Bipolar Solid-Solution Hosts for Efficient Crystalline Organic Light-Emitting Diodes.

Crystalline organic semiconductors, recognized for their highly ordered structures and high carrier mobility, have emerged as a focal point in the field of high-performance optoelectronic devices. Nevertheless, the intrinsic unipolar properties, characterized by imbalanced hole and electron transport capabilities, have continuously represented a significant challenge in the advancement of high-performance crystalline thin-film organic light-emitting diodes (C-OLEDs). Here, a bipolar solid-solution thin film with a maintained crystal structure has been fabricated using 2-(4-(9H-carbazol-9-yl)phenyl)-1(3,5-difluorophenyl)-1H-phenanthro [9,10-d]imidazole (2FPPICz) and 4-(1-(3,5-difluorophenyl)-1H-imidazo[4,5-][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline (2Fn) via a weak epitaxial growth (WEG) process, exhibiting nearly equivalent hole and electron mobilities (10-10 cm V s).

Attention-Based Interpretable Multiscale Graph Neural Network for MOFs.

Metal-organic frameworks (MOFs) hold great potential in gas separation and storage. Graph neural networks (GNNs) have proven effective in exploring structure-property relationships and discovering new MOF structures. Unlike molecular graphs, crystal graphs must consider the periodicity and patterns.

Proton-Controlled Electron Injection in MoS During Hydrogen Evolution Revealed by Time-Resolved Spectroelectrochemistry.

Monolayer MoS is an effective electrocatalyst for the hydrogen evolution reaction (HER). Despite significant efforts to optimize the active sites, its catalytic performance still falls short of theoretical predictions. One key factor that has often been overlooked is the electron injection from the conductive substrate into the MoS.

Prenatal Diagnosis of Berry Syndrome by Fetal Echocardiography.

Berry syndrome is a rare combination of cardiac malformations, which is characterized by the following malformations, including the aortopulmonary window, aortic right pulmonary origin, interrupted aortic arch or hypoplastic aortic arch or coarctation of the aorta, and an intact ventricular septum. There are few reviews on prenatal diagnosis of Berry syndrome by fetal echocardiography. We used sequential cross-sectional scanning from apex to bottom of the heart to find aortic right pulmonary origin, aortopulmonary window, and hypoplastic aortic arch.

Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.

Prosocial behaviors are advantageous to social species, but the neural mechanism(s) through which others receive benefit remain unknown. Here, we found that bystander mice display rescue-like behavior (tongue dragging) toward anesthetized cagemates and found that this tongue dragging promotes arousal from anesthesia through a direct tongue-brain circuit. We found that a direct circuit from the tongue → glutamatergic neurons in the mesencephalic trigeminal nucleus (MTN) → noradrenergic neurons in the locus coeruleus (LC) drives rapid arousal in the anesthetized mice that receive the rescue-like behavior from bystanders.

Electronic structure of superconducting infinite-layer lanthanum nickelates.

Revealing the momentum-resolved electronic structure of infinite-layer nickelates is essential for understanding this class of unconventional superconductors but has been hindered by the formidable challenges in improving the sample quality. In this work, we report the angle-resolved photoemission spectroscopy of superconducting LaSrNiO films prepared by molecular beam epitaxy and in situ atomic-hydrogen reduction. The measured Fermi topology closely matches theoretical calculations, showing a large Ni [Formula: see text]-derived Fermi sheet that evolves from hole-like to electron-like along and a three-dimensional (3D) electron pocket centered at the Brillouin zone corner.

Metal-organic cages improving microporosity in polymeric membrane for superior CO capture.

Mixed matrix membranes, with well-designed pore structure inside the polymeric matrix via the incorporation of inorganic components, offer a promising solution for addressing CO emissions. Here, we synthesized a series of novel metal organic cages (MOCs) with aperture pore size precisely positioned between CO and N or CH. These MOCs were uniformly dispersed in the polymers of intrinsic microporosity (PIM-1).

Triple knockdown of , , and in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice.

Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the landscape of cancer treatment, in particular in the context of hematologic malignancies. However, for solid tumors that lack tumor-specific antigens, CAR-T cells can infiltrate and attack nonmalignant tissues expressing the CAR target antigen, leading to on-target, off-tumor toxicity. Severe on-target, off-tumor toxicities have been observed in clinical trials of CAR-T therapy for solid tumors, highlighting the need to address this issue.

Monomer Design Enables Mechanistic Mapping of Anionic Ring-Opening Polymerization of Aromatic Thionolactones.

Degradable chalcogenide polyesters, e.g., polythioesters (PTEs), typically exhibit improved thermal, mechanical, and optical properties.

Intrinsic Solution to the Dilemma between High-Efficiency and External-Field-Free Spin-Orbit Torque Switching Based on Biaxial Devices.

Spin-orbit torque (SOT) is widely considered to be a fast and robust writing scheme for magnetic random-access memories (MRAMs). However, the requirements of field-free switching and high switching efficiency are often incompatible in SOT devices, placing a critical challenge on its improvement. Here we propose that by utilizing biaxial systems the dilemma between high-efficiency and external-field-free SOT switching can be solved intrinsically.

Super-Resolution Fluorescence Imaging Reveals the Mechanism of NRP1 Clustering on Non-Small-Cell Lung Cancer Membranes.

Neuropilin 1 (NRP1) is upregulated in various types of malignant tumors, especially non-small-cell lung cancer (NSCLC). However, the precise mechanisms for membrane localization and regulation are not fully understood. Observations from super-resolution microscopy have revealed that NRP1 tends to form nanoscale clusters on the cell membrane, with these clusters varying significantly in size and density across different regions.

α-ZnO Manipulated Growth of Ag Gird on AgNWs Enables High Conductive Flexible Electrode for Large-Area Monolithic Organic Photovoltaics.

The conductivity of AgNWs electrodes can be enhanced by incorporating Ag grids, thereby facilitating the development of large-area flexible organic solar cells (FOSCs). Ag grids from vacuum evaporation offer the advantages of simple film formation, adjustable thickness, and unique structure. However, the complex 3D multi-component structure of AgNWs electrodes will exacerbate the aggregation of large Ag particles, causing the device short circuits.

Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.

Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells.

Relationship between BDNF content in cord blood and early neurobehavior in newborns with subclinical hypothyroidism during pregnancy: a preliminary study.

Objectives: Research on neurobehavioral abnormalities in neonates of mothers with subclinical hypothyroidism (SCH) is limited. The link between umbilical cord blood brain-derived neurotrophic factor (BDNF) levels and neurobehavioral outcomes in neonates has not been explored. This study investigates the correlation between alterations in umbilical cord blood BDNF levels and early neurobehavioral abnormalities in neonates born to pregnant women with SCH.

Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.

Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk.

Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.

Objective: Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.

Method: A total of 1485 participants were recruited from a university hospital between April 2020 and August 2022.

Mass production of robust hydrogel electrolytes for high-performance zinc-ion batteries.

Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cycles of mechanical loads while maintaining high electrochemical performance needed for the new-generation flexible zinc-ion batteries. Herein, we present a superspreading-based strategy to produce robust hydrogel electrolytes consisting of polyvinyl alcohol, sodium alginate and sodium acetate.

Sargassum Nanocellulose-Based Fully Ingestible Supercapacitor.

Small high-performance energy modules have significant practical value in the biomedical field, such as painless diagnosis, alleviation of gastrointestinal discomfort, and electrical stimulation therapy. However, due to performance limitations and safety concerns, it is a formidable challenge to design a small, emerging ingestible power supply. Here, a fully ingestible supercapacitor (FISC) constructed of sargassum cellulose nanofiber is presented.

LGALS3BP: A Potential Prognostic Biomarker Influencing Antitumor Immunity in Triple-negative Breast Cancer.

Objective: LGALS3BP exhibits differential expression in various types of tumors. This study aimed to analyze its potential diagnostic and prognostic value in Triple- negative Breast Cancer (TNBC).

Methods: We conducted a comprehensive analysis of LGALS3BP's differential expression and its association with patient survival outcomes using data from public databases.

Short-term variability of Alzheimer's disease plasma biomarkers in a mixed memory clinic cohort.

Background: For clinical implementation of Alzheimer's disease (AD) blood-based biomarkers (BBMs), knowledge of short-term variability, is crucial to ensure safe and correct biomarker interpretation, i.e., to capture changes or treatment effects that lie beyond that of expected short-term variability and considered clinically relevant.

Oceanic evasion fuels Arctic summertime rebound of atmospheric mercury and drives transport to Arctic terrestrial ecosystems.

Mercury (Hg) contamination poses a persistent threat to the remote Arctic ecosystem, yet the mechanisms driving the pronounced summer rebound of atmospheric gaseous elemental Hg (Hg) and its subsequent fate remain unclear due to limitations in large-scale seasonal studies. Here, we use an integrated atmosphere-land-sea-ice-ocean model to simulate Hg cycling in the Arctic comprehensively. Our results indicate that oceanic evasion is the dominant source (~80%) of the summer Hg rebound, particularly driven by seawater Hg release facilitated by seasonal ice melt (~42%), with further contributions from anthropogenic deposition and terrestrial re-emissions.

Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography.

Electron ptychography, recognized as an ideal technique for low-dose imaging, consistently achieves deep sub-angstrom resolution at electron doses of several thousand electrons per square angstrom (e/Å) or higher. Despite its proven efficacy, the application of electron ptychography at even lower doses-necessary for materials highly sensitive to electron beams-raises questions regarding its feasibility and the attainable resolution under such stringent conditions. Herein, we demonstrate the implementation of near-atomic-resolution ( ~ 2 Å) electron ptychography reconstruction at electron doses as low as ~100 e/Å, for metal-organic frameworks (MOFs), which are known for their extreme sensitivity.

Enhanced solar hydrogen production via reconfigured semi-polar facet/cocatalyst heterointerfaces in GaN/Si photocathodes.

The development of an efficient and durable photoelectrode is critical for achieving large-scale applications in photoelectrochemical water splitting. Here, we report a unique photoelectrode composed of reconfigured gallium nitride nanowire-on-silicon wafer loaded with Au nanoparticles as cocatalyst that achieved an impressive applied bias photon-to-current efficiency of 10.36% under AM 1.

Boosting selective chlorine evolution reaction: Impact of Ag doping in RuO electrocatalysts.

The chlor-alkali process is critical to the modern chemical industry because of the wide utilization of chlorine gas (Cl). More than 95 % of global Cl production relies on electrocatalytic chlorine evolution reaction (CER) through chlor-alkali electrolysis. The RuO electrocatalyst serves as the main active component widely used in commercial applications.