2 results match your criteria: "University of Rochester School of Medicine and the Mary M. Gooley Hemophilia Center[Affiliation]"
Regulation and importance of factor VIII levels in hemophilia A carriers.
Curr Opin Hematol
September 2021
University of Rochester School of Medicine and the Mary M. Gooley Hemophilia Center at Rochester General Hospital, Rochester, New York, USA.
Purpose Of Review: To summarize the recent literature related to female hemophilia A carriers with respect to prevalence in the population, the impact of baseline factor VIII levels and other influences on bleeding phenotype, and clinical management needs.
Recent Findings: Many female hemophilia A carriers are at risk for abnormal bleeding, yet they are underrecognized by healthcare providers and their bleeding symptoms are underreported. Low FVIII levels are consistently associated with clinically significant bleeding and correlate well with skewed X chromosome inactivation (XCI).
Article Synopsis
- Reproductive tract bleeding (RTB) can complicate anticoagulant therapy in menstruating females, but little is known about how it's diagnosed and managed in adolescents and young adults.
- A survey conducted with healthcare professionals revealed that menstrual history is rarely reviewed before starting anticoagulants, and there are varying management strategies when RTB occurs, with the choice of treatment influenced by the timing of complications.
- The findings stress the importance of reviewing menstrual history and suggest the need for more research to establish effective anticoagulant options for young females experiencing RTB.