A bispecific antibody targeting the Ig domains of Siglec-E displays enhanced antitumor effects.

Siglec-9 is a promising immune checkpoint molecule, and therapeutics targeting Siglec-9 have the potential to augment anti-tumor immunity. Here, we generated a bispecific antibody, named as aSE4-1-Fc, by fusing two distinct alpaca derived nanobodies, which can simultaneously target the extracellular Ig variable (V)-set domain and C2-set domains of murine Siglec-9 (also known as Siglec-E) with high affinity. In vivo studies showed that aSE4-1-Fc was better than its component antibodies in inhibiting tumor growth/metastasis, and Siglec-E blockade using aSE4-1-Fc generated protective anti-tumor T cell memory.

Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid-β (Aβ) and hyperphosphorylated tau. Identifying the neuropathological changes preceding cognitive decline is crucial for early intervention. Axon initial segment (AIS) maintains the orderly structure of the axon and is responsible for initiating action potentials (APs).

Neoadjuvant chemotherapy plus immunotherapy for locally advanced esophageal cancer.

Objective: This study aimed to explore the efficacy of neoadjuvant chemotherapy plus programmed death-1 (PD-1) inhibitor camrelizumab for the treatment of locally advanced esophageal cancer.

Methods: This was a retrospective analysis. 87 patients with locally advanced esophageal cancer were included who received neoadjuvant chemotherapy plus immunotherapy between June 2018 and April 2021 in our oncology department.

EmbB and EmbC regulate the sensitivity of to echinomycin.

Treatment of (Mab) infections is very challenging due to its intrinsic resistance to most available drugs. Therefore, it is crucial to discover novel anti-Mab drugs. In this study, we explored an intrinsic resistance mechanism through which Mab resists echinomycin (ECH).

Advanced lightweight lightning strike protection composites based on super-aligned carbon nanotube films and thermal-resistant zirconia fibers.

Carbon nanotube films have drawn attention in the past decade as promising substitutes for aluminum or copper used in aircraft lightning strike protection (LSP) systems. Throughout this study, advanced lightweight lightning strike protection (LSP) composites are based on highly conductive super-aligned carbon nanotube films (SA-CNTFs) and a new isolation layer of zirconia fiber paper. The internal damage level of the composite laminate was assessed using a microfocus X-ray system and non-destructive ultrasonic techniques.

Well-Being and Cardiovascular Health: Insights From the UK Biobank Study.

Background: Cardiovascular diseases (CVDs) are a leading global health concern. Emerging evidence suggests a potential protective role of well-being in reducing CVD risk.

Methods And Results: We conducted a cohort analysis using the UK Biobank data set, encompassing 121 317 participants.

Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and insights into targeting glucose metabolism in human lung cancer.

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3. Thus, inhibiting GLUTs holds promise as an anticancer therapy by starving these cells of fuel.

Unexpected and divergent mechanosynthesis of furanoid-bridged fullerene dimers CO and CO.

An unexpected, divergent and efficient approach toward furanoid-bridged fullerene dimers CO and CO was established under different solvent-free ball-milling conditions by simply using pristine C as the starting material, water as the oxygen source and FeCl as the mediator. The structures of CO and CO were unambiguously established by single-crystal X-ray crystallography. A plausible reaction mechanism is proposed on the basis of control experiments.

Biomimetic engineering of a neuroinflammation-targeted MOF nanozyme scaffolded with photo-trigger released CO for the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is one of the most fatal and irreversible neurodegenerative diseases, which causes a huge emotional and financial burden on families and society. Despite the progress made with recent clinical use of inhibitors of acetylcholinesterase and amyloid-β (Aβ) antibodies, the curative effects of AD treatment remain unsatisfactory, which is probably due to the complexity of pathogenesis and the multiplicity of therapeutic targets. Thus, modulating complex pathological networks could be an alternative approach to treat AD.

Bioimaging and prospects of night pearls-based persistence phosphors in cancer diagnostics.

Inorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With the prominent advantages of near-infrared light, such as deep penetration, high resolution, low autofluorescence, and tissue absorption, persistent phosphors can be used for deep bioimaging. We focus on highlighting inorganic persistent phosphors, emphasizing the synthesis methods and applications in cancer diagnostics.

A Novel Automated Aspiration of Subretinal Fluid Method During Scleral Buckling For Rhegmatogenous Retinal Detachment.

Purpose: The goal of the study is to introduce a modified technique for the removal of subretinal fluid during scntleral buckling (SB) to treat rhegmatogenous retinal detachment (RRD).

Methods: This case series study was comprised of 18 cases of RRD patients suffering from a novel automated aspiration of subretinal fluid method during SB. The cases took place from July 2023 to November 2023 at the First Affiliated Hospital of USTC.

Realizing altermagnetism in two-dimensional metal-organic framework semiconductors with electric-field-controlled anisotropic spin current.

Altermagnets exhibit momentum-dependent spin-splitting in a collinear antiferromagnetic order due to their peculiar crystallographic and magnetic symmetry, resulting in the creation of spin currents with light elements. Here, we report two two-dimensional (2D) metal-organic framework (MOF) semiconductors, M(pyz) (M = Ca and Sr, pyz = pyrazine), which exhibit both altermagnetism and topological nodal point and line by using first-principles calculations and group theory. The altermagnetic 2D MOFs exhibit unconventional spin-splitting and macroscopic zero magnetization caused by 4-fold rotation in crystalline real space and 2-fold rotation in spin space, leading to the generation and control of anisotropic spin currents when an in-plane electric field ( ) is applied.

Breaking the scaling relations of effective CO electrochemical reduction in diatomic catalysts by adjusting the flow direction of intermediate structures.

The electrocatalytic carbon dioxide reduction reaction (CORR) is a promising approach to achieving a sustainable carbon cycle. Recently, diatomic catalysts (DACs) have demonstrated advantages in the CORR due to their complex and flexible active sites. However, our understanding of how DACs break the scaling relationship remains insufficient.

Electron Deficiency is More Important than Conductivity in C-N Coupling for Electrocatalytic Urea Synthesis.

The electrocatalytic C-N coupling from CO and nitrate emerges as one of the solutions for waste upgrading and urea synthesis. In this work, we constructed electron-deficient Cu sites by the strong metal-polymer semiconductor interaction, to boost efficient and durable urea synthesis. In situ Raman spectroscopy identified the existence of electron-deficient Cu sites and was able to withstand electrochemical reduction conditions.

Multi-electron redox reactivity of a samarium(ii) hydrido complex.

Well-defined low-valent molecular rare-earth metal hydrides are rare, and limited to Yb and Eu centers. Here, we report the first example of the divalent samarium(ii) hydrido complex [(Cp)Sm(μ-H)(DABCO)] (4) (Cp = CAr, Ar = 3,5-Pr-CH; DABCO = 1,4-diazabicyclooctane) supported by a super-bulky penta-arylcyclopentadienyl ligand, resulting from the hydrogenolysis of the samarium(ii) alkyl complex [(Cp)Sm{CH(SiMe)}(DABCO)] (3). Complex 4 exhibits multi-electron redox reactivity toward a variety of substrates.

Leveraging phenazine and dihydrophenazine redox dynamics in conjugated microporous polymers for high-efficiency overall photosynthesis of hydrogen peroxide.

Harnessing solar energy for hydrogen peroxide (HO) production from water and oxygen is crucial for sustainable solar fuel generation. Conjugated microporous polymers (CMPs), with their vast structural versatility and extended π-conjugation, are promising photocatalysts for solar-driven HO generation, though enhancing their efficiency is challenging. Inspired by the crucial role of phenazine derives in biological redox cycling and electron transfer processes, the redox-active phenazine moiety is rationally integrated into a CMP framework (TPE-PNZ).

Ozone Mortality Burden Changes Driven by Population Aging and Regional Inequity in China in 2013-2050.

Air pollution exposure is closely linked to population age and socioeconomic status. Population aging and imbalance in regional economy are thus anticipated to have important implications on ozone (O)-related health impacts. Here we provide a driver analysis for O mortality burden due to respiratory disease in China over 2013-2050 driven by population aging and regional inequity.

Local electric field in nanocavities dictates the vibrational relaxation dynamics of interfacial molecules.

Plasmonic nanocavities enable the generation of strong light-matter coupling and exhibit great potential in plasmon-mediated chemical reactions (PMCRs). Although an electric field generated by nanocavities ( ) has recently been reported, its effect on the vibrational energy relaxation (VER) of the molecules in the nanocavities has not been explored. In this study, we reveal the impact of an electric field sensed by molecules (-substituted thiophenol derivatives) in a nanocavity ( ) on VER processes by employing advanced time-resolved femtosecond sum frequency generation vibrational spectroscopy (SFG-VS) supplemented by electrochemical measurements.

bioorthogonal-modulation of mA RNA methylation in macrophages for efficient eradication of intracellular bacteria.

N-Methyladenosine (mA) methylation plays a critical role in controlling the RNA fate. Emerging evidence has demonstrated that aberrant mA methylation in immune cells such as macrophages could alter cell homeostasis and function, which can be a promising target for disease treatment. Despite tremendous progress in regulating the level of mA methylation, the current methods suffer from the time-consuming operation and annoying off-target effect, which hampers the manipulation of mA methylation.

J-aggregates of strong electron-donating groups linked Aza-BODIPY adjusting by polypeptide for NIR-II phototheranostics.

The commonly employed strategies for engineering second near-infrared (NIR-II) organic phototheranostic agents are based on expanding conjugated backbone length, strengthening donor (D)-acceptor (A) effect, or forming J-aggregates. We constructed the D-A-D' structure by incorporating strong electron-donating methoxy and tetraphenylethene (TPE) moieties on the electron-deficient Aza-BODIPY core, and simultaneously expanded the π-conjugation effect by introducing thiophene groups, to obtain a dye BDP-TPE. Next, the nanoparticles P-TPE were prepared via the assembly of BDP-TPE with amphiphilic polypeptides (mPEG-P(Asp)), and successfully constructed the J-aggregates.