Clay-catalyzed ozonation of Norfloxacin - Effects of metal cation and degradation rate on aqueous media toxicity towards Lemna minor.

Norfloxacin was ozonized in aqueous montmorillonite suspensions and the resulting toxicity on Lemna minor was investigated for understanding the impact of natural partial oxidation of antibiotics on clay-containing ecosystems. Ion-exchanged montmorillonites (Mt) were used as catalysts because of their large occurrence in soils and aquatic media, while Lemna minor, an aquatic macrophyte is regarded as a bioindicator highly responsive to ecotoxicity change in the environment. NOF solutions exhibit intrinsic toxicity on L.

Differential bioaccumulation and histopathological changes induced by iron oxide nanoparticles and ferric chloride in the neotropical snail Biomphalaria glabrata.

Iron oxide nanoparticles (IONPs) are prominent in nanomedicine, cosmetics, and environmental applications. However, their increasing production, use, and release into the environment raises concerns about their potential risks to aquatic life and human health. This study aimed to evaluate the bioaccumulation, as concentration of small, medium and large iron aggregates in the digestive tubules, histopathological changes, and inflammatory responses in the freshwater snail Biomphalaria glabrata following chronic exposure to gluconic-acid functionalized IONPs (GLA-IONPs) compared to their dissolved counterpart (FeCl).

De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca).

Forests face an escalating threat from the increasing frequency of extreme drought events driven by climate change. To address this challenge, it is crucial to understand how widely distributed species of economic or ecological importance may respond to drought stress. In this study, we examined the transcriptome of white spruce (Picea glauca (Moench) Voss) to identify key genes and metabolic pathways involved in the species' response to water stress.

Evaluating carbon removal: Integrating technical potential with environmental, social, governance criteria, and sequestration permanence.

Climate modeling suggests that achieving international climate goals requires a reduction in current CO emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation, conducted by ENGIE's scientific council using an interdisciplinary Delphi panel methodology, proposes a "quality" measure for each technology.

Insights from multiple stable isotopes (C, N, Cl) into the photodegradation of herbicides atrazine and metolachlor.

Many processes can contribute to the attenuation of the frequently detected and toxic herbicides atrazine and metolachlor in surface water, including photodegradation. Multi-element compound-specific isotope analysis has the potential to decipher between these different degradation pathways as Cl is a promising tool for both pathway identification and a sensitive indicator of degradation for both atrazine and metolachlor. In this study, photodegradation experiments of atrazine and metolachlor were conducted under simulated sunlight in buffered solutions (direct photodegradation) and with nitrate (indirect photodegradation by OH radicals) to determine kinetics, transformation products and isotope fractionation for C, N and for the first time Cl.

Understanding the Needs and Experiences With Health Services of Gay and Bisexual Men (GBM) Who Engaged in Chemsex During the First Year of the COVID-19 Pandemic in Quebec, Canada.

Gay and bisexual men (GBM) engaging in chemsex can face various health and well-being-related challenges, the extent of which remains unknown given the limited research in the context of the COVID-19 pandemic. This paper examines the pandemic impacts on the health needs of GBM who engaged in chemsex and their experiences with related services. We applied interpretive description to produce knowledge with direct implications for improving practices and policies.

Integration of functional electrical stimulation during robotic-assisted intervention to increase bone mineral density in individuals with complete spinal cord injury: case report.

Introduction: A spinal cord injury (SCI) leads to an alteration of the central nervous system which significantly impacts the health, function and quality of life of those affected. Since SCI leads to a loss lower limbs usage, sublesional osteoporosis is a common and established consequence with high risk of fracture in this population. The mechanical loading remains the most effective approach to stimulate physiologic bone remodeling.

Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults.

In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55-85. Eighty-six of these participants were tested again two years later.

Byproduct-to-Host Ratios for Assessing the Accessibility of Mineral Resources.

Mineral resources are essential for reaching net-zero ambitions by 2050. There is a rising diversity of metals in electricity generation and storage technologies, as well as for mobility technologies. However, little is known about the future supply of minor elements historically mined in low volumes such as indium, tellurium, germanium, or tantalum.

Simultaneous assessment of membrane bilayer structure and drug insertion by F solid-state NMR.

Fluorine-19 is an ideal nucleus for studying biological systems using NMR due to its rarity in biological environments and its favorable magnetic properties. In this work, we used a mixture of monofluorinated palmitic acids (PAs) as tracers to investigate the molecular interaction of the fluorinated drug rosuvastatin in model lipid membranes. More specifically, PAs labeled at the fourth and eighth carbon positions of their acyl chains were coincorporated in phospholipid bilayers to probe different depths of the hydrophobic core.

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.

Rab7A has a key role in regulating membrane trafficking at late endosomes. By interacting with several different effectors, this small GTPase controls late endosome mobility, orchestrates fusion events between late endosomes and lysosomes, and participates in the formation of and regulates the fusion between autophagosomes and lysosomes. Rab7A is also responsible for the spatiotemporal recruitment of retromer, which is required for the endosome-to-trans-Golgi network retrieval of cargo receptors such as sortilin (SORT1) and CI-MPR (also known as IGF2R).

Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation.

HIV infection significantly affects the frequencies and functions of immunoregulatory CD3CD4CD8 double-negative (DN) T-cells, while the effect of early antiretroviral therapy (ART) initiation on these cells remains understudied. DN T-cell subsets were analyzed prospectively in 10 HIV+ individuals during acute infection and following early ART initiation compared to 20 HIV-uninfected controls. In this study, 21 Rhesus macaques (RMs) were SIV-infected, of which 13 were assessed during acute infection and 8 following ART initiation four days post-infection.

Implementing a Positive Behavior Support Program for Young Children with Autism in Public Agencies: A Social Validity Evaluation from Parents, Practitioners, and Administrators.

Challenging behaviors in young children with autism and intellectual disabilities pose significant barriers to learning and inclusion. The Prevent-Teach-Reinforce for Young Children (PTR-YC) program is an evidence-based intervention that addresses these behaviors according to Positive Behavior Intervention Support principles. It is essential to assess the social validity of an intervention, when implemented into a public service system, to ensure sustainability and relevance to stakeholders.

The Saint-Leonard Urban Glaciotectonic Cave Harbors Rich and Diverse Planktonic and Sedimentary Microbial Communities.

The terrestrial subsurface harbors unique microbial communities that play important biogeochemical roles and allow for studying a yet unknown fraction of the Earth's biodiversity. The Saint-Leonard cave in Montreal City (Canada) is of glaciotectonic origin. Its speleogenesis traces back to the withdrawal of the Laurentide Ice Sheet 13,000 years ago, during which the moving glacier dislocated the sedimentary rock layers.

Dynamic patterns of particulate matter concentration and size distribution in urban street canyons: insights into diurnal and short-term seasonal variations.

Time-varying characteristics of particulate matter (PM) pollution play a crucial role in shaping atmospheric dynamics, which impact the health and welfare of urban commuters. Previously published studies on the diurnal patterns of PMs are not consistent, especially in the context of field experiments in central China, and most field studies have only focused on particles with a single particle size. This study conducted regional-scale studies across 72 street canyon sets in Wuhan, China, investigated diurnal and seasonal PM concentration variations while also evaluating various PM size and the key driving factors.

Online yoga programme for resident physicians in Québec: an evaluation of feasibility and impact on mental health.

Objectives: To evaluate the feasibility of the Bali Yoga Programme for Residents (PYB-R), an 8-week virtual yoga-based intervention and determine its impact on the mental health of resident physicians.

Design: Single-group repeated measures study.

Setting: Associations from the four postgraduate medical education programmes in Québec, Canada.

Learning from educators: Implementation of a positive behavior support program targeting challenging behavior in children with autism.

Challenging behaviors (CB) are a frequent co-occurring problem in children with autism spectrum disorder (ASD) and hinder their response to recommended interventions such as early intensive behavioral intervention (EIBI). The Prevent-Teach-Reinforce for young children (PTR-YC) program was implemented to meet community-based EIBI educators' training and support needs in managing CB in their day-to-day work with families. Although this positive behavior support program has a strong empirical basis, its implementation by community-based educators has yet to be assessed from a systematic and structured program evaluation perspective.

M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge.

Current poultry vaccines against influenza A viruses target the globular head region of the hemagglutinin (HA1), providing limited protection against antigenically divergent strains. Experimental subunit vaccines based on the conserved ectodomain of the matrix protein 2 (M2e) induce cross-reactive antibody responses, but fail to fully prevent virus shedding after low pathogenic avian influenza (LPAI) virus challenge, and are ineffective against highly pathogenic avian influenza (HPAI) viruses. This study assessed the benefits of combining nanoparticles bearing three tandem M2e repeats (NR-3M2e nanorings or NF-3M2e nanofilaments) with an HA1 subunit vaccine in protecting chickens against a heterologous HPAI H5N1 virus challenge.

Predictors of stigma perception by people with type 1 diabetes: A cross-sectional analysis of the BETTER registry.

Aims: This study investigates stigma predictors across ages and genders, addressing a critical gap in understanding diverse populations to reduce related suboptimal clinical and psychosocial outcomes.

Methods: Cross-sectional analysis of self-reported data from BETTER, a Canadian registry of people with type 1 diabetes. Participants (n = 709) completed the 19-item-Diabetes-Stigma Assessment-Scale (DSAS-1) categorized into treated differently, blame and judgment, and identity concerns sub-scales.

A systematic review of mental health and climate change in the Philippines.

The Philippines are at the forefront of climate change impacts, including those related to health and well-being, but information on mental health and well-being are typically underreported. To help address this research lacuna, we conducted a systematic literature review. We aimed to provide an overview of current research knowledge and research gaps regarding the impacts of climate change outcomes on Filipinos' mental health and well-being.

Vulnerability of barley yields in Québec.

Climate projections across Québec indicate increased water stress and recurrent vulnerability of cropping systems. In recent years, reports of droughts and water stress have been recorded across the province. Many parts of Québec have experienced droughts in the past few years, which have had uninvestigated impacts on crops.

Altered memory CCR6 Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllers.

Background: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6 Th17-polarised CD4 T-cells are not fully restored in people with HIV (PWH). Moreover, long-lived Th17 cells contribute to HIV persistence under ART. However, the molecular mechanisms underlying these observations remain understudied.

Clinical symptoms and neuroanatomical substrates of daytime sleepiness in Parkinson's disease.

Clinical and neuroanatomical correlates of daytime sleepiness in Parkinson's disease (PD) remain inconsistent in the literature. Two studies were conducted here. The first evaluated the interrelation between non-motor and motor symptoms, using a principal component analysis, associated with daytime sleepiness in PD.