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Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus.

J Pineal Res

September 2008

Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgin Macarena University Hospital, Seville, Spain.

Antonio J Jimenez-Caliani Silvia Jimenez-Jorge Patrocinio Molinero Amalia Rubio Juan M Guerrero

MRL/MpJ-Fas(lpr) mice is widely accepted as a valuable model of systemic lupus erythematosus. As described in a previous work, the incidence of lupus in this strain is determined by sex hormones, i.e.

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Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus.