Pro-inflammatory diet affects markers of iron metabolism in healthy older adults.

Background: Inflammation and inadequate nutrition are common in older age and known to affect iron homeostasis. However, it is not known whether a pro-inflammatory diet affects iron status in older adults. We investigated the diet quality of healthy older adults considering markers of iron homeostasis and inflammation compared to a younger control.

Optimization of a Mobile Transdiagnostic Emotion Regulation Intervention for University Students: A Micro-Randomized Trial.

Increasing mental health problems among university students highlight the need for scalable, effective solutions. We have developed a transdiagnostic mobile intervention called ROOM, promoting adaptive emotion regulation (ER) skills among university students. Understanding how the intervention works and optimising content and delivery is essential for creating an effective and adaptive system.

The Heisenberg-RIXS instrument at the European XFEL.

Resonant inelastic X-ray scattering (RIXS) is an ideal X-ray spectroscopy method to push the combination of energy and time resolutions to the Fourier transform ultimate limit, because it is unaffected by the core-hole lifetime energy broadening. Also, in pump-probe experiments the interaction time is made very short by the same core-hole lifetime. RIXS is very photon hungry so it takes great advantage from high-repetition-rate pulsed X-ray sources like the European XFEL.

Organization of the stalk system on electrocytes in mormyrid weakly electric fish Campylomormyrus compressirostris.

The adult electric organ in weakly electric mormyrid fish consists of action-potential-generating electrocytes, structurally and functionally modified skeletal muscle cells. The electrocytes have a disc-shaped portion and, on one of its sides, numerous thin processes, termed stalklets. These unite to stalks leading to a single main stalk that carries the innervation site.

cfDNA UniFlow: a unified preprocessing pipeline for cell-free DNA data from liquid biopsies.

Background: Cell-free DNA (cfDNA), a broadly applicable biomarker commonly sourced from urine or blood, is extensively used for research and diagnostic applications. In various settings, genetic and epigenetic information is derived from cfDNA. However, a unified framework for its processing is lacking, limiting the universal application of innovative analysis strategies and the joining of data sets.

Heads up-Four Giraffa species have distinct cranial morphology.

Giraffe (Giraffa spp.) are among the most unique extant mammals in terms of anatomy, phylogeny, and ecology. However, aspects of their evolution, ontogeny, and taxonomy are unresolved, retaining lingering questions that are pivotal for their conservation.

Vocabulary trajectories in German-speaking children from 18 months to three years: a growth mixture model.

Children acquire vocabulary at different growth rates. The aim of this study was to identify subgroups of different vocabulary trajectories in a community sample of L1 German-speaking children aged 1;6 to 3;0 to enlarge the understanding of vocabulary trajectories. Parents filled out vocabulary checklists at four measurement times, each six months apart.

A data-integrative modeling approach accurately characterizes the effects of mutations on Arabidopsis lipid metabolism.

Collections of insertional mutants have been instrumental for characterizing the functional relevance of genes in different model organisms, including Arabidopsis (Arabidopsis thaliana). However, mutations may often result in subtle phenotypes, rendering it difficult to pinpoint the function of a knocked-out gene. Here, we present a data-integrative modeling approach that enables predicting the effects of mutations on metabolic traits and plant growth.

Dementia with lewy bodies patients with high tau levels display unique proteome profiles.

Background: Clinical studies have long observed that neurodegenerative disorders display a range of symptoms and pathological features and, in some cases, overlap, suggesting that these diseases exist on a spectrum. Dementia with Lewy Bodies (DLB), a synucleinopathy, is a prominent example, where symptomatic similarities with tauopathy, Alzheimer's disease, are observed. Although tau pathology has been observed in DLB, the interplay between tau and α-synuclein is poorly understood at a molecular level.

Craving induction through virtual reality cue-exposure for patients with alcohol dependence in rehabilitation treatment.

New therapeutic approaches for alcohol dependence (AD) include virtual reality (VR)-based treatments offering scalable options for cue exposure (CE), a well-established strategy in cognitive behavioral therapy. This study aimed to evaluate the feasibility and tolerability of a new VR-CE paradigm. On an explorative basis, factors influencing the induction of craving were examined.

The role of anthropogenic influences on a tropical lake ecosystem and its surrounding catchment: a case study of Lake Sentani.

Lake Sentani is a tropical lake in Indonesia, consisting of four interconnected sub-basins of different water depths. While previous work has highlighted the impact of catchment composition on biogeochemical processes in Lake Sentani, little is currently known about the microbiological characteristics across this unique ecosystem. With recent population growth in this historically rural area, the anthropogenic impact on Lake Sentani and hence its microbial life is also increasing.

The origin and evolution of shrews (Soricidae, Mammalia).

Shrews are among the most speciose of mammalian clades, but their evolutionary history is poorly understood. Their fossil record is fragmentary and even the anatomy of living groups is not well documented. Here, we incorporate the oldest, most complete fossil shrew yet known into the first phylogenetic analysis of the group to include molecular, morphological and temporal data.

Shrimp structure as a test bed for ordinal pattern measures.

Identifying complex periodic windows surrounded by chaos in the two or higher dimensional parameter space of certain dynamical systems is a challenging task for time series analysis based on complex network approaches. This holds particularly true for the case of shrimp structures, where different bifurcations occur when crossing different domain boundaries. The corresponding dynamics often exhibit either period-doubling when crossing the inner boundaries or, respectively, intermittency for outer boundaries.

Understanding teachers' perspectives on students with epilepsy in Germany: A survey examining knowledge, experience, and affective, cognitive, and behavioral attitudes to inform teacher training.

The comprehensive teacher survey (N = 210 teachers), conducted in Germany, focused on a broad range of student needs (medical, instructional, and emotional), and captured teachers' knowledge about epilepsy and experiences with students with epilepsy (SWE), alongside multiple attitudes towards SWE. Results reveal gaps in teachers' understanding of appropriate responses to seizures, exemplified by 33 % believing an object should be put into the mouth during a seizure. Misconceptions about the risks of physical activity for SWE are prevalent among teachers (6.

Nature or nurture: genetic and environmental predictors of adiposity gain in adults.

Background: Previous prediction models for adiposity gain have not yet achieved sufficient predictive ability for clinical relevance. We investigated whether traditional and genetic factors accurately predict adiposity gain.

Methods: A 5-year gain of ≥5% in body mass index (BMI) and waist-to-hip ratio (WHR) from baseline were predicted in mid-late adulthood individuals (median of 55 years old at baseline).

Benefits and harms associated with the use of AI-related algorithmic decision-making systems by healthcare professionals: a systematic review.

Background: Despite notable advancements in artificial intelligence (AI) that enable complex systems to perform certain tasks more accurately than medical experts, the impact on patient-relevant outcomes remains uncertain. To address this gap, this systematic review assesses the benefits and harms associated with AI-related algorithmic decision-making (ADM) systems used by healthcare professionals, compared to standard care.

Methods: In accordance with the PRISMA guidelines, we included interventional and observational studies published as peer-reviewed full-text articles that met the following criteria: human patients; interventions involving algorithmic decision-making systems, developed with and/or utilizing machine learning (ML); and outcomes describing patient-relevant benefits and harms that directly affect health and quality of life, such as mortality and morbidity.

Potato Late Blight Outbreak: A Study on Advanced Classification Models Based on Meteorological Data.

While past research has emphasized the importance of late blight infection detection and classification, anticipating the potato late blight infection is crucial from the economic point of view as it helps to significantly reduce the production cost. Furthermore, it is necessary to minimize the exposure of potatoes to harmful chemicals and pesticides due to their potential adverse effects on the human immune system. Our work is based on the precise classification of late blight infections in potatoes in European countries using real-time data from 1980 to 2000.

Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case-Control Analysis Within the EPIC Study.

: Nutrimetabolomics may reveal novel insights into early metabolic alterations and the role of dietary exposures on prostate cancer (PCa) risk. We aimed to prospectively investigate the associations between plasma metabolite concentrations and PCa risk, including clinically relevant tumor subtypes. : We used a targeted and large-scale metabolomics approach to analyze plasma samples of 851 matched PCa case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort.

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Cellular mechanisms of copper neurotoxicity in human, differentiated neurons.

Copper (Cu) is an essential trace element involved in fundamental physiological processes in the human body. Even slight disturbances in the physiological Cu homeostasis are associated with the manifestation of neurodegenerative diseases. While suggesting a crucial role of Cu in the pathogenesis, the exact mechanisms of Cu neurotoxicity involved in the onset and progression of neurological diseases are far from understood.

An Optimized Ex Vivo n-3 PUFA Supplementation Strategy for Primary Human Macrophages Shows That DHA Suppresses Prostaglandin E2 Formation.

Evidence suggests beneficial effects of long-chain n-3 polyunsaturated fatty acids (PUFAs) in inflammatory diseases. However, the underlying mechanisms are still subject of research. For this purpose, we developed an ex vivo n-3 PUFA supplementation strategy.

Linking 24-hour movement behaviour guidelines to core symptoms and school engagement of youth with moderate/severe ADHD.

Background: The independent associations of physical activity (PA), sleep duration (SL), and screen time (ST) with health outcome measures have been well-documented among children and adolescents, but not in youth with moderate/severe ADHD. To this end, the present study aimed to investigate the associations between three components within 24-hour movement behaviour (24-HMB) framework and core symptoms and school engagement in youth with moderate/severe ADHD.

Methods: This study used pooled data from the 2021-2022 U.

Sulfobetaine ionic liquid crystals based on strong acids: phase behavior and electrochemistry.

A group of new zwitterion based ionic liquid crystals (ILCs) have been synthesized. Depending on the counter anion (mesylate or hydrogen sulfate) the phase behavior of the resulting ILCs is quite different. Mesylate based ILCs show complex phase behavior with multiple phases depending on the alkyl chain length.