Selectively inhibiting malignant melanoma migration and invasion in an engineered skin model using actin-targeting dinuclear Ru-complexes.

Due to the poor prognosis of metastatic cancers, there is a clinical need for agents with anti-metastatic activity. Here we report on the anti-metastatic effect of a previously reported Ru(ii) complex [{(phen)Ru}(tpphz)], 1, that has recently been shown to disrupt actin fiber assembly. In this study, we investigated the anti-migratory effect of 1 and a close structural analogue, 2, on two highly invasive, metastatic human melanoma cell lines.

Triazole-based osmium(ii) complexes displaying red/near-IR luminescence: antimicrobial activity and super-resolution imaging.

Cellular uptake, luminescence imaging and antimicrobial activity against clinically relevant methicillin-resistant (MRSA) bacteria are reported. The osmium(ii) complexes [Os(^)] (^ = 1-benzyl-4-(pyrid-2-yl)-1,2,3-triazole ( ); 1-benzyl-4-(pyrimidin-2-yl)-1,2,3-triazole ( ); 1-benzyl-4-(pyrazin-2-yl)-1,2,3-triazole ( )) were prepared and isolated as the chloride salts of their meridional and facial isomers. The complexes display prominent spin-forbidden ground state to triplet metal-to-ligand charge transfer (MLCT) state absorption bands enabling excitation as low as 600 nm for /- and observation of emission in aqueous solution in the deep-red/near-IR regions of the spectrum.

Mononuclear ruthenium(ii) theranostic complexes that function as broad-spectrum antimicrobials in therapeutically resistant pathogens through interaction with DNA.

Six luminescent, mononuclear ruthenium(ii) complexes based on the tetrapyridophenazine (tpphz) and dipyridophenazine (dppz) ligands are reported. The therapeutic activities of the complexes against Gram-negative bacteria (, , ) and Gram-positive bacteria ( and ) including pathogenic multi- and pan-drug resistant strains were assessed. Estimated minimum inhibitory and bactericidal concentrations show the activity of the lead compound is comparable to ampicillin and oxacillin in therapeutically sensitive strains and this activity was retained in resistant strains.

Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA.

[This corrects the article DOI: 10.1039/C8SC05084H.].