Spiro thiochromene-oxindoles as novel anti-inflammatory agents: design, sustainable synthesis, and evaluations.

A one-pot, acid-, base-, and metal-free, multicomponent strategy has been developed to synthesize spiro thiochromene-oxindole derivatives as potential anti-inflammatory agents. The synthesized compounds were screened for their anti-inflammatory activity by inhibiting heat-induced Bovine Serum Albumin (BSA) denaturation assay, revealing moderate to good efficacy. Compounds 4e, 4k, and 4h exhibited the highest activity, inhibiting BSA denaturation by 90.

Optimization of Smoking Classification by Applying Neural Network with Variable Importance Using Cytokine Biomarkers.

Cigarette smoking is a preventable epidemic that is a leading cause of death. It increases the risk of coronary heart disease, stroke, lung cancer, chronic obstructive lung diseases etc., multifold.

Review on polyaniline-based nanocomposite heterogeneous catalysts for catalytic reduction of hazardous water pollutants.

Water contamination by highly toxic substances has generated serious ecological disturbances and health problems for humans. Hence, decontamination of toxic pollutants using advanced, inexpensive, and eco-friendly approaches is the current demand. Heterogeneous catalyst-based catalytic reduction processes have offered the opportunity to transform hazardous water pollutants into non-hazardous products sustainable, eco-friendly, and efficient routes and might be a competitive substitute for existing traditional water purification techniques.

Green design and synthesis of some novel thiazolidinone appended benzothiazole-triazole hybrids as antimicrobial agents.

The global increase in bacterial resistance poses a significant threat, jeopardizing the effectiveness of antibiotics. Therefore, the development of new and efficient antimicrobial agents is pre-dominant. Taking this into consideration, in the present study, we designed and reported the facile synthesis of two novel series benzothiazole-triazole and thiazolidinone-appended benzothiazole-triazole hybrids using a molecular hybridization approach in a one-pot process.

Surface functionalized silver-doped ZnO nanocatalyst: a sustainable cooperative catalytic, photocatalytic and antibacterial platform for waste treatment.

The different dyes used and discharged in industrial settings and microbial pathogenic issues have raised serious concerns about the content of bodies of water and the impact that dyes and microbes have on the environment and human health. Efficient treatment of contaminated water is thus a major challenge that is of great interest to researchers around the world. In the present work, we have fabricated functionalized silver-doped ZnO nanoparticles (Ag-doped ZnO NPs) a hydrothermal method for wastewater treatment.

Sustainable synthesis of biomass-derived carbon quantum dots and their catalytic application for the assessment of α,β-unsaturated compounds.

Herein, we demonstrate a simple, reproducible, and environment-friendly strategy for the synthesis of carbon quantum dots (CQDs) utilizing the mango () kernel as a renewable green carbon source. Various analytical tools characterized the as-prepared CQDs. These fluorescent CQDs showed significant water solubility with a uniform size of about 6 nm.

Women, work and pandemic: An impact study of COVID-19 lockdown on working women in India.

The first wave of the pandemic caused due to COVID-19 was marked by a complete lockdown in India in March 2020. This unprecedented time and global health crisis pushed everyone indoors and compelled all employees to work from home (WFH). This study is an attempt to explore the challenges and possibilities of the WFH scenario in the context of working women in India.

The graphite-catalyzed -functionalization of arylboronic acids in an aqueous medium: metal-free access to phenols, anilines, nitroarenes, and haloarenes.

An efficient, metal-free, and sustainable strategy has been described for the -functionalization of phenylboronic acids using air as an oxidant in an aqueous medium. A range of carbon materials has been tested as carbocatalysts. To our surprise, graphite was found to be the best catalyst in terms of the turnover frequency.

Site-specific role of bifunctional graphitic carbon nitride catalyst for the sustainable synthesis of 3,3-spirocyclic oxindoles in aqueous media.

Functionalized graphitic carbon nitride (Sg-CN) has been manufactured and used as a reusable catalyst for the one-pot production of various spiro-pyrano chromenes and spiro indole-3,1'-naphthalene tetracyclic systems in aqueous media. An ultrasound-assisted method has been used for the functionalization of g-CN. The catalytic functionalities and the structural integrity of the catalyst were characterized different analytical tools.

Multicomponent synthesis of dispiroheterocycles using a magnetically separable and reusable heterogeneous catalyst.

Dispiroheterocycles have been synthesized by pseudo-four component reaction of 6-aminouracil/6-amino-2-thiouracil/2-amino-1,3,4-thiadiazole, -toluidine and isatins in an ethanol-water mixture as solvent using β-cyclodextrin functionalized FeO nanoparticles as a magnetically separable and reusable heterogeneous catalyst. The nanocatalyst was synthesized and characterized by physicochemical characterization including Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD).

Catalytic effect on hydrogen de/absorption properties of MgH - x wt% MM (x = 0, 10, 20, 30) nanomaterials.

Reversible hydrogen storage in MgH under specified conditions is a possible way for the positive reception of hydrogen economy, in which the developments of cheap and highly efficient catalysts are the major challenge, still now. Herein, MgH - x wt% MM (x = 0, 10, 20, 30) nanomaterials are prepared via ball milling method and has been evaluated for the hydrogen storage performance, which are characterized by XRD, SEM and DTA/DSC. The hydrogen absorption properties of nanomaterials are measured by pressure composition isotherm, and analysis show that the MgH - 30 wt% MM nanomaterials have the maximum hydrogen absorption capacity (~ 3.

Microwave-assisted nanocatalysis: A CuO NPs/rGO composite as an efficient and recyclable catalyst for the Petasis-borono-Mannich reaction.

A CuO NP decorated reduced graphene oxide (CuO NPs/rGO) composite was synthesized and characterized using various analytical techniques XRD, TEM, SEM, UV-Vis, FT-IR, EDX, XPS and CV. The activity of the catalyst was probed for the Petasis-Borono-Mannich (PBM) reaction of boronic acids, salicylaldehydes, and amines under microwave irradiation (MW). The CuO NPs/rGO composite works as a catalyst as well as a susceptor and augments the overall ability of the reaction mixture to absorb MW.

Dendritic atrophy constricts functional maps in resonance and impedance properties of hippocampal model neurons.

A gradient in the density of hyperpolarization-activated cyclic-nucleotide gated (HCN) channels is necessary for the emergence of several functional maps within hippocampal pyramidal neurons. Here, we systematically analyzed the impact of dendritic atrophy on nine such functional maps, related to input resistance and local/transfer impedance properties, using conductance-based models of hippocampal pyramidal neurons. We introduced progressive dendritic atrophy in a CA1 pyramidal neuron reconstruction through a pruning algorithm, measured all functional maps in each pruned reconstruction, and arrived at functional forms for the dependence of underlying measurements on dendritic length.

Green Synthesis of AgNPs Stabilized with biowaste and their antimicrobial activities.

In the present study, rapid reduction and stabilization of Ag+ ions with different NaOH molar concentration (0.5 mM, 1.0 mM and 1.

An Antioxidant potential of Hingot and Hadjod.

The antioxidant activity of two plants - Hadjod i.e. Cissus quadrangularis (CQ) and Hingot i.

Txicological Aspects of Newly Designed Macrocyclic Complexes of Iron(II).

Brine shrimp lethality of a new series of 16 to 26-membered macrocycles of iron(II) containing tetraaza groups and prepared by the template condensation reaction of diacarboxylic acids (malonic, succinic, glutaric or adipic) with 2,6-diaminopyridine and diethylenetriamine in 1:2:2 molar ratios have been studied. Structures and bonding of the macrocyclic complexes have been proposed based on elemental analyses, IR, electronic, X-ray and mass spectral studies. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles.

Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II).

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats.

The antifertility activity of organoantimony(III) complexes PhSb[RC(NC(6)H(4)S)CH(2)(NC(6)H(4)S)CR'] {R' = CH(3) (R(1)) and R = R' = CF(3) (R(2))} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R(1) and R(2) at the dose level of 20 mg/kg. b.

Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II).

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N(4)mL] reacts with SnCl(2) and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N(4)mL)Cl(2)].

Toxicity, Spectroscopic Characterization and Electrochemical Behaviour of New Macrocclic Complexes of Lead(II) and Palladium(II) Metals.

Tetraazamacrocyclie complexes of lead and palladium have been synthesized by the template process using the bis(benzil)ethylenediamine precursor. The tetradentate macrocycle (maL) reacts with PbCl(2), PdCl(2) and different diamines in a 1:1:1 molar ratio in methanol to give several solid complexes of the types [Pb(maL)(R)Cl(2)] and [Pd(maL)(R)]Cl(2) (where R = 2,6-diaminopyridine or 1,2-phenylenediamine). The macrocycle and its metal complexes have been characterized by elemental analysis, molecular weight determinations, molar conductivity, IR, (1)H NMR, (13)C NMR, electronic, mass and electrochemical studies.

Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects.

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C(5)H(5)N(3))(2)M(2)'(R)(4)]Cl(2) (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C(5)H(7)N(3))(2)Cl(2) with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies.

Synthesis, characterization, in vitro and in vivo screening of unsymmetrical borole complexes of 2-hydroxy-N-phenylbenzamide and its derivatives.

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described.

Synthetic, Spectroscopic and Biocidal Aspects of Heterobimetallic Complexes Comprising Platinum(II) and a Group Four or Fourteen Element.

Heterobimetallic complexes with varying amines have been synthesized by the reaction of [Pt(C(2)H(8)N(2))(2)]Cl(2) with group four or fourteen organometallic dichlorides, viz., R(2)MCl(2) and Cp(2)M'Cl(2) in a 1:2 molar ratio in MeOH (where M=Si or Sn, M'= Ti or Zr and R=Ph or Me). These complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, conductance, IR, (1)H NMR and electronic spectra.