Assessment of responses of cultured benthic foraminiferal communities to copper pollution through environmental RNA metabarcoding analysis.

Copper (Cu) is an essential trace element and can accumulate in sedimentary environments. However, beyond a certain concentration threshold, Cu can pose toxicity risks to biota. Benthic foraminifera are widely distributed and exhibit characteristics such as high biodiversity, short life cycle, good preservation potential, and high pollutant sensitivity, making them good bioindicators.

Recent advances in green multi-component reactions for heterocyclic compound construction.

Multi-component reactions (MCRs) are processes in which three or more reactants are introduced into one pot to obtain the final product with high atom efficiency, and in recent years, these have become a key strategy for advancing more sustainable processes in modern synthetic communities and the pharmaceutical industry. Meanwhile, minimizing the use of solvents, catalysts, time, reagents, and waste is essential during green chemical synthesis to reduce cost and environmental impact. Heterocycles are ubiquitous and have thus prompted the development of numerous methods for their synthesis.

Superhydrophobic Luminescent Pixel Array Based on Perovskite Quantum Dots for Outdoor Displays.

Perovskite quantum dots (PQDs) have garnered significant attention in the display industry as high-performance luminescent materials in recent years. However, in outdoor applications, it is highly challenging to maintain the luminescent performance of PQDs while simultaneously ensuring superhydrophobicity and self-cleaning functionality in rainy weather conditions. Here, we report a luminescent pixel array fabricated using superhydrophobic PQDs with a photoluminescence quantum yield (PLQY) of 32%.

CRISPR-guided base editor enables efficient and multiplex genome editing in bacterial cellulose-producing species.

Unlabelled: Bacterial cellulose (BC) is an extracellular polysaccharide produced by bacteria that has wide applications in the food industry, tissue engineering, and battery manufacturing. Genome editing of BC-producing species is expected to optimize BC production and its properties. However, the available technology can target only one gene at a time and requires foreign DNA templates, which may present a regulatory hurdle for genetically modified organisms.

Molecular Dynamics Simulation of the Hydration Lubrication Mechanism of CS-MPC/CS-ChS NPs.

Osteoarthritis (OA) remains a significant clinical challenge, with current treatments like sodium hyaluronate injections offering limited efficacy due to suboptimal lubrication and rapid degradation. In this study, we explored an advanced solution to these issues by investigating the colubrication mechanism of a composite biolubricant consisting of 2-methacryloyloxyethyl phosphorylcholine-modified chitosan (CS-MPC) and chondroitin sulfate-modified chitosan nanoparticles (CS-ChS NPs) using molecular dynamics (MD) simulations. Results show that the composite lubricant outperforms individual CS-MPC or CS-ChS NPs, exhibiting a lower coefficient of friction (COF) and a superior load-bearing capacity.

A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml-1 and PI-RADS 1-3.

We propose a strategy to reduce unnecessary prostate biopsies in Chinese patients with total prostate-specific antigen (tPSA) >10 ng ml-1 and Prostate Imaging Reporting and Data System (PI-RADS) scores between 1 and 3. Clinical data derived from 517 patients of The First Affiliated Hospital of USTC (Hefei, China) from January 2020 to December 2023 who met the screening criteria for the study were retrospectively collected. Independent predictors were identified via univariate and multivariate logistic regression analysis.

[The importance of the diet in the prevention of atherosclerosis progression].

The most common mechanism of the development of cardiovascular diseases is atherosclerosis, caused by genetic predisposition, hyperlipidemia, inflammation and metabolic disorders. Statins used in medicine inhibit endogenous cholesterol synthesis, but are characterized by diabetogenic effect, development of intolerance in 9.1%, and muscle symptoms in 10-25% of patients.

Salutogenic Architecture, Non-Therapeutic Environments and the Health of the Elderly: A Systematic Review.

Despite a lot of studies that have been conducted on the effects of the built environment on the health of the elderly and environmental salutogenic factors, a limited number of studies have investigated the architectural physical factors clearly. This paper investigated the architectural elements in the non-therapeutic built environment that can achieve salutogenic goals for the elderly. It also aimed to provide an answer to the question of how architectural design might be used to physically bring salutogenic theory to life.

The Application of Benziodazole-Type ONO-I(III) Compound as a Nitrating Reagent for Nitration of Phenols and Anilines.

A benziodazole-type ONO-I(III) compound was used as a nitrating reagent to react with a series of electron-rich arenes including substituted phenols and anilines, affording the corresponding nitration products under mild conditions. Mechanistically, ONO-I(III) compound generates the reactive nitrogen dioxide (NO) species, which enables the nitration of phenols and anilines.

Depression among outpatients with diabetic peripheral neuropathy: prevalence and associated factors.

Aim: This study aims to assess the prevalence of depression among patients with diabetic neuropathy and identify contributing factors.

Methods: A cross-sectional descriptive design was used, recruiting 153 patients from outpatient clinics. Participants completed the Beck Depression Inventory II, Michigan Neuropathy Screening Instrument, and Douleur Neuropathique 4 questionnaires, with recent A1C results obtained from medical records.

Chromosome-Scale Assembly of Capsella orientalis, Maternal Progenitor of Cosmopolitan Allotetraploid C. bursa-pastoris.

The genus Capsella serves as a model for understanding speciation, hybridization, and genome evolution in plants. Here, we present a chromosome-scale genome assembly of Capsella orientalis, the maternal progenitor of a cosmopolitan allotetraploid C. bursa-pastoris.

First genome sequence of a purple sulphur bacterium of the genus , its characterization as a new isolate of and proposal of strain Um2 as neotype of this species.

A new alkaliphilic strain of a purple sulphur bacterium designated as Um2 (=KCTC 25734=VKM B-3893=UQM 41073) with bacteriochlorophyll and internal photosynthetic membranes of tubular type was isolated from the Umhei hydrothermal system (40 °C, pH 9.3 and salinity 0.42 g l) located in the Baikal rift zone (Russia).

Scalable and Durable Superhydrophobic Coating Using Shellac-Based Bioadhesive and Hierarchical Silica Nanoparticles.

Superhydrophobic coatings have broad applications across various fields but often face challenges, such as complexity, high cost, low mechanical/thermal stability, toxicity, and environmental hazards. In this study, we demonstrate a simple, scalable, eco-friendly, and durable spray-coating method using bioadhesive shellac and octadecyltrichlorosilane (OTS)-modified silica nanoparticles to create superhydrophobic surfaces. The silica nanoparticles impart superhydrophobicity by forming hierarchical micro/nanostructures and reducing surface free energy, while shellac ensures strong adhesion of the nanoparticles to a wide range of substrates, including nonwoven polypropylene fibers, glass, plastic, metal, wood, cotton, and concrete.

Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth.

Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or inhibit checkpoint kinases involved in the DNA damage response. Thus far, treatments that combine these two strategies have shown promise but also have severe adverse effects.

Accelerated Design of Dual-Metal-Site Catalysts via Machine-Learning Prediction.

Dual-metal site catalysts (DMSCs) supported on nitrogen-doped graphene have shown great potential in heterogeneous catalysis due to their unique properties and enhanced efficiency. However, the precise control and stabilization of metal dimers, particularly in oxygen activation reactions, present significant challenges in practical applications. In this study, we integrate high-throughput density functional theory calculations with machine learning techniques to predict and optimize the catalytic properties of DMSCs.

Life's Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes.

Aims: To assess whether better cardiovascular health is associated with a lower long-term risk of CVD in women with a history of adverse pregnancy outcomes (APOs).

Methods: Using data from the UK Biobank prospective cohort, we included 2,263 participants with prior APOs and 107,260 participants without prior APOs. Life's Essential 8 (LE8) score was assessed at baseline.

Neutrophil- Interaction Induces Neutrophil Extracellular Traps, DAMPs, and Inflammatory Molecule Release.

Neutrophils, the first cells to arrive at infection sites, release neutrophil extracellular traps (NETs) comprising nuclear and/or mitochondrial DNA webs decorated with proteins. Similar to other parasites, induces NET extrusion. However, our understanding of NET formation and neutrophil fate after NET release in a Leishmania infection context is limited.

Seminal plasma metabolomics and sperm lipidomics profiles of bull semen with different total progressive motile sperm count.

Total progressive motile sperm count (TPMSC) is a reliable index of fecundity evaluation of bull semen. It is an important determinant frozen semen yield and conception rate of females artificially inseminated. Seminal plasma metabolites and sperm lipids are closely related to sperm survival and motility, but their relationship with TPMSC is not well known.

A new steroid from G2131.

A comprehensive study was carried out on G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (), four known compounds: demethylincisterol A (), (22, 24 )-ergosta-7,9(11),22-trien-3-ol (), (22,24)-5,8-epidixyer-gosta-6,22-dien-3-ol () and - hydroxybenzaldehyde (). The structure of compound was determined using a variety of spectroscopic methods such as H spectrum,C spectrum, HMBC, HSQC,H-H COSY, LC-MS, UV, IR and comparison of their NMR data with literature.

A Bacteria-Responsive Multifunctional Nanohydrogel for Recognition of Bacterial Infections and Activable Four-in-One Antibacterial Therapy.

Bacterial infections have long been a formidable challenge in global public health, further compounded by the emergence of drug-resistant bacteria resulting from the overuse and misuse of antibiotics. Intelligent antibacterial strategies are garnering escalating attention and concern due to their ability to accurately recognize bacterial infections, efficiently eliminate pathogens, and timely monitor infection end points in order to mitigate the adverse effects of excessive treatment on normal tissues. Hence, in this study, we developed a multifunctional antibacterial nanohydrogel that exhibited bacteria-triggered fluorescence activity, serving as a fluorescent indicator for bacterial infections.

Size Inhomogeneity Facilitates Exciton Dissociation in Carbon Dots.

Organic carbon dots (CDs) exhibit tunable electronic structures and exceptional optical properties, supporting both exciton- and charge-driven applications. However, the mechanisms underlying this dual functionality are poorly understood. This study establishes the role of size inhomogeneity in exciton dissociation for the first time.

Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges.

As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response to food fluctuations throughout evolution. However, the mechanisms governing this resilience remain incompletely understood. In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting.

Transcriptomic analysis of long non-coding RNA and mRNA in pigeon squab pectoralis muscle development.

1. As one of the most widespread poultry species in the world, pigeons have been bred primarily for meat production due to their high nutritional value and good taste. Their breast muscle is an important economic product as it determines the yield and quality of meat from pigeons.

Correction: Inhibitory effects of Atlantic cod () peptides on RANKL-induced osteoclastogenesis and osteoporosis in ovariectomized mice.

Correction for 'Inhibitory effects of Atlantic cod () peptides on RANKL-induced osteoclastogenesis and osteoporosis in ovariectomized mice' by Meilian Yang , , 2022, , 1975-1988, https://doi.org/10.1039/D1FO03696C.