6 results match your criteria: "University of Science and Technology of China (UTSC)[Affiliation]"
Functional roles of conserved lncRNAs and circRNAs in eukaryotes.
Noncoding RNA Res
December 2024
Department of Clinical Laboratory, The First Affiliated Hospital of USTC, The RNA Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, Anhui, China.
Article Synopsis
- Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are essential regulators involved in various biological processes in eukaryotes.
- These non-coding RNAs function by influencing chromatin structure, regulating transcription, interacting with RNA-binding proteins, and acting as microRNA sponges.
- Studying conserved lncRNAs and circRNAs across different species can help deepen our understanding of their roles and mechanisms, which is often limited when focusing on just one species.
CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages.
Cardiovasc Res
November 2024
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Aims: Circular RNAs (circRNAs) are considered important regulators of biological processes, but their impact on atherosclerosis development, a key factor in coronary artery disease (CAD), has not been fully elucidated. We aimed to investigate their potential use in patients with CAD and the pathogenesis of atherosclerosis.
Methods And Results: Patients with stable angina (SA) or acute coronary syndrome (ACS) and controls were selected for transcriptomic screening and quantification of circRNAs in blood cells.
Identification of long non-coding RNA and circular RNA associated networks in cellular stress responses.
Front Genet
February 2023
Department of Clinical Laboratory, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, Anhui, China.
Article Synopsis
- Mammalian cells use various adaptive responses to maintain balance during stress, and non-coding RNAs (ncRNAs) play a significant role in this process, requiring more research on their interactions.
- HeLa cells were exposed to stressors like thapsigargin and glucose deprivation, leading to observed changes in long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that respond similarly to both stress types.
- The study created networks showing how lncRNAs and circRNAs can regulate gene expression and interact with other RNA molecules, shedding light on their roles in cellular stress responses.
The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis.
J Transl Med
September 2022
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Article Synopsis
- Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease, and recent studies highlight the potential role of circular RNAs, specifically mitochondria-encoded circRNAs (mecciRNAs), in its progression.
- Using various gene expression databases and analysis techniques, the study investigated differentially expressed mecciRNAs in NASH, their interaction with other RNAs, and identified immune subtypes of the disease.
- The research revealed that specific mecciRNAs can act as competing endogenous RNAs, influencing fibrosis-related signals and leading to the identification of 21 core genes, indicating distinct clusters among NASH patients based on their inflammatory signals.
Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance.
J Exp Clin Cancer Res
July 2022
High Magnetic Field Laboratory, Hefei Institutes of Physical Science (HIPS), Chinese Academy of Sciences, Hefei, 230031, Anhui, China.
Article Synopsis
- * Covalently closed circular RNAs (circRNAs) have been recognized as important regulators in various cancers, including GC, and show altered patterns in GC that contribute to its invasion and spread.
- * The paper aims to explore the roles of circRNAs in GC metastasis and drug resistance, discussing their mechanisms and potential as targets for future therapies.
Circular RNAs in physiology and non-immunological diseases.
Trends Biochem Sci
March 2022
Department of Clinical Laboratory, First Affiliated Hospital of the USTC, Hefei National Laboratory for Physical Sciences at Microscale, Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, China; Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. Electronic address:
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs. Four subclasses of circRNAs have been identified in animal cells, and they have unique features in their biogenesis, degradation, and transport. CircRNAs have diverse molecular functions in sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins.
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