Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies.

The utilization of targeted nanoparticles as a selective drug delivery system is a powerful tool to increase the amount of active substance reaching the target site. This can increase therapeutic efficacy while reducing adverse drug effects. However, nanoparticles face several challenges: upon injection, the immediate adhesion of plasma proteins may mask targeting ligands, thereby diminishing the target cell selectivity.

Synthesis of bismuthanyl-substituted monomeric triel hydrides.

The syntheses and characterizations of the first bismuthanylborane monomers stabilized only by a donor in D·BHBi(SiMe) (D = DMAP 1a, IDipp 1b, IMe1c; DMAP = 4-dimethylaminopyridine, IDipp = 1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene, IMe = 1,3,4,5-tetramethylimidazol-2-ylidene) are presented. All compounds were synthesized by salt metathesis reactions between D·BHI and KBi(SiMe)(THF) and represent some of the extremely rare compounds featuring a 2c-2e B-Bi bond in a molecular compound. The products display high sensitivity towards air and light and slowly decompose in solution even at -80 °C.

Modulations of the work function and morphology of a single MoS nanotube by charge injection.

Both the miniaturization of transistor components and the ongoing investigation of material systems with potential for quantum information processing have significantly increased current interest of researchers in semiconducting inorganic nanotubes. Here we report on an additional outstanding aspect of these nanostructures, namely the intrinsic coupling of electronic and mechanical properties. We observe electronic and morphology changes in a single MoS nanotube, exposed to charge injections by means of an atomic-force-microscopy tip.

Light-induced homolysis of copper(ii)-complexes - a perspective for photocatalysis.

Over the past decade, photocatalysis has developed into a powerful strategy for the selective functionalization of molecules through radical intermediates. Besides the well-established iridium- or ruthenium-based photocatalysts, which ideally fulfill the requirements for a photocatalyst, such as long excited-state lifetimes and photostability, the shift towards earth-abundant metal-based photocatalysts has so far been less explored. The concept of light-induced homolysis (LIH) for generating radicals has recently gained significant interest as a new platform for inducing photoreactions with earth-abundant 3d-metal complexes despite only having excited-state lifetimes in the low nanosecond range or even below.

Synthesis of Chiral Tetrahydrofurans and Pyrrolidines by Visible-Light-Mediated Deoxygenation.

The synthesis of chiral tetrahydrofurans and pyrrolidines starting from 1,2-diols or β-amino alcohols, respectively, by visible-light-mediated deoxygenation is described. Easily accessible monoallylated/propargylated substrates were activated either as inexpensive ethyl oxalates or as recyclable 3,5-bis(trifluoromethyl)benzoates to generate alkyl radicals suitable for 5--/5-- cyclizations under visible-light irradiation.