Blockchain for Electronic Vaccine Certificates: More Cons Than Pros?

Electronic vaccine certificates (EVC) for COVID-19 vaccination are likely to become widespread. Blockchain (BC) is an electronic immutable distributed ledger and is one of the more common proposed EVC platform options. However, the principles of blockchain are not widely understood by public health and medical professionals.

Automating Quantitative Measures of an Established Conventional MRI Scoring System for Preterm-Born Infants Scanned between 29 and 47 Weeks' Postmenstrual Age.

Background And Purpose: Conventional MR imaging scoring is a valuable tool for risk stratification and prognostication of outcomes, but manual scoring is time-consuming, operator-dependent, and requires high-level expertise. This study aimed to automate the regional measurements of an established brain MR imaging scoring system for preterm neonates scanned between 29 and 47 weeks' postmenstrual age.

Materials And Methods: This study used T2WI from the longitudinal Prediction of PREterm Motor Outcomes cohort study and the developing Human Connectome Project.

Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis.

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV decline in adolescence and adulthood have not slowed.

Appraisal of the quality of care of older adults with cognitive impairment in the emergency department.

The medical records of 273 patients 75 years and older were reviewed to evaluate quality of emergency department (ED) care through the use of quality indicators. One hundred fifty records contained evidence of an attempt to carry out a cognitive assessment. Documented evidence of cognitive impairment (CI) was reported in 54 cases.

Depth and distance perception of dentists and dental students.

The quality of work carried out by dentists is dependent, among other things, on experience, training, and manual dexterity. Historical focus on the latter as a predictor of dental performance has failed to recognize that dental competence also requires good perceptual and visual skills, not only for gathering information but also for judging positions, distances, and the size of objects and shapes. Most predictive tests ignore visual and interpretative deficiencies that could make individual acquisition of skills and interpretation of instructions difficult.

Science of assessment.

Psoriatic arthritis is a multisystem disorder which, from a measurement standpoint, demands consideration of its cutaneous manifestations and both axial and peripheral musculoskeletal involvement. Measurements of various aspects of impairment, ability/disability, and participation/handicap are feasible using existing measurement techniques, which are for the most part valid, reliable, and responsive. Nevertheless, there remain opportunities for the further development of consensus around core set measures and responder criteria, as well as for instrument development and refinement, standardised assessor training, cross-cultural adaptation of health status questionnaires, electronic data capture, and the introduction of standardised quantitative measurement into routine clinical care.

Comparative morphology of the pituitary gland in Australian flying foxes (Megachiroptera: genus Pteropus).

Background: Investigations of reproductive endocrinology of flying foxes (genus Pteropus) have been hampered by inadequate information on the normal morphology of the megachiropteran pituitary.

Methods: The novel technique of graphical three-dimensional (3-D) reconstruction, supported by more traditional anatomical techniques, have now been used to examine the shapes of, the interrelations between, the lobes of the pituitary of the little red flying fox, Pteropus scapulatus. Statistical analysis of data from three species tested whether there were changes in pituitary size with annual cycles in function, particularly with key stages of reproduction.

Interpretation of randomly amplified polymorphic DNA marker data for fingerprinting sweet potato (Ipomoea batatas L.) genotypes.

In this paper we present a method for the generation of randomly amplified polymorphic DNA (RAPD) markers for sweet potato. These were applied to produce genetic fingerprints of six clonal cultivars and to estimate genetic distances between these cultivars. The level of polymorphism within the species was extremely high.

The impact of chronic childhood illness on family stress: a comparison between autism and cystic fibrosis.

The study compared the different patterns of stress reported by mothers of children with either a chronic physical illness (cystic fibrosis), a chronic psychological disorder (autism), and children without a physical or psychological disorder. Twenty-four mothers from each of these three groups completed the Questionnaire on Resources and Stress Short Form (Holroyd & Guthrie, 1986). Each clinical group exhibited different patterns of stressful response consistent with the nature of the disorder and the requirements of care imposed on the families.

The neuropathology of chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat by inoculation with whole spinal cord and treatment with cyclosporin A.

Chronic relapsing experimental allergic encephalomyelitis was induced in Lewis rats by inoculation with guinea-pig spinal cord and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. In most animals, tail and limb weakness developed in a relapsing remitting pattern but in some these signs were persistent or progressive from onset. Histological studies during the early stages of clinically active disease (less than 25 days after inoculation) revealed inflammation and primary demyelination in the central nervous system (CNS), particularly the spinal cord, and in the peripheral nervous system (PNS), specifically the ventral and dorsal roots and dorsal root ganglia.