Effect of Exposure to Blue Light from Electronic Devices and the Mediterranean Diet on Macular Pigment.

To explore the effect of time exposure to flat screen electronic devices with LED lighting and the Mediterranean diet on macular pigment optical density (MPOD). In this cross-sectional observational study, the MPOD was measured by heterochromatic flicker photometry in 164 eyes (47 of younger women aged 20-31 and 35 of older women aged 42-70). Exclusion criteria: evidence of macular degeneration and eyes with cataracts.

Use of Infrared Thermography in Podiatry: Systematic Review and Meta-Analysis.

Infrared thermography is an advanced technique that detects infrared light emitted by the body to map thermal changes related to blood flow. It is recognized for being noninvasive, fast, and reliable and is employed in the diagnosis and prevention of various medical conditions. In podiatry, it is utilized for managing diabetic foot ulcers, musculoskeletal injuries such as Achilles tendinopathy, and onychomycosis, among others.

Predictive Modeling of Heart Rate from Respiratory Signals at Rest in Young Healthy Humans.

Biological signals such as respiration (RSP) and heart rate (HR) are oscillatory and physiologically coupled, maintaining homeostasis through regulatory mechanisms. This report models the dynamic relationship between RSP and HR in 45 healthy volunteers at rest. Cross-correlation between RSP and HR was computed, along with regression analysis to predict HR from RSP and its first-order time derivative in continuous signals.

Ancient DNA Reveals the Earliest Evidence of Sheep Flocks During the Late Fourth and Third Millennia BC in Southern Iberia.

The Spanish Merino is the most significant sheep breed globally due to its economic and cultural importance in human history. It has also had a substantial influence on the development of other Merino and Merino-derived breeds. Historical sources indicate that crossbreeding to produce finer, higher-quality wool was already taking place in the south of the Iberian Peninsula during the Roman era.

Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation.

Filamin A (FLNA) is an actin-binding protein that has been reported to interact with STIM1 modulating the activation of Orai1 channels. Cleaving of FLNA by calpain leads to a C-terminal fragment that is involved in a variety of functional and pathological events, including pro-oncogenic activity in different types of cancer. Here we show that full-length FLNA is downregulated in samples from colon cancer patients as well as in the adenocarcinoma cell line HT-29.

PRAME Immunostaining in BAP-1-Inactivated Melanocytic Tumors: Unraveling Diagnostic Complexity and Exploring Germline Mutation Associations.

Background: Cutaneous melanocytic tumors with BAP-1 inactivation (BIMTs), linked to mutations in the BAP-1 gene, present diagnostic challenges due to their morphological similarities with other melanocytic lesions. The search for reliable diagnostic markers, including PRAME, holds potential to significantly improve the accuracy of differential diagnoses.

Methods: A retrospective analysis of 32 BIMTs from 25 patients, collected between 2018 and 2022, involved histologic examination and immunostaining for BAP-1 and PRAME.

Efficacy of Lurasidone in First-Episode Psychosis: Patient Phenotypes, Dosage, and Recommendations from an Expert Panel.

Introduction: For patients with psychosis, early, intensive therapeutic intervention is thought to improve long-term outcomes. Furthermore, patients with a first-episode psychosis (FEP) who experience a good early response to antipsychotic medication show a clinical and functional benefit over the longer term if they continue low-dose antipsychotic treatment. Lurasidone is an atypical antipsychotic agent which is approved in Europe for the treatment of schizophrenia in adults and adolescents (13-17 years).

Telomere-based risk models for the early diagnosis of lung cancer.

Background: The objective of this study was to evaluate the use of telomere length measurements as diagnostic biomarkers during early screening for lung cancer in high-risk patients.

Methods: This was a prospective study of patients undergoing lung cancer diagnosis at two Spanish hospitals between April 2017 and January 2020. Telomeres from peripheral blood lymphocytes were analysed by Telomere Analysis Technology, which is based in high-throughput quantitative fluorescent in situ hybridization.

The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy.

Introduction: Neural stem cells from the subventricular zone (SVZ) neurogenic niche provide neurons that integrate in the olfactory bulb circuitry. However, in response to cortical injuries, the neurogenic activity of the SVZ is significantly altered, leading to increased number of neuroblasts with a modified migration pattern that leads cells towards the site of injury. Despite the increased neurogenesis and migration, many newly generated neurons fail to survive or functionally integrate into the cortical circuitry.

Amplified impacts of human activities: Non-linear responses of riverine microbial communities to distribution of land use.

Rapid global urbanization poses considerable ecological risks to freshwater systems, notably leading to substantial reductions in microbial communities. To assess the impacts of human activities on these communities, we applied the high-throughput amplicon DNA sequencing to examine spatial variations in riverine microbial communities within an urbanized watershed. Coupled with the Geographical Detector Model, the effects of the land use were identified across the watershed.

Investigation of bacterial nanocellulose/calcium phosphates-based composite containing cerium for bone repair.

Bacterial nanocellulose (BNC) has attracted considerable attention in the field of biomedical engineering due to its potential for use in bone regeneration applications. The present study investigates the in vitro and in vivo efficacy of bacterial nanocellulose (BNC) combined with calcium and cerium ions (BNC-Ce:CaP) in bone regeneration applications. XRD analysis confirmed the presence of monetite and hydroxyapatite phases in BNC-CaP, while BNC-Ce:CaP revealed an additional brushite phase.

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines.

Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.

A European Survey to Identify Challenges in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Background And Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe subtype, metabolic dysfunction-associated steatohepatitis (MASH), are highly prevalent and strongly associated with obesity and type 2 diabetes (T2D). This study sought to identify challenges to the diagnosis, treatment and management of people living with MASLD and MASH and understand the key barriers to adopting relevant clinical guidelines.

Methods: A real-world, cross-sectional study (BARRIERS-MASLD) consisting of a quantitative survey and qualitative interviews of physicians in France, Germany, Italy, Spain and the United Kingdom was conducted from March to September 2023.

The Function of Memes in Political Discourse.

The use of memes has become increasingly widespread in political discourse. However, there is a dearth of philosophical discussion on memes and their impact on political discourse. This paper addresses this gap in the literature and bridges the divide between the empirical and philosophical work on memes by offering a functionalist account which allows for a more in-depth analysis of the role memes play in political discourse.

What about language?

Myths about a remote shared past can certainly promote cooperation between distantly related people, seemingly via their impact on our social cognition, and ultimately facilitate the achievement of complex tasks in large-scale societies. Nonetheless, the creation and transmission of these complex narratives are not possible without the parallel development of sophisticated language(s), endowed with properties like displacement (enabling mental travels in space and time) and complex syntax (enabling the assembly and communication of complex thoughts).

Aspartate signalling drives lung metastasis via alternative translation.

Lung metastases occur in up to 54% of patients with metastatic tumours. Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells. Moreover, secreted factors from primary tumours alter immune cells and the extracellular matrix of the lung, creating a permissive pre-metastatic environment primed for the arriving cancer cells.

PEROXYNITRITE IS INVOLVED IN THE MITOCHONDRIAL DYSFUNCTION INDUCED BY SORAFENIB IN LIVER CANCER CELLS.

Background: Sorafenib is a tyrosine kinase inhibitor (TKI) that belongs to the landscape of treatments for advanced stages of hepatocellular carcinoma (HCC). The induction of cell death and cell cycle arrest by Sorafenib has been associated with mitochondrial dysfunction in liver cancer cells. Our research aim was to decipher underlying oxidative and nitrosative stress induced by Sorafenib leading to mitochondrial dysfunction in liver cancer cells.

Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation: Rationale and Design for PRESTIGE-AF Trial.

Adequate secondary prevention in survivors of intracerebral hemorrhage (ICH) who also have atrial fibrillation (AF) is a long-standing clinical dilemma because these patients are at increased risk of recurrent ICH as well as of ischemic stroke. The efficacy and safety of oral anticoagulation, the standard preventive medication for ischemic stroke patients with AF, in ICH patients with AF are uncertain. PRESTIGE-AF is an international, phase 3b, multi-center, randomized, open, blinded end-point assessment (PROBE) clinical trial that compared the efficacy and safety of direct oral anticoagulants (DOACs) with no DOAC (either no antithrombotic treatment or any antiplatelet drug).

Laparoscopic common bile duct exploration for choledocholithiasis on an emergency setting.

Introduction: Choledocholithiasis is a common clinical condition that may present with severe complications such as acute cholecystitis or cholangitis, requiring treatment on an emergency setting. This situation is frequently managed following an endoscopic approach by ERCP. However, access to emergent endoscopic biliary decompression is lacking in most centers.

Predictive factors for complete pathologic response in luminal breast cancer: impact of ki67 and HER2 low expression.

Background: Complete pathological response to neoadjuvant treatment (NAT) in breast cancer is associated with prolonged survival. Compared to other breast cancer immunophenotypes, luminal tumors are the least chemosensitive with low rates of pathological response within this molecular subtype. Thus, finding predictors of response in this subset remains challenging.

Content validation of the nursing diagnosis "Frail Elderly Syndrome (00257)".

Objective: To increase the level of evidence available for the nursing diagnosis "Frail Elderly Syndrome 000257" through content validation by nurses with expertise in caring for the elderly.

Method: Diagnostic content validation study in accordance with Fehring's proposal composed of two stages: integrative review of the literature according to Whittemore and Knafl's guidelines, which allowed us to update the diagnostic components, and, subsequently, expert consensus study by means of the Delphi method. A total of 61 nurses who met the inclusion criteria were included.

SLAMF7 defines subsets of human effector CD8 T cells.

Long-term control of viral replication relies on the efficient differentiation of memory T cells into effector T cells during secondary immune responses. Recent findings have identified T cell precursors for both memory and exhausted T cells, suggesting the existence of progenitor-like effector T cells. These cells can persist without antigenic challenge but expand and acquire effector functions upon recall immune responses.

Nursing Students' Experiences About Clinical Practice Tutoring: A Cross-Sectional Observational Study.

Unlabelled: Nursing students' experiences about clinical practice tutoring in a public university from southern Spain and at its two attached educational centres were analysed.

Methods: A cross-sectional observational study was carried out. The population was comprised of nursing students attending their fourth year of university during the 2023/2024 academic period, with a final sample of 179 subjects.

Enhancing Nursing Competencies: An Assessment of Knowledge and Attitudes Toward Dental Trauma Management Among Nursing Students-An Interventional Study.

Introduction: Traumatic dental injuries (TDIs) present a significant challenge for healthcare professionals. Nurses, often the first point of contact for patients, may lack essential knowledge in dental trauma first aid, as noted in the existing literature.

Objective: To assess the knowledge of traumatic dental injuries (TDIs) among undergraduate nursing students before and after a targeted educational intervention.