Optimization of a mass spectrometric analytical method for the quality assessment of insulin and its analogs.

The principal aim of this study was to optimize analytical methodology based on mass spectrometry for the evaluation of the quality of recombinant human insulin and its analogs. In this study ESI-MS was used to assess the quality of human insulin, short acting insulin analogs, insulin lispro, insulin aspart and insulin glulisine and long acting analogs including insulin glargine, insulin degludec, and insulin detemir, in respective pharmaceutical formulations. In this study, with the aimed to optimize analytical conditions, different factors influencing the analytical performance such as pH, ionic strength, sample dilution, organic solvent addition were addressed.

sp. nov. (Trichoptera, Limnephilidae), a new species of the species cluster from the Ibër River Basin in Kosovo.

Background: The species cluster comprises species with limited distribution, currently documented from Kosovo, Serbia, Bosnia and Herzegovina and Bulgaria.

New Information: In this paper, we describe a new species, sp. nov.

sp. n. (Trichoptera, Limnephilidae), a new species from the Sharr Mountains, Republic of Kosovo.

Background: The Sharr Mountains are one of the most important hotspots of terrestrial and freshwater biodiversity in the Balkan Peninsula, with many endemic and rare species. The caddisfly studies in this area increased during the past years, although insufficiently investigated areas still remain.

New Information: In this paper, we describe a new species, sp.

sp. n. (Trichoptera: Limnephilidae), a new species from Bjeshkët e Nemuna National Park in the Republic of Kosovo, with molecular and ecological notes.

Background: The Western Balkans are an important hotspot of caddisfly diversity in Europe, with several microscale endemics, many of which were discovered during the recent years. The genus Wallengren, 1891 likely originated and diversified in Europe, with the Balkan Peninsula being one of the most important diversity hotspots.

New Information: In this paper, we describe the new species sp.

Generation of flavor compounds by biotransformation of genetically modified hairy roots of (L.) with basidiomycetes.

Altogether, 14 basidiomycetes (12BAD, 95PCH, 9WCOC, 5PSA, 96BCI, 331SHIBD, 4MSC, 74HFA, 220MPS, 115PFLA, 111 ICO C, 16LED, 6TSU, and 61LYP) were grown on solid and in liquid media using hairy roots of genetically modified (L.) as the only source of carbon and nitrogen. After the first screening by GC-MS/MS-O, two fungi (115PFLA and 61LYP) which resulted in the most pleasant complex natural flavor by biotransformation were selected for further analysis.

Distribution of two rare taxa of caddisflies (Trichoptera: Rhyacophilidae, Polycentropodidae) from the Republic of Kosovo.

Background: The knowledge about distribution, ecology and species composition of caddisflies of the Balkan Peninsula is still not complete. The ongoing investigations of the last years highlight this area as an important hotspot of caddisfly diversity. has been considered a narrow range endemic of Slovenia and surrounding areas.

Culture of antibiotic use in Kosovo - an interview study with patients and health professionals.

Background: Kosovo is a new state and has a high consumption of antibiotics in relation to other European countries. Existing quantitative studies have shown that practices exist that is not optimal when it comes to antibiotic use in Kosovo, this includes citizens' use of antibiotics, pharmacy practices of selling antibiotics without prescriptions and physicians' prescribing behaviours. To address these problems, there is a need for a deeper understanding of why antibiotics are handled in a suboptimal way.

Role of MRI in Cervical Spondylotic Myelopathy with Other Pathological Findings: Case Report and Literature Review.

Introduction: Cervical spondylotic myelopathy (CSM) is a neck condition that arises when the spinal cord becomes compressed due to the wear-and-tear changes that occur in the spine as we age.

Case Report: The patient was a 52-year-old male, who complains of neck pain, paranesthesia in upper extremities, lower back pain and bilateral calf pain, muscle weakness in the lower and upper extremities, fatigue and general body pain that started four weeks ago associated with other clinical manifestation. Magnetic Resonance Imaging (MRI) of the cervical spine revealed canal stenosis and increased T2 signal within the spinal cord.