Impact of dairy cow personality traits on response to extended milking intervals and removal of supplemental concentrate in a free-traffic automated milking system.

Provision of supplemental concentrate in an automated milking system (AMS) is commonly used to encourage voluntary attendance, however, the motivation to voluntarily milk is highly variable between cows. The objectives of this study were to determine if dairy cow personality is associated with: 1) their short-term response to changes in factors believed to motivate voluntary AMS visits such as udder pressure and provision of supplemental feed (modulated by longer milking intervals or removal of AMS concentrate, respectively); and 2) their milking activity, production, and feeding behavior after returning to pre-treatment AMS milking interval and concentrate feed settings (i.e.

Biological testing unification for hemodialysis membranes evaluation: A step towards standardization.

Current hemodialysis treatments can cause adverse effects, many of which are linked to the membranes used in the process. These issues are being addressed through new materials and technologies, making it urgent to establish minimum guidelines for evaluating such membranes. This review proposes standardizing the biological tests and variables to evaluate the performance of new membranes, aiming to replicate hemodialysis conditions closely.

Chronic Radium-226 toxicity to and oxidative stress in the aquatic invertebrate .

The mining industry, including uranium mining and milling, is of high importance in Canada. It is, however, important to consider that ore processing can result in the creation of by-products that contain radionuclides such as radium-226 (Ra). Even with the strict discharge regulations in place, there is limited evidence to suggest that the current Canadian regulatory thresholds for Ra are protective for aquatic life.

Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.

The Canadian Stroke Best Practice Recommendations (CSPR) 7th edition includes this new module on the diagnosis and management of vascular cognitive impairment (VCI) with or without neurodegenerative disease. An expert writing group and people with VCI lived experience (PWLE) reviewed current evidence. Existing recommendations were reviewed and revised, and new recommendations added.

Assessment of the Quality of Root Canal Fillings-An Ex-Vivo Comparison of CBCT Scans, Conventional Intraoral Sensors, and a Novel Photon-Counting Sensor.

Objectives: To compare a novel photon-counting sensor, two CBCT protocols and two CMOS sensors on the detection of gaps between a gutta-percha cone and root canal walls.

Methods: Twenty-five mandibular incisors were prepared to 45/.04 (size/taper) at working length.

Stroke survivors with limited walking ability have unique barriers and facilitators to physical activity.

Purpose: Stroke is a leading cause of morbidity and mortality in Canada. Approximately 73% of stroke survivors experience limited walking ability, requiring a gait aid or assistance. Physical activity is important for secondary stroke prevention, in addition to its benefits for physical and mental health.

A collaborative interdisciplinary approach for trigger finger management.

Background: Stenosing tenosynovitis, or trigger finger, is a common cause of hand disability. This study outlines a trigger finger management protocol that redirects referrals for surgical consultations to conservative management first.

Purpose: The primary outcome variable was the protocol endpoint based on the resolution of trigger finger symptoms (i.

Endothelial cell (EC)-specific CTGF/CCN2 Expression Increases EC Reprogramming and Atherosclerosis.

Arterial endothelial cells (ECs) reside in a complex biomechanical environment. ECs sense and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of disturbed flow and commonly found at arterial bifurcations and around atherosclerotic plaques.

Detailed analysis of air pollution in the Canadian prairie region: A step toward net-zero emission.

Industrial, agricultural, and natural pollution pose a critical problem for the Prairie provinces of Canada, with significant environmental and health concerns. This study addresses a critical knowledge gap by assessing the cumulative impacts of pollutants in the Prairie region, which hosts 40 % of the Canada's indigenous population, often living near these pollution sources. By innovatively integrating Sentinel-5P satellite data, Google Earth Engine, ArcGIS, and Python, we show the trends in CO, NO₂, HCHO, SO₂, and aerosols from 2019 to 2023 at high resolution for the entire region, which sheds new light on the dynamics that operate beyond conventional air quality monitoring.

Towards the photodeposition of SiGe-type materials oligomers of cyclogermapentenes and cyclosilapentenes.

This article provides an alternative pathway towards cyclosilapentenes (, SiH2-iPr and SpiroSi) involving the use of Rieke magnesium to activate the requisite dienes for synthesis. Subsequent metal-mediated dehydrocoupling of cyclosilapentene and mixtures with another cyclogermapentene gives oligomers with backbone Si-Si (number average molecular weight, = 1.0 kDa) and Si-Ge ( = 1.

Macrolide resistance due to (55).

Unlabelled: Antimicrobial resistance (AMR) is a global threat. The identification and characterization of novel resistance genes is integral to AMR surveillance. The (55) gene was originally identified through whole genome sequencing of macrolide-resistant strains of .

Prevalence of posttraumatic stress disorder (PTSD) in Canada during the COVID-19 pandemic: results from the Survey on COVID-19 and Mental Health.

Introduction: This study provides a descriptive overview of the prevalence of posttraumatic stress disorder (PTSD) in Canada, across sociodemographic characteristics, mental health-related variables and negative impacts of the COVID-19 pandemic.

Methods: Data were obtained from cycles 1 and 2 of the Survey on COVID-19 and Mental Health (SCMH), collected in fall 2020 (N = 14 689) and spring 2021 (N = 8032). The prevalence of PTSD was measured using the PTSD Checklist for DSM-5 (PCL-5) Cross-sectional associations were quantified using logistic regression, while controlling for sociodemographic characteristics.

Metal Mobilization from Thawing Permafrost Is an Emergent Risk to Water Resources.

Metals are ubiquitous in Earth's Critical Zone and play key roles in ecosystem function, human health, and water security. They are essential nutrients at low concentrations, yet some metals are toxic at a high dose. Permafrost thaw substantially alters all the physical and chemical processes governing metal mobility, including water movement and solute transport and (bio)geochemical interactions involving water, organic matter, minerals, and microbes.

How adverse childhood experiences impact the professional quality of life of residential care workers: resilience as a mediator for burnout, secondary traumatic stress, and compassion satisfaction.

Introduction: The well-being of trauma-affected children and youth in residential care settings is contingent upon the well-being of the workers who care for them, who are increasingly expected to provide care in a trauma-informed manner. The well-being of residential care workers (RCWs) may be impacted by their own histories of adversity, their capacity individually and collectively to navigate to resources that sustain their well-being (resilience), and current perceptions of their professional quality of life.

Objective: This study aimed to fill a research gap by canvassing the perspectives of RCWs to determine what and how they need to be supported in their work.

Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study.

Cannabinoid receptor 1 (CB1R) has been extensively studied as a potential therapeutic target for various conditions, including pain management, obesity, emesis, and metabolic syndrome. Unlike orthosteric agonists such as Δ-tetrahydrocannabinol (THC), cannabidiol (CBD) has been identified as a negative allosteric modulator (NAM) of CB1R, among its other pharmacological targets. Previous computational and structural studies have proposed various binding sites for CB1R NAMs.

Z-residual diagnostic tool for assessing covariate functional form in shared frailty models.

Survival analysis often involves modeling hazard functions while considering frailty to account for unobserved cluster-level factors in clustered survival data. Shared frailty models have gained popularity for this purpose, but assessing covariate functional form in these models presents unique challenges. Martingale and deviance residuals are commonly used for visually assessing covariate functional form against continuous covariates.

Parental experiences of caring for their preschool children after declining vaccines: a qualitative systematic review.

Objective: This review synthesizes qualitative research about the experiences of parental caregivers enhancing their children's health after making the decision to not vaccinate their preschool children. This review aims to help health care providers understand the parental work involved in caring for under-vaccinated or unvaccinated children.

Introduction: Much of the current qualitative research literature about parents who are vaccine-hesitant or who decide not to vaccinate their children focuses on parental perceptions about the safety and efficacy of vaccines and decision-making.

Visible and invisible cultural patterns influencing women's use of maternal health services among Igala women in Nigeria: a focused ethnographic study.

Background: Explicit and implicit cultural patterns are critical cultural norms, beliefs, and practices that determine women's health-seeking behaviour. These cultural patterns could limit women's use of maternal health services, resulting in maternal health complications. The study aims to provide an in-depth understanding of explicit and implicit cultural patterns, their meanings and how they influence women's use of maternal health services among Igala women in Nigeria.

High throughput method for simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotective agents.

Cryoprotective agent (CPA) toxicity is the most limiting factor impeding cryopreservation of critically needed tissues and organs for transplantation and medical research. This limitation is in part due to the challenge of rapidly screening compounds to identify candidate molecules that are highly membrane permeable and non-toxic at high concentrations. Such a combination would facilitate rapid CPA permeation throughout the sample, enabling ice-free cryopreservation with minimal toxicity.

Addressing Water Scarcity to Achieve Climate Resilience and Human Health.

Water scarcity is projected to affect half of the world's population, gradually exacerbated by climate change. This article elaborates from a panel discussion at the 2023 United Nations Water Conference on Addressing Water Scarcity to Achieve Climate Resilience and Human Health. Understanding and addressing water scarcity goes beyond hydrological water balances to also include societal and economic measures.

Case report: Diagnostic challenges of papulonodular mucinosis in a 67-year-old female.

Papulonodular mucinosis is a rare dermatological condition characterized by mucin deposition in the dermis, leading to the formation of papules and nodules that can occur with, or antedate, autoimmune connective tissue diseases. This case report presents a 67-year-old female with a chronic history of cutaneous mucinosis, which posed significant diagnostic challenges. Despite various treatments and extensive diagnostic workup, her condition evolved, highlighting the difficulties in diagnosing papulonodular mucinosis, especially in the absence of systemic lupus erythematosus and antinuclear antibody positivity.