during lipolysis is not yet fully understood.

Suffering of patients developing lymphedema following gynecological cancer surgery.

Objective: Lymphedema developing in the lower extremities following gynecological cancer surgery (LE-GCS) produces various kinds of sufferings, including impacts on quality of life (QOL) and body image. This research will serve as a basic resource for the care of patients with this type of lymphedema (LE).

Patients And Methods: A qualitative discursive research method: Thirteen patients suffering from LE-GCS were interviewed in a semi-organized manner.

Association between internet addiction, brain structure, and social capital in adolescents.

Of late, internet addiction among adolescents has become a serious problem, with increased internet use. Previous research suggests that the more people become addicted to the internet, the more they isolate themselves from society. Conversely, it has been suggested that abundant social capital (the networks of relationships among people who live and work in a particular society) protects people from becoming addicted to the internet.

Hope and its associated factors in cancer patients undergoing drug therapy: a systematic review.

Objective: This study seeks to clarify the hope of cancer patients undergoing drug therapy and related factors through a systematic review.

Methods: References were searched and selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses.

Results: Thirteen articles were selected.

Molecular phylogenetic position and the life cycle of Phyllodistomum cyprini Feng et Wang, 1995 in Japan, with a note of a larval Phyllodistomum sp. from unionid mussels in North America.

A gorgoderid species, Phyllodistomum cyprini Feng et Wang, 1995 obtained from ureters of common carp, Cyprinus carpio in Japan is described both morphologically and molecularly. Its larval stage is a macrocercous cercaria found in a unionid mussel, Nodularia nipponensis first described by Urabe et al. (2015).

Horizontally Transferred DNA in the Genome of the Fungus Pyricularia oryzae is Associated With Repressive Histone Modifications.

Horizontal gene transfer (HGT) is a means of exchanging genetic material asexually. The process by which horizontally transferred genes are domesticated by the host genome is of great interest but is not well understood. In this study, we determined the telomere-to-telomere genome sequence of the wheat-infecting Pyricularia oryzae strain Br48.

Distinct associations between dietary omega-3 and omega-6 fatty acids intake with chronic kidney disease in adults with and without diabetes: A cross-sectional study.

Objective: We explored the relationship of dietary intake of fatty acids with chronic kidney disease (CKD) according to glycemic status in Japanese people.

Methods: A total of 1031 participants aged ≥40 y were included in this population-based, cross-sectional study. A validated self-administered diet history questionnaire was used to measure the dietary intakes of fat and fatty acids, including omega-3 and omega-6 polyunsaturated fatty acids.

Simultaneous detection of force and tunneling current in electrolyte solution by using qPlus sensor.

We have developed a sensor for simultaneous measurement of atomic force microscopy (AFM) and scanning tunneling microscopy (STM) under liquid environments. The sensor, which is based on the qPlus sensor, is equipped with an insulated conductive tip. Owing to its electrical insulation except for the tip apex, the developed sensor enabled simultaneous detection of tip-sample interaction force and tunneling current, suppressing the Faradaic leakage current.

Feeding of mussel-associated leeches Hemiclepsis kasmiana on bitterling embryos: Novel interaction between parasites in a shared host.

We investigated an interaction between bitterlings and a parasitic leech Hemiclepsis kasmiana in freshwater mussel hosts. We found that leeches fed on bitterling eggs and embryos; this may exert a considerable negative effect on bitterling fitness. Host choices by females of three bitterling species may be differently affected by the presence of leeches within mussels; Tanakia limbata apparently avoided laying eggs in infested mussels while T.

Intermittent fasting reduces mouse body fat while maintaining muscle mass by regulating protein synthesis and autophagy.

Objectives: The aim of this study is to investigate the effect of intermittent fasting (IF) on the regulation of skeletal muscle protein metabolism in response to nutrient supplementation during fasting.

Methods: Twelve-week-old male C57BL/6J mice were assigned to two groups: ad libitum and IF, with the latter having access to food for only 3 h/d. After 6 wk of experimental periods, an oral glucose tolerance test was performed.