Ni-doping effects on formation and migration of oxygen vacancies in SrFeNiO oxygen carriers.

Ni is a promising B-site doping element capable of improving the oxygen carrier performance of SrFeO perovskite. In this work, the effect of Ni doping on the formation and migration of oxygen vacancies in SrFeNiO ( = 0, 0.0625, 0.

ε4 allele status modulates the spatial patterns of progressive atrophy in the temporal lobes after mild traumatic brain injury.

Introduction: We evaluated how the apolipoprotein E () ε4 allele modulated the spatial patterns of longitudinal atrophy in the Alzheimer's disease-vulnerable brain areas of patients with mild traumatic brain injury (mTBI) from the acute to chronic phase post injury.

Methods: Fifty-nine adult patients with acute mTBI and 48 healthy controls with ε4 allele testing underwent T1-weighted magnetic resonance imaging and neuropsychological assessments with 6 to 12 months of follow-up. Progressive brain volume loss was compared voxel-wise in the temporal lobes.

Breaking the trade-off between capacity and stability in vanadium-based zinc-ion batteries.

Water in electrolytes is a double-edged sword in zinc-ion batteries (ZIBs). While it allows for proton insertion in the cathode, resulting in a significant increase in capacity compared to that of organic ZIBs, it also causes damage to electrodes, leading to performance degradation. To overcome the capacity-stability trade-off, organic solvents containing a small amount of water are proposed to mitigate the harmful effects of water while ensuring sufficient proton insertion.

SiO@AuAg/PDA hybrid nanospheres with photo-thermally enhanced synergistic antibacterial and catalytic activity.

Wastewater discharged from industrial, agricultural and livestock production contains a large number of harmful bacteria and organic pollutants, which usually cause serious harm to human health. Therefore, it is urgent to find a "one-stone-two-birds" strategy with good antimicrobial and pollutant degradation activity for treating waste water. In this paper, SiO@AuAg/Polydopamine (SiO@AuAg/PDA) core/shell nanospheres, which possessed synergistic "Ag-release-photothermal" antibacterial and catalytic behaviors, have been successfully prepared a simple redox polymerization method.

First-principles calculations of inorganic metallocene nanowires.

Inspired by the recently synthesized inorganic metallocene derivatives Fe(P), we have identified four stable inorganic metallocene nanowires, MP (M = Sc, Ti, Cr and Fe) in configurations of either regular quadrangular prism (Q-type) or anticube (A-type), and further investigated their magnetic and electronic characteristics utilizing the first-principles calculation. It shows that CrP is a ferromagnetic metal, while other nanowires are semiconducting antiferromagnets with bandgaps of 0.44, 1.

2D-Graph of intermolecular interactions predicts radical character of anion-π* type charge-transfer complexes.

The molecular orbital (MO) theory is one of the most useful methods to describe the formation of a new chemical bond between two molecules. However, it is less often employed for modelling non-bonded intermolecular interactions because of the small charge-transfer contribution. Here we introduce two simple descriptors, the energy difference () of the HOMO of an electron donor and the LUMO of an acceptor against such HOMO-LUMO overlap integral (), to show that the MO theory could give a unified charge-transfer picture of both bonding and non-bonding interactions for two molecules.

Construction of circ_0071922-miR-15a-5p-mRNA network in intervertebral disc degeneration by RNA-sequencing.

Background: Low back pain (LBP) is the main factor of global disease burden. Intervertebral disc degeneration (IVDD) has long been known as the leading reason of LBP. Increasing studies have verified that circular RNAs (circRNAs)-microRNAs (miRNAs)-mRNAs network is widely involved in the pathological processes of IVDD.

Determination of phenolic compounds in water using a multivariate statistical analysis method combined with three-dimensional fluorescence spectroscopy.

Phenolic compounds are toxic chemical pollutants present in water. Three-dimensional fluorescence spectroscopy analysis is an effective and rapid method for real-time phenol monitoring in aquatic environments. However, similar chemical structures of phenols result in highly overlapping three-dimensional fluorescence spectra.

Advances in nerve guidance conduits for peripheral nerve repair and regeneration.

Peripheral nerve injury (PNI) can cause partial or total motor and sensory nerve function, leading to physical disability and nerve pain that severely affects patients' quality of life. Autologous nerve transplantation is currently the clinically recognized gold standard, but due to its inherent limitations, researchers have been searching for alternative treatments. Nerve guidance conduits (NGCs) have attracted much attention as a favorable alternative to promote the repair and regeneration of damaged peripheral nerves.

Static magnetic field assisted thawing improves cryopreservation of mouse whole ovaries.

Ovarian tissue cryopreservation is considered to be the only means to preserve fertility for prepubertal girls and women whose cancer treatment cannot be postponed. However, ovarian tissues are inevitably damaged by oxidative stress during cryopreservation, which threatens follicle survival and development, and thus affects female fertility. Therefore, reducing tissue oxidative stress injury is one of the major challenges to achieving efficient cryopreservation of ovarian tissues, especially for whole ovaries.

Solute-particle separation in microfluidics enhanced by symmetrical convection.

The utilization of microfluidic technology for miniaturized and efficient particle sorting holds significant importance in fields such as biology, chemistry, and healthcare. Passive separation methods, achieved by modifying the geometric shapes of microchannels, enable gentle and straightforward enrichment and separation of particles. Building upon previous discussions regarding the effects of column arrays on fluid flow and particle separation within microchips, we introduced a column array structure into an H-shaped microfluidic chip.

PolyNC: a natural and chemical language model for the prediction of unified polymer properties.

Language models exhibit a profound aptitude for addressing multimodal and multidomain challenges, a competency that eludes the majority of off-the-shelf machine learning models. Consequently, language models hold great potential for comprehending the intricate interplay between material compositions and diverse properties, thereby accelerating material design, particularly in the realm of polymers. While past limitations in polymer data hindered the use of data-intensive language models, the growing availability of standardized polymer data and effective data augmentation techniques now opens doors to previously uncharted territories.

Interlayer Phonon Coupling from Heavy and Light Sublayers in a Natural Van der Waals Superlattice.

Layered compounds characterized by van der Waals gaps are often associated with relatively weak interlayer particle interactions. However, in specific scenarios, these seemingly feeble forces can exert an impact on interlayer interactions through subtle energy fluctuations, which can give rise to a diverse range of physical and chemical properties, particularly intriguing in the context of thermal transport. In this study, taking a natural superlattice composed of alternately stacked PbS and SnS sublayers as a model, we proposed that in a superlattice, there is strong hybridization between acoustic phonons of heavy sublayers and optical phonons of light sublayers.

Long-term immune response to Omicron-specific mRNA vaccination in mice, hamsters, and nonhuman primates.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and its subvariants (such as BQ.1, XBB and the latest variants, including XBB.1.

The preparation and characterization of self-healing hydrogels based on polypeptides with a dual response to light and hydrogen peroxide.

Injectable self-healing hydrogels are being widely used in drug delivery, tissue engineering, and other fields. Because of their excellent biocompatibility and biodegradability, polypeptides are an ideal candidate for preparing injectable self-healing hydrogels. In this study, a polypeptide-based hydrogel with dual response to hydrogen peroxide and light was obtained by copolymerizing 4-arm PEG-amine, -(-nitrophenoxycarbonyl)-l-methionine, and -(-nitrophenoxycarbonyl)-γ--nitrobenzyl-l-glutamate.

Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross-sectional study.

Background And Aims: Leukocytospermia (LCS) is a known cause of male infertility. However, the relationship between seminal leukocytes and semen quality among infertile couples remains controversial. This study aims to investigate the association between semen quality and LCS in male partners of infertile couples.

Advancing nitrate reduction to ammonia: insights into mechanism, activity control, and catalyst design over Pt nanoparticle-based ZrO.

The reduction of nitrogen oxides (NO) to NH, or N represents a crucial step in mitigating atmospheric NO and NO emissions, a significant contributor to air pollution. Among these reduction products, ammonia (NH) holds particular significance due to its utility in nitrogen-based fertilizers and its versatile applications in various industrial processes. Platinum-based catalysts have exhibited promise in enhancing the rate and selectivity of these reduction reactions.

Virtual differential phase-contrast and dark-field imaging of x-ray absorption images via deep learning.

Weak absorption contrast in biological tissues has hindered x-ray computed tomography from accessing biological structures. Recently, grating-based imaging has emerged as a promising solution to biological low-contrast imaging, providing complementary and previously unavailable structural information of the specimen. Although it has been successfully applied to work with conventional x-ray sources, grating-based imaging is time-consuming and requires a sophisticated experimental setup.

Engineering GaN/AuNC core-shell nanowire heterojunctions by gold nanoclusters with excitation-dependent behavior for enhancing the responsivity and stability of self-driven photodetectors.

Self-driven broadband photodetectors (PDs) with low-power consumption have great potential applications in the wide range of next-generation optoelectronic devices. In this study, a self-driven broadband PD responding to an ultraviolet-visible range based on gallium nitride/gold nanocluster (GaN/AuNC) core-shell nanowire heterojunctions is fabricated for the first time. By introducing the AuNCs onto the GaN nanowire surfaces, the GaN/AuNC core-shell nanowire heterojunctions can be formed efficiently.

A mixed-dimensional quasi-1D BiSeI nanowire-2D GaSe nanosheet p-n heterojunction for fast response optoelectronic devices.

Due to the unique combination configuration and the formation of a built-in electric field, mixed-dimensional heterojunctions present fruitful possibilities for improving the optoelectronic performances of low-dimensional optoelectronic devices. However, the response times of most photodetectors built from mixed-dimensional heterojunctions are within the millisecond range, limiting their applications in fast response optoelectronic devices. Herein, a mixed-dimensional BiSeI/GaSe van der Waals heterostructure is designed, which exhibits visible light detection ability and competitive photoresponsivity of 750 A W and specific detectivity of 2.

The pharmacology and therapeutic role of cannabidiol in diabetes.

In recent years, cannabidiol (CBD), a non-psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad pharmacological activity and multi-target effects. Diabetes is a chronic metabolic disease that can damage multiple organs in the body, leading to the development of complications such as abnormal kidney function, vision loss, neuropathy, and cardiovascular disease. CBD has demonstrated significant therapeutic potential in treating diabetes mellitus and its complications owing to its various pharmacological effects.

Bioinspired gradient scaffolds for osteochondral tissue engineering.

Repairing articular osteochondral defects present considerable challenges in self-repair due to the complex tissue structure and low proliferation of chondrocytes. Conventional clinical therapies have not shown significant efficacy, including microfracture, autologous/allograft osteochondral transplantation, and cell-based techniques. Therefore, tissue engineering has been widely explored in repairing osteochondral defects by leveraging the natural regenerative potential of biomaterials to control cell functions.

Atomically Fe-anchored MOF-on-MOF nanozyme with differential signal amplification for ultrasensitive cathodic electrochemiluminescence immunoassay.

The successful application of electrochemiluminescence (ECL) in immunoassays for clinical diagnosis requires stable electrodes and high-efficient ECL signal amplification strategies. Herein, the authors discovered a new class of atomically dispersed peroxidase-like nanozymes with multiple active sites (CoNi-MOF@PCN-224/Fe), which significantly improved the catalytic performance and uncovered the underlying mechanism. Experimental studies and theoretical calculation results revealed that the nanozyme introduced a Fenton-like reaction into the catalytic system and the crucial synergistic effects of definite active moieties endow CoNi-MOF@PCN-224/Fe strong electron-withdrawing effect and low thermodynamic activation energy toward HO.

Targeting mitochondrial degradation by chimeric autophagy-tethering compounds.

The ability to regulate mitophagy in a living system with small molecules remains a great challenge. We hypothesize that adding fragments specific to the key autophagosome protein LC3 to mitochondria will mimic receptor-mediated mitophagy, thus engaging the autophagy-lysosome pathway to induce mitochondrial degradation. Herein, we develop a general biochemical approach to modulate mitophagy, dubbed mito-ATTECs, which employ chimera molecules composed of LC3-binding moieties linked to mitochondria-targeting ligands.