A Multilayer Network Model for Motor Competence from the View of the Science of Complexity.

Motor competence is related to a large number of correlates of different natures, forming together a system with flexible parts that are synergically and cooperatively connected to produce a wide range of motor outcomes that cannot be explained from a predetermined linear view or a unique mechanism. The diversity of interacting correlates, the various connections between them, and the fast changes between assessments at different time points are clear barriers to the study of motor competence. In this manuscript, we present a multilayer framework that accounts for the theoretical background and the potential mathematical procedures necessary to represent the non-linear, complex, and dynamic relationships between several underlying correlates that emerge as a motor competence network.

Love as a Commitment Device : Evidence from a Cross-Cultural Study across 90 Countries.

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

Isoquinolinequinone N-oxides with diverging mechanisms of action induce collateral sensitivity against multidrug resistant cancer cells.

Multidrug resistance (MDR) is a major challenge in cancer research. Collateral sensitizers, compounds that exploit the enhanced defense mechanisms of MDR cells as weaknesses, are a proposed strategy to overcome MDR. Our previous work reported the synthesis of two novel Isoquinolinequinone (IQQ) N-oxides that induce collateral sensitivity in MDR ABCB1-overexpressing non-small cell lung cancer (NSCLC) and colorectal cancer cells.

Touch Empowerment: Self-Sustaining e-Tattoo Thermoelectric System for Temperature Mapping.

In recent advancements within sensing technology, driven by the Internet of Things (IoT), significant impacts are observed on health sector applications, notably through wearable electronics like electronic tattoos (e-tattoos). These e-tattoos, designed for direct contact with the skin, facilitate precise monitoring of vital physiological parameters, including body heat, a critical indicator for conditions such as inflammation and infection. Monitoring these indicators can be crucial for early detection of chronic conditions, steering toward proactive healthcare management.

Corrective Actions Taxonomy for Healthcare Incidents (CATHI): Insights From Real-world Data on Hospital-reported Incidents.

Objectives: This study aimed to develop a taxonomy for classifying corrective actions following health care incidents in a Portuguese tertiary hospital.

Methods: The study utilized a multimethods design, combining qualitative and quantitative analyses of real-world data. Thematic analysis was performed, drawing on inductive and deductive approaches.

Adherence, risk perception, and attitudes towards colorectal cancer screening: A road to individualized screening?

Background & Aims: Colorectal cancer (CRC) ranks second globally in cancer-related deaths and there is ongoing debate on the best populational screening strategy. This study aimed to evaluate individuals' intention to adhere to CRC screening, screening method preference, and barriers to screening.

Methods: Cross-sectional study conducted in northern Portugal, where a populational fecal occult blood test (FOBT) program is implemented.

A scoping review of participatory approaches in child maltreatment research across Europe.

Background: Participatory approaches in child maltreatment (CM) research increasingly focus on involving children, youth, and adults as co-researchers. However, little is known about their use in Europe.

Objective: To review the European literature on participatory approaches in CM research.

Chemical characterization and antioxidant potential of Arthrospira sp., Thalassiosira sp., and Raphidonema sp.

Microalgae are emerging as valuable sources of bioactive compounds. This study evaluates hexane extracts from Thalassiosira sp. and Raphidonema sp.

Ptosis in human immunodeficiency virus-infected patients under long-term antiretroviral treatment.

Objective: To present cases of ptosis in HIV-1 patients on long-term antiretroviral therapy (ART) and review the existing literature.

Methods: Five HIV-1-positive patients with slowly progressive bilateral ptosis underwent a comprehensive diagnostic evaluation, including imaging studies, neurophysiological testing, muscle biopsy, and genetic analysis. A literature review was conducted.

Comparison of sexual function between laparoscopic lateral suspension and laparoscopic sacrocervicopexy with the use of the PISQ-IR questionnaire.

Introduction And Hypothesis: We aimed to analyze the quality of sexual life of patients with apical vaginal wall prolapse who had undergone laparoscopic lateral suspension (LLS) and laparoscopic sacrocolpopexy (LSC).

Methods: We performed a secondary analysis of sexual outcomes of a previous randomized control trial comparing LLS and LSC in 89 women with symptomatic POP stage ≥ II. We evaluated sexually active (SA) and non-sexually active women (NSA) using the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire-IUGA-Revised (PISQ-IR).

Enhancing the European power system resilience with a recommendation system for voluntary demand response.

Climate change, geopolitical tensions, and decarbonization targets are bringing the resilience of the European electric power system to the forefront of discussion. Among various regulatory and technological solutions, voluntary demand response can help balance generation and demand during periods of energy scarcity or renewable energy generation surplus. This work presents an open data service called Interoperable Recommender that leverages publicly accessible data to calculate a country-specific operational balancing risk, providing actionable recommendations to empower citizens toward adaptive energy consumption, considering interconnections and local grid constraints.

Reducing the Travel Burden for Patients to Access Specialized Medicines in Paraná, Brazil.

Objectives: This study aimed to evaluate the potential reduction in distance and travel time with a hypothetical municipal distribution of specialized component medicines in the state of Paraná.

Methods: This was a cross-sectional study. Distances and travel times from all the 1025 residential locations in the state of Paraná to dispensing pharmacies were calculated in 2 different models: centralized model with drugs dispensed in the 22 state-owned pharmacies and decentralized model with drugs dispensed in the 399 municipal pharmacies.

Genome-informed Discovery of Monchicamides A-K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532.

Genome mining has emerged as an important tool for the discovery of natural products and is particularly effective for the swift identification of ribosomally synthesized and post-translationally modified peptides (RiPPs). Among RiPPs, cyanobactins have gained attention due to their diverse structures and bioactive properties. Here, we explored the Microcoleaceae cyanobacterium LEGE 16532 strain and identified the biosynthetic gene cluster (BGC), which was predicted to encode cyanobactin-like molecules.

The impact of extract on pharmacokinetics of phenytoin in rats.

Epilepsy patients are at a higher risk of developing overweight and obesity. Given the thermogenic properties of (Guarana), this study aimed to evaluate a potential pharmacokinetic interaction between extract and phenytoin in rats. Two pharmacokinetic studies were developed with and phenytoin: a coadministration and a pre-treatment study.

New evidence for baroreflex and respiratory chemoreflex-mediated cerebral sympathetic activation in humans.

The brain is highly innervated by sympathetic nerve fibers; however, their physiological purpose is poorly understood. We hypothesized that unilateral cerebral norepinephrine (NE) spillover, an index of cerebral sympathetic nerve activity (SNA), would be elevated when engaging the baroreflex [via lower-body negative pressure (LBNP; -20 and -40 Torr)] and respiratory chemoreflexes [via carbon dioxide (CO) administration (+8 Torr)], independently and in combination. Twelve young and healthy participants (five females) underwent simultaneous blood sampling from the right radial artery and internal jugular vein.

Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts.

Background: Allergic rhinitis (AR) is a highly prevalent disease. We aimed to assess the symptoms that physicians who see patients with AR perceive as the most bothersome in their patients.

Methods: We performed a cross-sectional study based on an online questionnaire sent to all members of the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative.

Physical activity patterns in adolescents: A longitudinal study.

The present study aimed at describing and comparing the physical activity (PA) patterns of adolescents from a middle-income country over a 4-year period. This is a longitudinal observational study (four waves of data collection, 2014-2017) with 668 adolescents aged 10-13 years in 2014 (mean age of 11.8 ± 0.

Integrating OMICS-based platforms and analytical tools for diagnosis and management of pancreatic cancer: a review.

Cancer remains the second leading cause of death worldwide, surpassed only by cardiovascular disease. From the different types of cancer, pancreatic cancer (PaC) has one of the lowest survival rates, with a survival rate of about 20% after the first year of diagnosis and about 8% after 5 years. The lack of highly sensitive and specific biomarkers, together with the absence of symptoms in the early stages, determines a late diagnosis, which is associated with a decrease in the effectiveness of medical intervention, regardless of its nature - surgery and/or chemotherapy.

Putting gluten back on menu - Safety assessment of polyphenol-rich wheat varieties in Celiac Disease.

This study provides a comprehensive proteomic and metabolomic analysis of novel anthocyanin- and carotenoid-rich wheat varieties to assess their immunogenicity in the context of Celiac Disease. Using (semi)-quantitative mass spectrometry, the research found that gliadin expression and peptide release, particularly those containing immunostimulatory γ-gliadin epitopes, vary significantly across different wheat varieties. While non-targeted mass spectrometry provided valuable insights, the study acknowledged potential methodological biases, such limitations of ion current intensity as a measure of peptide abundance.

Enterococcus hirae Bacteremia Associated With Traumatic Soft Tissue Infection: A Case Report.

In recent years, reports of infections in humans have increased. Similarly to most known Enterococci, has been identified mostly in bacteremia, urinary tract infections, infective endocarditis, and biliary tract infections. We present a case of bacteriemia associated with traumatic soft tissue infection in a 77-year-old male patient, a polytrauma victim with a tibia-fibula open fracture after a forklift accident.

Intestinal Pseudo-Obstruction After Vincristine Use.

A 73-year-old man presented with nausea, abdominal discomfort, and distention persisting for the past five days. He had previously been diagnosed with stage III peripheral CD4+ T cell lymphoma and had initiated chemotherapy comprising vincristine two weeks prior to presentation. An evaluation revealed diffuse colon distention and pneumatosis intestinalis without mechanical obstruction, consistent with acute colonic pseudo-obstruction.

Photocatalytic Oxidative Coupling of Benzyl Alcohol and Benzylamine for Imine Synthesis Using Immobilized CsBiBr Perovskite.

The oxidative cross-coupling of benzyl alcohol (BA) and benzylamine (BZA) is employed for the production of the corresponding imine, N-benzylidenebenzylamine (BZI), under visible light irradiation (light-emitting diodes (LE with λ = 417 nm) and mild reaction conditions. The cesium bismuth halide perovskites (CsBiBr, CBB) are synthesized by a one-step solution process as a sustainable alternative for the widely used Pb-halide perovskites. The CBB photocatalyst is immobilized on a polyethylene terephthalate (PET) structure designed explicitly for three-dimensional (3D) printing to operate in both batch and continuous modes to overcome the need for a final catalyst separation step.

Applicability of the Scottish screen-detected polyp cancer study (SSPoCS) algorithm in a multicentric cohort in the management of malignant colorectal polyps.

Background/objectives: Robust evidence regarding the management after endoscopic resection of malignant colorectal polyps (MCP) is lacking. Inconsistencies in reporting on potential prognostic factors hinder the decision process. To address these issues, the Scottish Screen-detected Polyp Cancer Study (SSPoCS) introduced an algorithm based in two easily obtainable variables: resection margin and lymphovascular invasion.

Differential expression of metabolic enzymes in testicular germ cell tumors: The impact of glycolytic metabolism in embryonal carcinoma histotype.

Background: Testicular germ cell tumors are the most common solid malignancies in young men, with increasing incidence worldwide. Broadly classified into seminomas and non-seminomas, they exhibit distinct biological behaviors and responses to treatment. Although metabolic reprogramming is an acknowledged cancer hallmark, metabolic pathways in testicular germ cell tumors remain poorly understood.