DefNEtTrp: An Iron Dual Chelator Approach for Anticancer Application.

Targeting iron metabolism has emerged as a novel therapeutic strategy for the treatment of cancer. As such, iron chelator drugs are repurposed or specifically designed as anticancer agents. Two important chelators, deferasirox (Def) and triapine (Trp), attack the intracellular supply of iron (Fe) and inhibit Fe-dependent pathways responsible for cellular proliferation and metastasis.

Is trauma associated with plant-based diet choice?

Examinations of links between plant-based diets (e.g., vegetarian and vegan diets) and indices of physical and mental health have received increased attention in the scientific literature in recent years.

Elucidating the High Affinity Copper(II) Complexation by the Iron Chelator Deferasirox Provides Therapeutic and Toxicity Insight.

Tinoco A-Team Deferasirox (Def), an orally administered iron-chelating drug, has drawn significant interest in repurposing for anticancer application due to the elevated Fe demand by cancer cells. But there are also concerns about its severe off target health effects. Herein Cu(II) binding is studied as a potential off target interaction.

Are Patients who are Diagnosed with Hypertension or Diabetes more likely to Receive the COVID-19 Booster? Data from PR-CEAL's Community Survey Tool.

Objective: Evaluate the relationship between diabetes and hypertension and COVID-19 booster uptake.

Methods: Members of the Community Outreach Group of the Puerto Rico Community Engagement Alliance Against COVID-19 Disparities (PR-CEAL) administered a survey at 229 community events between November 2021 and May 2023. Information on 2,145 participants' sociodemographic information and chronic disease diagnoses was gathered.

Critical Overview of Current Drug Abuse in Puerto Rico based on Governmental Data.

The abuse of psychoactive substances poses a critical public health challenge in Puerto Rico, with far-reaching implications for both individuals and society as a whole. This article provides a comprehensive overview of the patterns and trends associated with drug abuse in Puerto Rico, focusing on alcohol, tobacco, cannabis, benzodiazepines, opioids, and methadone. Recent statistics reveal a concerning increase in substance abuse, particularly among young adults.

A high-efficiency and long-cycling aqueous indium metal battery enabled by synergistic In/K interactions.

Aqueous trivalent metal batteries are promising options for energy storage, owing to their ability to transfer three electrons during redox reactions. However, advances in this field have been limited by challenges such as incompatible M/M electrode potentials and salt hydrolysis. Herein, we identify the trivalent indium metal as a viable candidate and demonstrate a high-performance indium-Prussian blue hybrid battery using a K/In mixture electrolyte.

Unveiling BaTiO-SrTiO as Anodes for Highly Efficient and Stable Lithium-Ion Batteries.

Amidst the swift expansion of the electric vehicle industry, the imperative for alternative battery technologies that balance economic feasibility with sustainability has reached unprecedented importance. Herein, we utilized Perovskite-based oxide compounds barium titanate (BaTiO) and strontium titanate (SrTiO) nanoparticles as anode materials for lithium-ion batteries from straightforward and standard carbonate-based electrolyte with 10% fluoroethylene carbonate (FEC) additive [1M LiPF (1:1 EC: DEC) + 10% FEC]. SrTiO and BaTiO electrodes can deliver a high specific capacity of 80 mA h g at a safe and low average working potential of ≈0.

Enhancing Electrochemical Performance of Si@CNT Anode by Integrating SrTiO Material for High-Capacity Lithium-Ion Batteries.

Silicon (Si) has attracted worldwide attention for its ultrahigh theoretical storage capacity (4200 mA h g), low mass density (2.33 g cm), low operating potential (0.4 V vs.

Enhancing Access Through Language-Tailored Approach in Telehealth and Veterans Video Connect: Traumatic Brain Injury (TBI) Veterans Satisfaction Assessment.

Introduction: Traumatic brain injury (TBI) can impact language processing, necessitating language-tailored approaches. Telehealth may expand rural Veterans' access but has unknown feasibility for language preferences. This study explored telehealth/Veterans Video Connect satisfaction for Spanish/English TBI screening.

Alginate-Based UV Sensor: A Simple and Inexpensive Tool for Educational Purposes.

This document presents a simple yet highly effective demonstration for creating UV radiation sensors using alginate molecules. This demonstration can easily be aligned with the Next Generation Science Standards (NGSS) for classroom use. Moreover, the demonstration requires only a few easily obtainable materials, and the process involved is straightforward.

Shifts in the gut microbiota of sea urchin associated with the 2022 disease outbreak.

Introduction: In recent decades, Caribbean coral reefs have lost many vital marine species due to diseases. The well-documented mass mortality event of the long-spined black sea urchin in the early 1980s stands out among these collapses. This die-off killed over 90% of changing the reefscape from coral to algal-dominated.

Geometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties.

Iron oxide nanoparticles (IONPs) are recognized for their potential in biomedical applications due to their distinctive physicochemical properties. This study investigates the synthesis of IONPs with various geometric morphologies-cubic, star-like, truncated icosahedron, and spherical-via thermal decomposition to enhance their utility in magnetic resonance imaging (MRI) and targeted drug delivery. X-ray diffraction analysis verified the FeO phase in all nanoparticles, illustrating the synthesis's efficacy.

Increasing culturally relevant science media coverage: exploring the outcomes of a collaboration in Puerto Rico.

CienciaPR, a nonprofit that brings together the largest network of Puerto Rican scientists and one of the largest networks of Hispanic/Latine scientists in the world, has collaborated with El Nuevo Día (END), Puerto Rico's newspaper of record, to increase culturally relevant stories in their science section. This Practice Insight quantifies and compares the presence of culturally relevant elements (e.g.