Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795) polymorphisms among breast cancer patients in western Algeria.

Breast cancer (BC) is the most frequently diagnosed cancer among women worldwide, including Algeria. Certain single nucleotide polymorphisms (SNPs) have been linked to higher risk of BC. Several studies have been performed on the insulin- like growth factor 1 (IGF-1) T > C (rs7136446) and the interleukin 6 (IL-6) 174 G > C (rs1800795) SNPs to explore their role in BC.

In silico analysis for SARS-CoV-2 detection in the context of genetic variability of the Algerian omicron variant.

The risk to public health conferred by the Omicron variant is still not completely clear, although its numerous gene mutations have raised concerns regarding its potential for increased transmissibility and immune escape. In this study, we test the compatibility of the different primers and probes available in different commercial kits sold internationally with all the sequences of SARS-CoV-2 analyzed in Algeria until March 2023. The Algerian SARS-CoV-2 Omicron variant sequences were aligned with the Muscle tool using Genious software.

Enhancing tumor's skin photothermal therapy using Gold nanoparticles : a Monte Carlo simulation.

The aim of this study is to investigate how the introduction of Gold nanoparticles GNPs into a skin tumor affects the ability to absorb laser light during multicolor laser exposure. The Monte Carlo Geant4 technique was used to construct a cubic geometry simulating human skin, and a 5 mm tumor spheroid was implanted at an adjustable depth x. Our findings show that injecting a very low concentration of 0.

Effects of the presentation order of stimulations in sequential ERP/SSVEP Hybrid Brain-Computer Interface.

Hybrid Brain-Computer Interface (hBCI) combines multiple neurophysiology modalities or paradigms to speed up the output of a single command or produce multiple ones simultaneously. Concurrent hBCIs that employ endogenous and exogenous paradigms are limited by the reduced set of possible commands. Conversely, the fusion of different exogenous visual evoked potentials demonstrated impressive performances; however, they suffer from limited portability.

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria.

Functional gastrointestinal (GI) disorders are recognized as a major public health concern worldwide. These disorders involve persistent digestive symptoms indicative of digestive tract dysfunction. A survey examining the utilisation of probiotics and medicinal plants as supplementary treatments was conducted on 160 patients with GI disorders at healthcare institutions in Saïda from March to April 2023 using questionnaires that had been previously adapted and tested for reliability with Cronbach's alpha test.

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters.

Introduction: Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease.

On the behaviour of Atrazine removal from water using fabrics as anodes and cathodes.

This study examines the degradation of atrazine (ATZ) with Pt-modified textile electrodes using an electrochemical method that is comparatively studied in two electrochemical cell configurations: cells with separated anodic and cathodic compartments (divided configuration); and without any separation (undivided configuration). The influence of the presence of chloride ions was studied. The best results were obtained when an undivided cell was used.

Theoretical study by DFT of organometallic complexes based on metallocenes active in NLO.

This study is based on the valuation of a few model molecules. The objective of this research is focused on linear optical (LO) and nonlinear optical (NLO) enhancement of five organometallic molecules based on different metallocenes. These molecules were subjected to several calculations by different long-range functionals CAM-B3LYP, LC-BLYP, LC-wPBE, wB97X, M11, and the following three Minnesota functionals: M06-2X and M08-HX in comparison with the MP2 approach.

Platinum nanoparticles embedded into polyaniline on carbon cloth: improvement of oxygen reduction at cathode of microbial fuel cell used for conversion of medicinal plant wastes into bio-energy.

A microbial fuel cell is a biological electrochemical system that extracts electrons stored in organic matter by oxidation using catalytic properties of microorganisms at bioanode. The major problem in such device, is however limited power production due to slow kinetic of oxygen reduction at cathode. It is worthwhile to develop new materials that fulfil these requirements.

Scratching and transplanting of electro-active biofilm in fruit peeling leachate by ultrasound: re-inoculation in new microbial fuel cell for enhancement of bio-energy production and organic matter detection.

Objective: An electro-active biofilm of Fruit Peeling (FP) leachate was formed onto the Carbon Felt (CF) bio-anode in a Microbial Fuel Cell (MFC), after functioning for a long time. The electro active-biofilm thus formed was then scratched by ultrasound and re-inoculated in a new leachate to be transplanted onto the bio-anode. This procedure allowed the microbial electron charge transfer and therefore the enhancement of the bio-energy production of the fuel cell.

Synthesis and antiproliferative activity of podocarpane and totarane derivatives.

The synthesis of podocarpanes, including 12,19-dihydroxy-13-acetyl-8,11,13-podocarpatriene (23), isolated from Gaultheria yunnanensis and not previously synthesized, and totarane-type terpenoids, starting from the natural labdane trans-communic acid (15), is described. Their antiproliferative activities against MCF-7, T-84 and A-549 human tumoural cell lines are studied. An antiproliferative effect was induced by compounds 23, 27 and 28, with IC < 10 μM in two (27) or three cell lines (23 and 28).

Antiproliferative Activity of Natural Taiwaniaquinoids and Related Compounds.

The in vitro antiproliferative activities of some taiwaniaquinoids and related compounds with functionalized A, B, or C rings against human breast (MCF-7), colon (T-84), and lung (A-549) tumor cell lines were assayed. The most potent compounds, 16, 27, and 36, were more effective than the naturally occurring taiwaniaquinones A (4) and F (5) in all three cell lines. The structure-activity relationship study of these new taiwaniaquinoids highlighted the correlation between the bromo substituent and the antiproliferative activity, especially in MCF-7 cells.

Short Route to Cassane-Type Diterpenoids: Synthesis of the Supposed Structure of Benthaminin 1.

A short route toward aromatic cassane diterpenes from labdane terpenoids has been developed. In the key step, the aromatic ring with the oxygenated function at C-12 and the characteristic carbon group at C-14 of the target compounds is elaborated via a Diels-Alder/aromatization sequence of a furanosesquiterpene and methyl propiolate. On this basis, the synthesis of the proposed structure of benthaminin 1 from trans-communic acid has been achieved.

Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles.

The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.

Polyphenols content of spent coffee grounds subjected to physico-chemical pretreatments influences lignocellulolytic enzymes production by Bacillus sp. R2.

The objective of this study was to investigate the impact of polyphenols content changes issued after physico-chemical treatments of spent coffee grounds on lignocellulolytic enzymes production by Bacillus sp. R2. Total polyphenols of the collected substrates were extracted with water under autoclaving conditions.

Real-Time Control of a Video Game Using Eye Movements and Two Temporal EEG Sensors.

EEG-controlled gaming applications range widely from strictly medical to completely nonmedical applications. Games can provide not only entertainment but also strong motivation for practicing, thereby achieving better control with rehabilitation system. In this paper we present real-time control of video game with eye movements for asynchronous and noninvasive communication system using two temporal EEG sensors.

PDE-based enhancement of color images in RGB space.

A novel method for color image enhancement is proposed as an extension of the scalar-diffusion-shock-filter coupling model, where noisy and blurred images are denoised and sharpened. The proposed model is based on using the single vectors of the gradient magnitude and the second derivatives as a manner to relate different color components of the image. This model can be viewed as a generalization of the Bettahar-Stambouli filter to multivalued images.

3D MRI heart segmentation of mouse embryos.

MRI has become an effective tool for anatomical mice studies. Currently, embryologists study the development of mouse embryos in order to understand the mechanisms of human development. The aim of the research presented in this paper, is to develop a semi-automatic image segmentation framework based 3D deformable models to identify cardiac malformations which are a major cause of death in children.

Nickel-iron layered double hydroxide (LDH): textural properties upon hydrothermal treatments and application on dye sorption.

NiFeCO(3) hydrotalcites with Ni/Fe molar ratio of 3 were synthesized by co-precipitation method at constant pH, followed by hydrothermal treatment at various temperatures 85-180 degrees C for 3-360h. The obtained materials were characterized by XRD analysis, FT-IR spectroscopy, SEM and TEM microscopy, TGA and BET techniques. The resulting materials were found to be similar to the hydrotalcite with a well-defined hexagonal morphology of crystallites.

Reduction of clinkerization temperature by using phosphogypsum.

Valorization of phosphogypsum as mineralizer in the burning of Portland cement clinker was studied in our laboratory. X-ray fluorescence, optical microscope technique and powder X-ray diffraction were then used to characterize the synthesized clinker and its raw mixture in terms of chemical composition and clinker mineralogical composition. The effects of phosphogypsum on structural and morphological properties of clinker minerals and on the presence of alite were followed by scanning electron microscopy combined with microprobe analysis.