Exploring the impact and challenges of tele-ICU: A qualitative study on nursing perspectives.

Aim: The primary objectives of this study were to explore ICU and Tele-ICU nurses' perceptions of Tele-ICU, focusing on its perceived benefits, challenges, and implications for integration into critical care settings.

Background: Tele-Intensive Care Unit (Tele-ICU) services are reshaping critical care by enabling remote monitoring and enhancing patient outcomes. This study investigates the experiences of nurses transitioning from bedside ICU to Tele-ICU roles, focusing on the impact on patient care, organizational benefits, and implementation challenges.

Association Between Perceived Control and Acute Coronary Syndrome Symptom Severity: A Prospective Cohort Study.

Aim: To determine whether there are differences in patterns of symptom severity in three major ACS symptoms (i.e., chest pain, fatigue, and dyspnoea) over the days of CCU stay between patients with higher and lower levels of perceived control.

Predictive and Prognostic Significance of Patient-Reported Outcomes for Survival and Adverse Events in Daratumumab-Treated Multiple Myeloma.

Objectives: Patient-reported outcomes (PROs), including physical function, have predictive potential for survival but remain underexplored in multiple myeloma (MM). This study evaluates the predictive and prognostic value of PROs for treatment outcomes in MM patients on daratumumab-based therapy and evaluates physical function versus ECOG Performance Status as a potential treatment-effect modifier.

Methods: Data was pooled from randomized trials (MAIA, POLLUX, CASTOR) that collected pretreatment PROs using EORTC QLQ-C30.

Unraveling Hematological Anomalies in DiGeorge Syndrome: A Retrospective Study of Thrombocytopenia and Mean Platelet Volume.

Background: DiGeorge syndrome, arising from chromosome 22q11.2 deletion including the gene, is known for its multifaceted developmental anomalies affecting the heart, immune system, and facial morphology. Despite extensive clinical characterization, hematological manifestations, particularly thrombocytopenia, remain underexplored.

Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model.

Objective: Severe steroid hyporesponsive asthma is a heterogeneous group of chronic inflammatory diseases characterized by irreversible airflow limitation, hyperresponsiveness, inflammation, and remodelling of the airways. Severe asthmatics account for more than 60% of asthma-related healthcare cost worldwide given they are hyporesponsive to corticosteroids and due to the absence of targeted treatment specifically for the T helper-17 (Th-17) high endotype. Hence, there is a clear unmet need to investigate other treatment options to control patients' symptoms.

Cardiometabolic and Obesity Risk Outcomes of Dawn-to-Dusk, Dry Intermittent Fasting: Insights from an Umbrella Review.

Background & Aims: This umbrella review comprehensively and systematically summarizes meta-analyses on the impact of dawn-to-dusk, dry intermittent fasting of Ramadan (RIF) on cardiometabolic and glucose homeostasis indicators.

Methods: Twenty meta-analyses were examined on the effects of RIF on body fat percentage (BFP), fat mass, fat-free mass, body mass index (BMI), body weight (BW), waist circumference (WC), systolic and diastolic blood pressure (SBP, DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and very low-density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), serum insulin, leptin, and adiponectin. Results of continuous outcomes were pooled from included meta-analyses.

Butyrate (short-chain fatty acid) alleviates lipopolysaccharide-binding proteins and improves physical function in knee osteoarthritis patients.

Knee-osteoarthritis (OA) is often associated with increased intestinal permeability, potentially causing sarcopenia, and mobility issues. Current treatments are ineffective. The objective of this study was to investigate if butyrate improves sarcopenia and physical function in knee-OA patients, and if improvements correlate with changes in gut health, specifically intestinal permeability, and bacterial load.

Machine learning prediction of overall survival in prostate adenocarcinoma using ensemble techniques.

Prostate adenocarcinoma (PAC) is a complex and common cancer in males and is one of the leading causes of cancer-related death globally. PAC is a multifaceted disease that encompasses different subtypes, including acinar and ductal adenocarcinoma, small cell carcinoma, neuroendocrine tumors, and transitional cell carcinoma with each subtype presenting distinct prognostic difficulties. Therefore, predicting the overall survival (OS) rate of individuals with PAC continues to be a substantial clinical barrier due to the diverse nature of the illness, coexisting medical conditions, and constraints associated with conventional diagnostic markers.

Climate change and health in the Arctic.

Aim: Adverse human-driven environmental change, including the climate, is having an increasing impact on the Arctic environment and its ecosystems. There has been immense interest in understanding the health risks related to climate change in the Arctic region. In this article, we review recent evidence related to climate change and its impacts on the health of the Arctic population.

The association of particulate matter PM and nitrogen oxides from ambient air pollution and mental health of children and young adults- a systematic review.

Introduction: The developing brain, especially vulnerable during neuroplastic phases, is influenced by environmental and genetic factors. Understanding the impacts of air pollution on children's and young adults' mental health is an emerging research field.

Content: This review systematically examines the adverse associations of ambient air pollutants on mental health.

The Effect of Intermittent Fasting on Salivary Inflammatory Cytokines and Dopamine Levels.

Objectives:  The current study elucidates potential alterations in inflammatory cytokines and dopamine (DA) levels in saliva following a 21-day fasting regimen during Ramadan and explores their associations with mental health parameters.

Materials And Methods:  Forty-four healthy young university students (22 females and 22 males; median age 22 (2) and body mass index 23.40 (6.

Strategies to enhance nurses' adherence to central line-associated bloodstream infection prevention bundles in the ICU setting: A systematic review.

Background: The incidence of central line-associated bloodstream infection (CLABSI) in the ICU continues to rise. Despite existing CLABSI bundles to prevent infections, adherence remains suboptimal.

Objective: To identify and synthesize the evidence about strategies used to enhance nurses' adherence to CLABSI prevention bundles.

Examining shift duration and sociodemographic influences on the well-being of healthcare professionals in the United Arab Emirates: a cross-sectional study.

Objective: Providing quality healthcare is an essential part of the healthcare system. The high workload and night work associated with healthcare providing may result in work-life imbalance among healthcare professionals (HCPs) and in degradation in the quality of care.

Methods: This cross-sectional study aimed to assess the effects of sociodemographic characteristics and shift work on HCPs' well-being in four large hospitals in the United Arab Emirates using a validated questionnaire.

Cobalt-nickel composite nano-grass as an excellent electrode for urea oxidation.

Urea-contaminated wastewater requires extensive energy for proper treatment before safe discharge to the surroundings. Direct urea fuel cells (DUFCs) could be utilized efficiently to treat urea-polluted water and generate electricity. The precious/expensive catalyst utilized at the electrodes is one of the main significant challenges to DUFC commercialization.

Detection of concha bullosa using deep learning models in cone-beam computed tomography images: a feasibility study.

Background: Pneumatization of turbinates, also known as concha bullosa (CB), is associated with nasal septal deviation and sinonasal pathologies. This study aims to evaluate the performance of deep learning models in detecting CB in coronal cone-beam computed tomography (CBCT) images.

Methods: Standardized coronal images were obtained from 203 CBCT scans (83 with CB and 119 without CB) from the radiology archives of a dental teaching hospital.

Evaluation of salivary Ki-67 in health and periodontitis.

Background: Ki-67, a nuclear protein is found in cells undergoing proliferation during the cell cycle. It has been established as an important tumor proliferation and prognostic marker. An increased expression of Ki-67 is observed in inflammation.

Accuracy of deep learning models in the detection of accessory ostium in coronal cone beam computed tomographic images.

Accessory ostium [AO] is one of the important anatomical variations in the maxillary sinus. AO is often associated with sinus pathology. Radiographic imaging plays a very important role in the detection of AO.

Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.

Background: Despite the close association of Alzheimer's disease (AD) with muscle decline, the biomarkers of age-related muscle loss, termed sarcopenia, in AD remain elusive.

Objectives: We investigated the plasma neurofilament light (NfL) chain levels as potential biomarkers of sarcopenia in AD patients. DESIGN SETTING, PARTICIPANTS, MEASUREMENTS: We conducted a cross-sectional, observational study on older adults, including controls and patients with AD (n = 38-44/group).

Bacterial synthesis of anisotropic gold nanoparticles.

Pseudomonas aeruginosa was used to synthesize anisotropic gold nanoparticles from the unusually reducible aryldiazonium gold (III) salt of the chemical formula [HOOC-4-CHN≡N]AuCl (abbreviated as DS-AuCl). We investigated the effect of bacterial cell density, temperature, and pH on the AuNP synthesis. The bacterial cell density of 6.

Non-Hodgkin Lymphoma Manifesting as Bilateral Tonsillar Hypertrophy: A Case Report.

Non-Hodgkin lymphoma (NHL) is a diverse group of lymphoid malignancies, with varied clinical presentations depending on the anatomical site of involvement. Although typically presenting with nodal disease, extranodal manifestations are not uncommon. NHL involving Waldeyer's ring is considered rare, with the palatine tonsils being the most frequently affected location.

Patients' Perceptions and Success Rate of Temporary Anchorage Devices After the Immediate and Delayed Loading of Orthodontic Mini-Implants-Randomized Clinical Trial.

Background: The search for an ideal anchorage during orthodontic treatment resulted in the invention of Orthodontic Mini Implants (OMIs) that do not require patient's cooperation. In spite of their common use in orthodontics, there is a lack of studies regarding patients' perceptions of OMIs after their immediate and delayed loading.

Aim: The aim of this study was to compare the pain and discomfort experienced by patients following the placement of orthodontic mini-implants and immediate loading with delayed loading, and to evaluate their success rate to formulate a definite clinical protocol for loading of the orthodontic mini-implants.

Effect of Passive Immunotherapeutics (IgY) on S. Mutans in Caries Active Children 8-11 Years of Age.

Introduction: Dental caries is a multifactorial disease caused by combined effect of host, environment, and microorganism. Mutans Streptococci (MS) is the main microorganism in causing and progression of dental caries. Advances in science and technology led to attempt in managing dental caries by targeting its initiation and delaying its progress.

Flourescent Based Camera (QSCAN Plus) for Dental Plaque Quantification: Validation and Reliability.

Introduction: Detection and quantification of dental plaque is crucial in both clinical dentistry and research. Established clinical indices used to measure dental plaque have limitations. The aim of the study was to evaluate the reliability and validity of plaque quantification using a fluorescent camera (QScan Plus).

Evaluation of Displacement with Rapid Maxillary Expansion, Miniscrew-Assisted Rapid Maxillary Expansion, and Miniscrew-Assisted Rapid Maxillary Expansion Combined with Micro-Osteoperforations: A Comparative Finite Element Analysis.

Background And Objectives: Maxillary expansion is one of the most commonly advocated treatment approaches for the management of the maxillary deficiency in the transverse plane and is possible because of the presence of mid-palatal suture. This finite element method (FEM) study was taken to evaluate the stress pattern and displacement in the screw and its adjacent structures used in three different treatment modalities, such as rapid maxillary expansion (RME), mini-implant-assisted rapid palatal expansion (MARPE), and MARPE in conjunction with micro-osteoperforations.

Materials And Methods: An adult human dried skull, cone-beam computed tomography (CBCT) of the skull, and FEM and associated software (GEOMAGIC) were included.