3D-Printed PCL/SrHA@DFO Bone Tissue Engineering Scaffold with Bone Regeneration and Vascularization Function.

The application of a three-dimensional (3D)-printed biological functional scaffold in the repair of bone defects is a promising strategy. In this study, strontium-containing hydroxyapatite (SrHA) powder was synthesized by the hydrothermal method, and then poly(ε-caprolactone) (PCL)/HA and PCL/SrHA composite scaffolds were prepared by the high-temperature melt extrusion 3D printing technology. The basic physical and chemical properties, in vitro biological properties, osteogenesis, and angiogenesis abilities of the scaffold were studied.

Synthesis and evaluation of KX-01 analogs with an exploration of linker attachment points for antibody-drug conjugates.

KX-01 (tirbanibulin, Klisyri®) is a recently FDA-approved drug for treating actinic keratosis, with a distinct dual mechanism of action combining microtubule disruption and non-ATP-competitive Src inhibition. This unique mechanism and novel chemotype highlight KX-01's potential as a payload for antibody-drug conjugates. In this study, we synthesized and evaluated KX-01 derivatives to enhance anticancer potency and explore functional groups suitable for antibody conjugation.

LG1 promotes preligule band formation through directly activating ZmPIN1 genes in maize.

Increasing plant density is an effective strategy for enhancing crop yield per unit land area. A key architectural trait for crops adapting to high planting density is smaller leaf angle (LA). Previous studies have demonstrated that LG1, a SQUAMOSA BINDING PROTEIN (SBP) transcription factor, plays a critical role in LA establishment.

Enhancing single-stage partial nitritation-anammox process with airlift inner-circulation and oxygen partition: a novel strategy for treating high-strength ammonium wastewater.

In the single-stage partial nitritation-anammox process for high-ammonium wastewater treatment, the presence of sufficient biomass with high activity is essential. This study developed an innovative airlift inner-circulation partition bioreactor (AIPBR) with a dual-cylinder structure. During the 362 days' operation, the AIPBR exhibited robust and stable nitrogen removal performance under diverse influent ammonium spanning from 300 to 1800 mg N/L.

The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family.

Background: Lung adenocarcinoma is one of the most common malignant tumors worldwide. Its complex molecular mechanisms and high tumor heterogeneity pose significant challenges for clinical treatment. The manganese ion metabolism family plays a crucial role in various biological processes, and the abnormal expression of the NUDT3 gene in multiple cancers has drawn considerable attention.

Role of VDAC1 in hepatocyte apoptosis during acute liver injury in rats induced by obstructive jaundice.

Objectives: Exploring the role of VDAC1 in hepatocyte apoptosis during acute liver injury induced by obstructive jaundice.

Materials And Methods: Animal and cell models were established to investigate possible mechanisms during acute liver injury induced by OJ. Blood was collected for liver function assessment.

Harmonic analysis and optimization for closed-loop superconducting shim coils of 7 T MRI magnet.

Background: High-resolution brain imaging is crucial in clinical diagnosis and neuroscience, with ultra-high field strength MRI systems ( ) offering significant advantages for imaging neuronal microstructures. However, achieving magnetic field homogeneity is challenging due to engineering faults during the installation of superconducting strip windings and the primary magnet.

Purpose: This study aims to design and optimize active superconducting shim coils for a 7 T animal MRI system, focusing on the impact of safety margin, size, and adjustability of the second-order shim coils on the MRI system's optimization.

The prevalence of PD-L1 expression in patients with advanced oesophageal cancer: the EXCEED observational study.

Aims: There are limited data on programmed death ligand 1 (PD-L1) expression in oesophageal cancer (OC) from multicentre studies conducted across China. We aimed to determine the prevalence of high PD-L1 expression in patients with advanced OC.

Methods: The EXCEED study was a multicentre, retrospective analysis of data from six tertiary hospitals that evaluated PD-L1 expression in adults with advanced OC or advanced head and neck squamous cell carcinoma.

Organic acid release and microbial community assembly driven by phosphate-solubilizing bacteria enhance Pb, Cd, and As immobilization in soils remediated with iron-doped hydroxyapatite.

Although iron-doped hydroxyapatite (Fe-HAP) and its composites have been reported to immobilize arsenic (As), lead (Pb), and cadmium (Cd), its practical application is limited by the inefficient release of iron and phosphate. In this study, Ochrobactrum anthropic, a phosphate-solubilizing bacterium isolated from a lead-zinc smelting site, was employed to enhance multi-heavy metal immobilization in Fe-HAP-amended soils. O.

Fractional Spinon Quasiparticles in Open-Shell Triangulene Spin-1/2 Chains.

The emergence of spinon quasiparticles, which carry spin but lack charge, is a hallmark of collective quantum phenomena in low-dimensional quantum spin systems. While the existence of spinons has been demonstrated through scattering spectroscopy in ensemble samples, real-space imaging of these quasiparticles within individual spin chains has remained elusive. In this study, we construct individual Heisenberg antiferromagnetic spin-1/2 chains using open-shell [2]triangulene molecules as building blocks.

Prevalence and level of stress among final-year students at a health science institute in Bangladesh.

Background: Final-year students studying in various health science institutes are usually very stressed about their studies so that they can complete their studies without any hurdles. This stress can lead to poor academic and professional results because psychological issues such as anxiety and depression are frequently overlooked and not treated. This study aimed to measure the prevalence of stress and also assess the level of stress symptoms among the final year students of health science institute in Bangladesh.

Photopyroelectric tweezers for versatile manipulation.

Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical, biological, and medical fields. However, certain critical requirements, such as high-intensity laser beams, sophisticated electrode designs, additional electric sources, or low-conductive media, significantly impede their flexibility and adaptability, thus hindering their practical applications. Here, we report innovative photopyroelectric tweezers (PPT) that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability, enabling diverse manipulation in various working scenarios.

Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.

Concurrent inhibition of angiogenesis and immune checkpoints represents a potent therapeutic approach. We conducted a phase 2, multicenter, basket study to assess the efficacy and safety of combination therapy of famitinib (anti-angiogenic agent) plus camrelizumab (PD-1 antagonist) in patients with metastatic solid tumors across 11 cohorts (this study was registered at Clinicaltrials.gov [NCT04346381]).

Nano LiF-Enabled In Situ Synergistic Catalytic Polymeric Electrolytes for Stable Lithium Metal Batteries.

Solid polymer electrolytes (SPEs) with excellent ionic conductivity and a wide electrochemical stability window are critical for high-energy lithium metal batteries (LMBs). However, the widespread application of polymer electrolytes is severely limited by inadequate room-temperature ionic conductivity, sluggish interfacial charge transport, and uncontrolled reactions at the electrode/electrolyte interface. Herein, we present a uniform polymerized 1,3-dioxolane (PDOL) composite solid polymer electrolyte (PDOL-S/F-nano LiF CSE) that satisfies these requirements through the in situ catalytic polymerization effect of nano LiF on the polymerization of 1,3-dioxolane-based electrolytes.

Insight into enhanced tetracycline photodegradation by hematite/biochar composites: Roles of charge transfer, biochar-derived dissolved organic matter and persistent free radicals.

The combination of hematite and biochar significantly accelerated tetracycline (TC) removal under visible light irradiation. The k of TC removal with Hem/BC-5 reached 0.103 min, 3.

Probing Impact of Support Pore Diameter on Three-phase Interfaces of Pt/C Catalysts by Molecular Dynamic Simulation.

Investigating how the size of carbon support pores influences the three-phase interface of platinum (Pt) particles in fuel cells is essential for enhancing catalyst utilization. This study employed molecular dynamics simulations and density functional theory calculation to examine the effects of mesoporous carbon support size, specifically its pore diameter, on Nafion ionomer distribution, as well as on proton and gas/liquid transport channels, and the utilization of Pt active sites. The findings show that when Pt particles are located within the pores of carbon support (Pt/PC), there is a significant enhancement in the spatial distribution of Nafion ionomer, along with a reduction in encapsulation around the Pt particles, compared to when Pt particles are positioned on the surface or in excessively large pores of the carbon support.

Preparation of pH-Responsive Oil-in-Water Microemulsion Using a Full-Bio-Based Surfactant Containing a Dynamic Covalent Bond.

A novel pH-responsive full-bio-based surfactant (Ca-S) containing a dynamic covalent bond is synthesized using renewable cashew phenol, 5-chloro-2-furanaldehyde, and taurine. The structure of Ca-S is characterized by Fourier transform infrared spectroscopy (FTIR) and H nuclear magnetic resonance (NMR) analysis. Limonene containing oil-in-water (O/W) microemulsions are prepared on the basis of the Ca-S surfactant and are applied to the remediation of oil-contaminated soil under low-energy conditions at ambient temperature.

Synergistic Effect of Boron Doping and Porous Structures on Titanium Dioxide for Efficient Photocatalytic Nitrate Reduction to Nitrogen in Pure Water.

Photocatalytic reduction of nitrate to N holds great significance for environmental governance. However, the selectivity of nitrate reduction to N is influenced by sacrificial agents and the kinds of cocatalysts (such as Pt and Ag). The presence of unconsumed sacrificial agents can aggravate environmental pollution, while noble metal-based cocatalysts increase application costs.

CircPRKD3-loaded exosomes concomitantly elicit tumor growth inhibition and glioblastoma microenvironment remodeling via inhibiting STAT3 signaling.

Background: Glioblastoma stem cells (GSCs) and their exosomes (exos) are involved in shaping the immune microenvironment, which is important for tumor invasion and recurrence. However, studies involving GSC-derived exosomal circular RNAs (GDE-circRNAs) in regulating tumor microenvironment (TME) remain unknown. Here, we comprehensively evaluated the significance of a novel immune-related GDE-circRNA in glioma microenvironment.

Effects of EGR Rate and Temperature on Combustion and Emissions Characteristics of Compression Ignition Engines Fueled with Hydrotreated Vegetable Oil.

This study investigates the effects of varying exhaust gas recirculation (EGR) rates and temperatures on the combustion and emissions characteristics of a compression ignition engine fueled with hydrotreated vegetable oil (HVO). Understanding these effects is essential for optimizing renewable fuel applications in compression ignition engines, contributing to cleaner combustion, and supporting sustainable transportation initiatives. The experiments revealed that increasing the EGR rate to 20% not only reduces NOx emissions by approximately 25% but also increases smoke by around 15%, highlighting a trade-off between NOx and particulate matter control.

Predictive Laboratory Markers for Gastrointestinal Complications in Children with Henoch-Schönlein Purpura.

Background: Henoch-Schönlein Purpura (HSP) is a common systemic vasculitis in children that often involves the gastrointestinal system (GIS). Identifying reliable predictive markers for GIS complications is crucial for early intervention and improved patient outcomes.

Objective: This study aims to identify laboratory markers predictive of GIS complications in children with HSP using a machine learning approach.

An Integrating Microfluidic System for Concentration Gradient Generation of Exosomes and Exosome-Assisted Single-Cell-Derived Tumor-Sphere Formation.

To enhance exploration on tumor stem-like cells (TSCs) without altering their cellular biological characteristics, researchers advocate for application of single-cell-derived tumor-spheres (STSs). TSCs are regulated by their surrounding microenvironment, making it crucial to simulate a tumor microenvironment to facilitate STS formation. Recently, exosomes that originated from the tumor microenvironment have emerged as a promising approach for mimicking the tumor microenvironment.

A non-derivatized high-performance liquid chromatography method for simultaneous quantification of hydroxyl acids and amino acids in ammonolysis reactions.

A non-derivatized high-performance liquid chromatographic (HPLC) method was developed for the simultaneous quantification of hydroxyl acids and their amination products in ammonolysis reaction mixtures. By optimizing the mobile phase composition and pH (0.04 M KHPO-5% methanol, pH = 2.

Efficient Spermidine Production Using a Multi-Enzyme Cascade System Utilizing Methionine Adenosyltransferase from Lactobacillus fermentum with Reduced Product Inhibition and Acidic pH Preference.

Methionine adenosyltransferases (MATs; EC 2.5.1.

High-affinity VNARs targeting human hemoglobin: Screening, stability and binding analysis.

Hemoglobin, composed of α- and β-chains, is essential for oxygen transport and is key in diagnosing and treating gastrointestinal and blood disorders. It also aids in detecting blood contamination and estimating transfusion volumes. Immunological methods, based on antigen-antibody interactions, are distinguished by their high sensitivity and accuracy.