A Newly Synthesized Benzimidazolium Salt: 1-(2-Cyanobenzyl)-3-(4-Vinylbenzyl)-1H-Benzo[D]imidazol-3-ium Chloride as a Potential Anticancer Agent for Colon Cancer Treatment, In Vitro Study.

Colon cancer is one of the most common cancer-related deaths. Drug resistance is one of the biggest challenges in cancer treatment. Numerous pharmacological and biochemical investigations have documented the benzimidazole ring's anticancer, anti-inflammatory, and antioxidant properties.

Turkish adapration of "Simulation-Based interprofessional Teamwork Assessment Tool": SITAT-TR.

Inroduction: The Simulation-based Interprofessional Teamwork Assessment Tool (SITAT) is a valuable instrument for evaluating individual performance within interprofessional teams.

Aim: This study aimed to translate and validate the SITAT into Turkish (SITAT-TR) to enhance interprofessional education and teamwork assessments in the Turkish context.

Methods: This study was designed as an adaptation study in a descriptive research design.

Strongyloides stercoralis infection in a patient initiating corticosteroid therapy for hypereosinophilia: A case report.

Strongyloides stercoralis (S. stercoralis) is a soil-transmitted nematode that is endemic to tropical and subtropical regions. S.

[Multicentric Screening of Local Antibiotic Resistance in Uncomplicated Urinary System Infections: 1850 Patients from 37 Centers].

This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data.

Fractal analysis of jawbone structure in patients with rheumatoid arthritis.

Purpose: Periarticular and generalized osteoporosis are well-known comorbidities of rheumatoid arthritis (RA), associated with either the disease itself or glucocorticoid therapy. This study was performed to quantitatively evaluate changes in the jawbones of patients with RA using fractal analysis (FA).

Materials And Methods: The study comprised 186 participants, including 144 women and 42 men.

Investigation of the antibacterial activity of L. and its anti-QS potential on PAO1.

The study aims to evaluate the Quorum Sensing (QS) system inhibition against some Gram-positive and Gram-negative bacteria detected by molecular modeling of R. cathartica L. plant extract.

Broccoli () leaves exhibit significant antidiabetic potential in alloxan-induced diabetic rats: the putative role of ABC vacuolar transporter for accumulation of Quercetin and Kaempferol.

Background: The global prevalence of diabetes among adults over 18 years of age is expected to increase from 10.5% to 12.2% (between 2021 and 2045).

Miniscrew-assisted Rapid Palatal Expansion Before Orthognathic Surgery for a Patient With Laterognathia.

In this case report, a 19-year-old male patient with maxillary transverse deficiency, concave profile, and facial asymmetry is presented. In the case of transversal insufficiency, nonsurgical maxillary expansion was performed with the miniscrew-assisted rapid palatal expansion (MARPE) appliance to reduce the number of surgeries and provide both dentoalveolar and skeletal expansion. The periodontal soundness and short-term stability of the maxillary expansion were confirmed both clinically and radiologically.

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

Evaluation of angiotensin converting enzyme insertion/deletion, alpha adducin (ADD1) G460W, and IL-10 gene polymorphisms, and determination of prognostic effects in idiopathic sudden sensorineural hearing loss.

Objective: The aim of this study was to examine angiotensin converting enzyme (ACE) insertion/deletion, alpha adducin, and interleukin-10 (IL-10) gene polymorphisms (GPs) in terms of both idiopathic sudden sensorineural hearing loss (ISSNHL) risk and their potential prognostic effects.

Methods: The study group consisted of 70 patients and the control group consisted of 50 patients. Venous blood samples were analyzed for relevant GPs via kompetitive allele-specific polymerase chain reaction.

Development of Lacosamide-loaded In-Situ Gels through Experimental Design for Evaluation of Ocular Irritation In Vitro and In Vivo.

Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl D-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli.

Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia.

The constituents of the aqueous, ethanol, hexane, and methanol extracts of Anatolian propolis collected from the Eastern Black Sea Region (Çayeli-Rize) were investigated by GC-MS, HPLC and AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic acid, rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin and gallic acid were determined.

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism.

The Parkinson's disease (PD)-linked protein Leucine-Rich Repeat Kinase 2 (LRRK2) consists of seven domains, including a kinase and a Roc G domain. Despite the availability of several high-resolution structures, the dynamic regulation of its unique intramolecular domain stack is nevertheless still not well understood. By in-depth biochemical analysis, assessing the Michaelis-Menten kinetics of the Roc G domain, we have confirmed that LRRK2 has, similar to other Roco protein family members, a K value of LRRK2 that lies within the range of the physiological GTP concentrations within the cell.

Validity and reliability study of the Turkish version of KOOS-ACL questionnaire.

Background: This study aimed to adapt the Knee injury and Osteoarthritis Outcome Score- Anterior Cruciate Ligament (KOOS-ACL) into Turkish and to assess its validity and reliability.

Methods: The adaptation process involved translation, back-translation, and cultural adaptation of the questionnaire. Totally 133 patients who had a diagnosis of anterior cruciate ligament tear was recruited.

Efficacy of Preoperative Pericapsular Nerve Group Block in Patients with Hip Fracture and its Effect on the Success of Spinal Anaesthesia: A Retrospective Study.

Objective: We intended to research the efficacy of pericapsular nerve group (PENG) block performed with preoperative ultrasonography (USG) in patients who underwent hip fracture repair under spinal anaesthesia and whether it affects the success of spinal anaesthesia.

Methods: The files of 100 patients were analysed, and 60 patients were enrolled in the study. The patients were assigned into two groups: Group P (n = 30) consisted of patients who underwent USG-guided PENG block before the start of surgery and the control group (Group C; n = 30) consisted of patients in whom tramadol infusion was initiated.

Neuroimaging assessment of basal ganglia volumes in Tourette Syndrome: a systematic review and meta-analysis.

Introduction: An increasing number of studies indicate that anatomical, physiological, and histological differences in the basal ganglia(BG) lie in the etiology of Tourette Syndrome(TS). However, the fact that there are very few studies on the anatomy of the BG in TS, small sample sizes, and unclear information as a consequence of these studies' contradictory findings is a significant gap in the scientific literature. The current systematic review and meta-analysis were performed to examine the differences in BG volumes between TS and controls.

The effect of intraperitoneal LR-PRP on bacterial translocation in an experimental model of peritonitis in rats.

Background: This study aims to examine the effect of Leukocyte-Rich Platelet-Rich Plasma (LR-PRP) on bacterial translocation in an experimental peritonitis model in rats. Secondary peritonitis occurs due to the loss of integrity in the mucosal barrier of the gastrointestinal system, resulting from contamination of the peritoneal cavity by microorganisms. LR-PRP has been shown to have positive anti-infectious, immunomodulatory, and angiogenetic effects.

Profiling of Toll-like Receptors and Related Signaling Mediators in the Pathogenesis of Morphea.

Introduction: Morphea, also known as localized scleroderma, is a rare fibrosing inflammatory disease of unknown pathogenesis.

Objectives: Although the genetic basis for morphea is important, reports on the evaluation of Toll-like receptors (TLR) in this disease is quite limited. We aimed to evaluate TLR expression levels and serum IL-6, IL-17A, TGF-β1, FGF, and VEGF levels in patients with morphea and compare these results with healthy controls.

Septic Arthritis of the Temporomandibular Joint in a Geriatric Patient: A Case Report.

Septic arthritis of the temporomandibular joint is a rare pathology. There is no consensus in the literature regarding etiopathogenesis and treatment. Pain, swelling, trismus, and mandibular deviation are common.

Production and characterization of encapsulated Thymoquinone loaded bacterial cellulose/chitosan composite nano film and investigation of its in vitro antibacterial activity.

In this study, nanostructured thin films were produced from thymoquinone (TQ)-loaded composites encapsulated with different ratios of bacterial nanocellulose (BNC) to chitosan (CS). The study aimed to investigate their characterization, antibacterial effects, and potential as drug film coating materials. Chemical features and morphological characteristics were determined, and release tests and antibacterial assays were conducted on the thin film layers.

Multidisciplinary Approach to Smile Design of a Patient With Osteogenesis Imperfecta With Clear Aligners and Prosthetic Restorations.

Osteogenesis imperfecta (OI) is an autosomal dominant disease that affects the teeth and the musculoskeletal system. Orthodontic treatment in OI patients may be risky due to the fragility of dental hard tissues. Clear aligners may be considered a suitable orthodontic treatment method for these patients.

Evaluation of MENAQUINONE-7 and fat-soluble vitamin production by starter cultures during fermentation in dairy products using RPLC method.

Vitamin K2, also known as menaquinone, has become a significant research focus, particularly in fermented products. This study aims to investigate the content of menaquinone-7 (MK-7), an essential form of vitamin K, and other fat-soluble vitamins (A, D, E) during the fermentation of various fermented milk products. The vitamin contents of six fermented milk products were analyzed: two yogurt samples (produced with commercial starter and probiotic starter), two kefir samples (produced with commercial starter and kefir grain), and milk fermented with or .

Enhanced Cycling Stability of Al-Doped LiMn Al NiCoO as a Cathode Material for Li-Ion Batteries by a Supercritical-CO-Assisted Method.

Lithium-rich layered oxide materials (Li-NMC) are considered a potential cathode material for next-generation batteries, thanks to their high theoretical specific capacity. Large potential drop and capacity loss after long cycles are the main obstacles to expanding commercial utilization of Li-NMC. In the past decade, great efforts have been made to overcome those issues of Li-NMCs.