AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis.

The inflammasome AIM2 regulates multiple aspects of innate immune functions and serves as a critical mediator of inflammatory responses. AIM2 inflammasome activation leads to the production of pro-inflammatory cytokines, IL-1β and IL-18 and participates triggering a pyroptosis response needed to counteract excessive cell proliferation. In addition, AIM2 expression and activation is wide regulated since alteration in its activity may derived in pathological consequences.

Noninvasive Glucose Measurements Through Transcutaneous Raman Spectroscopy: A Review.

Background: People living with diabetes need constant glucose monitoring to avoid health complications. However, they do not monitor their glucose levels as often as recommended, probably because glucose measurement devices can be painful, costly, need testing strips or sensors, require lancing the finger or inserting a sensor with risk of infection, and can be inaccurate or have failures. Therefore, developing new alternatives for noninvasive glucose measurements that overcome these disadvantages is necessary, being Raman spectroscopy (RS) a solution.

CAD/CAM lithium disilicate ceramic crowns: Effect of occlusal thickness on fracture resistance and fractographic analysis.

This study uses fracture tests and fractographical analysis to compare computer-aided design and computer-aided manufacturing (CAD/CAM) lithium disilicate molar crowns with the previous occlusal thickness recommendation of 1.5-mm, the new recommendation of 1.0-mm, and a less invasive thickness of 0.

Bromatological Analysis and Characterization of Phenolics in Snow Mountain Garlic.

The remarkable properties of garlic L. have been described, but little is known about Snow mountain garlic. Understanding general aspects of this garlic composition, including the presence of phenolics, will establish its possible use for health or infer which compounds can contribute to improving it.

Treatment of ectopic eruption of the maxillary first permanent molar in children and adolescents: A scoping review.

Aim: Ectopic eruption of the first permanent molar (EFUPM) is defined as its local disturbed eruptive behaviour, positioning too mesially against the distal aspect of the second upper primary molar during the developing mixed dentition. The EFUPM prevalence is up to 6% and affects both genders equally. The present study aimed to perform a scoping review to collect the most relevant studies published in the last 30 years and focused on the different strategies, traditional and novel, for treating irreversible uni- or bilateral EFUPM in children.

Evaluation of a biocoagulant from devilfish invasive species for the removal of contaminants in ceramic industry wastewater.

This study evaluated the effectiveness of a biocoagulant produced from the devilfish invasive species and its combination with two chemical coagulants (aluminum sulfate and ferric sulfate) to remove turbidity, chemical oxygen demand, and total suspended solids in ceramic industry wastewater using a combined experimental design of Mixture-Process. This design optimized the coagulation process and evaluated the effects and interactions between mixture components and coagulant doses. An analysis of variance was used to analyze the experimental data obtained in the study, and the response surface plots by response type (turbidity, chemical oxygen demand, and total suspended solids) were obtained.

Complex effects on Ca2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder.

P/Q-type Ca currents mediated by Ca2.1 channels are essential for active neurotransmitter release at neuromuscular junctions and many central synapses. Mutations in CACNA1A, the gene encoding the principal Ca2.

Effect of breed and management practices on reproductive and milking performance of rangeland goats.

The traditional goat production systems on arid and semi-arid rangelands of northern Mexico are characterized by minimum external inputs; therefore, little is known about goat response to technological improvements. This observational study aimed to ascertain the effect of using improved goat production technologies and breed on milk yield and reproductive performance of goats on rangeland. The study was conducted from January 2017 to June 2018.

3D-Printed Tubular Scaffolds Decorated with Air-Jet-Spun Fibers for Bone Tissue Applications.

The fabrication of instructive materials to engineer bone substitute scaffolds is still a relevant challenge. Current advances in additive manufacturing techniques make possible the fabrication of 3D scaffolds with even more controlled architecture at micro- and submicrometric levels, satisfying the relevant biological and mechanical requirements for tissue engineering. In this view, integrated use of additive manufacturing techniques is proposed, by combining 3D printing and air-jet spinning techniques, to optimize the fabrication of PLA tubes with nanostructured fibrous coatings for long bone defects.

The role of arylamine N-acetyltransferases in chronic degenerative diseases: Their possible function in the immune system.

Since their discovery, arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2, respectively) have been associated with the metabolism of xenobiotics. NAT2 is the main factor in the therapeutic success of tuberculosis treatment due to its role in the biotransformation of isoniazid. However, researchers have started to investigate the possible participation of NAT1 and NAT2 (NATs) in carcinogenesis, although the mechanisms have not been elucidated fully.

A simple quantitative method using TLC-image analysis to determine fructooligosaccharides (FOS) in food samples.

The thin-layer chromatography technique (TLC) is a simple and inexpensive analysis commonly used to identify qualitatively the presence of carbohydrates in food samples such as mono- di and oligosaccharides particularly. TLC assay could be improved using image processing software for the semiquantitative determination of this type of compound. In the present work, TLC-image analysis with Silica Gel 60 TLC plates was used for the semiquantitative determination of 6 standards of carbohydrates (glucose, fructose, sucrose, 1-kestose, nystose, and fructofuranosylnystose).

Sodium Selenite Diminished the Regulatory T Cell Differentiation In Vitro.

Sodium selenite modulates the activity of lymphocytes. It negatively regulates the suppressive activity of cells and increases the immune response. In this study, we evaluated whether the regulatory T cell differentiation was modulated by sodium selenite.

In Vitro Inhibitory and Proliferative Cellular Effects of Different Extracts of : A Preliminary Study.

, a hemiparasitic plant known as "seca palo," is used by Nahuatl traditional healers against diabetes, wounds, and rashes. We aimed to investigate the effects of different extracts, which were selected based on their traditional use in Tamazunchale, San Luis Potosí, on the cell viability and antioxidant activity in HeLa cell cultures. growing on and sp.

End-of-life management of single-use baby diapers: Analysis of technical, health and environment aspects.

Single-use baby diapers belongs to an important group of products used in the parenting journey because of their high performance and convenience. Single-use baby diapers are normally thrown away after one-time use, resulting in a waste management problem. The goal of this paper was to better understand main environmental concerns of different types of diapers and address how to reduce them, with a special consideration of waste management strategies and user behaviour practices.

Multiband Spectrum Sensing Based on the Sample Entropy.

Cognitive radios represent a real alternative to the scarcity of the radio spectrum. One of the primary tasks of these radios is the detection of possible gaps in a given bandwidth used by licensed users (called also primary users). This task, called spectrum sensing, requires high precision in determining these gaps, maximizing the probability of detection.

Operative results of AO A3 and A4 traumatic injuries in the thoracic and lumbar spine. A multicenter surveillance study of 4230 patients from the German Spine Registry (DWG-Register).

Background: The diagnosis, classification and treatment of thoracolumbar burst fractures, continue to be controversial. Surgery is generally the preferred treatment for unstable fractures while stable fractures are managed conservatively. This study aims to describe surgical procedures, outcomes, complications, demography, clinical features and differences between A3 and A4 fractures (AO classification) of the thoracolumbar region.

Antinociceptive effects of Laelia anceps Lindl. and Cyrtopodium macrobulbon (Lex.) G.A. Romero & Carnevali, and comparative evaluation of their metabolomic profiles.

Ethnopharmacological Relevance: Laelia anceps and Cyrtopodium macrobulbon are two orchids used in Mexican traditional medicine for treating pain.

Aim Of The Study: The individual antinociceptive activity of ethanol extracts from the roots of Laelia anceps (LAE) and Cyrtopodium macrobulbon (CME) was evaluated, and their metabolomic profiles were comparatively evaluated. The antinociceptive activity of CME and naproxen combination (1:1) was also addressed.

Waterborne Antifouling Paints Containing Nanometric Copper and Silver against Marine Species.

Due to the concern to find an alternative to reduce the colonization (microfouling and macrofouling) or the biocorrosion of surfaces submerged for long periods in water, we evaluated the antifouling activity of a commercial paint added with silver nanoparticles (AgNP's) and copper nanoparticles (CuNP's), beside copper-soybean chelate, by electrolytic synthesis, using them in low concentrations (6.94 - 04 mg Ag g paint, 9.07 - 03 mg Cu g paint, and 1.

Simultaneous determination of four serotonin selective reuptake inhibitors by an UPLC MS-MS method with clinical application in therapeutic drug monitoring.

An analytical method of ultra-high performance liquid chromatography coupled to tandem mass spectrometry detection was developed and validated for the simultaneous quantification in plasma of four selective serotonin reuptake inhibitor antidepressants: sertraline, escitalopram, paroxetine, fluoxetine, and its metabolite norfluoxetine. A simple protein precipitation was performed with acetonitrile containing 100 ng/mL of indomethacin, which was used as internal standard. Chromatographic separation was carried out on an Acquity BEH C18 column with isocratic elution of the mobile phase consisting of 5 mmol/L ammonium acetate with 0.

Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells.

Doxazosin and carvedilol have been evaluated as an alternative treatment against chronic liver lesions and for their possible role during the regeneration of damage caused by liver fibrosis in a hamster model. However, these drugs have been reported to induce morphological changes in hepatocytes, affecting the recovery of liver parenchyma. The effects of these /𝛽 adrenoblockers on the viability of hepatocytes are unknown.

Nanosorbents as Materials for Extraction Processes of Environmental Contaminants and Others.

The aim of this work focuses on the application of nanomaterials (NMs) in different sorptive extraction techniques for the analysis of organic contaminants from environmental samples of distinct matrix compositions. Without any doubt, the integration of specific NMs such as carbonaceous nanomaterials, magnetic nanoparticles (MNPs), metal-organic frameworks (MOFs), silica nanoparticles, and ion-imprinted NPs with solid-phase extraction techniques counting -SPE, solid-phase microextraction (SPME), and stir bar sorptive extraction (SBSE) impact on the improvements in analytical performance. The application of NMs as sorbents in the extraction of organic pollutants in environmental samples allows for providing better sensitivity, repeatability, reproducibility, and reusability.

Study of Molybdenite Floatability: Effect of Clays and Seawater.

Current challenges in froth flotation are the presence of complex gangues and the use of low-quality waters, such as seawater. In this scenario, the recovery of molybdenum minerals is difficult, mainly due to the hydrophobic faces' physicochemical changes. In the present study, the natural floatability of pure molybdenite was analyzed by using microflotation assays, and hydrophobicity was measured by performing contact-angle measurements.

Effects of drug abuse and mental disorders on oral health: A case report.

Substance use disorders, related to mental health issues can lead to oral pathologies. The purpose of this case report was to identify the oral conditions and manifestations in a 28-year-old male narco-dependent schizophrenic who smoked tobacco and marijuana. In intra-oral clinical exploration, poor oral hygiene, excessive tartar formation and dental plaque were observed, and the diagnosis of severe chronic periodontitis was established.