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Within-Host Genotypic and Phenotypic Diversity of Contemporaneous Carbapenem-Resistant Klebsiella pneumoniae from Blood Cultures of Patients with Bacteremia.
mBio
December 2022
University of Pittsburghgrid.471408grid.21925, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- Bacterial bloodstream infections (BSIs) may involve a mix of different organisms rather than just single pathogens, specifically investigating the behavior of carbapenem-resistant Klebsiella pneumoniae (CRKP).
- Researchers analyzed 10 strains of CRKP from 6 patients, revealing genetic and phenotypic diversity among strains within individual patients, indicating significant variations in antibiotic resistance and virulence factors.
- The findings challenge traditional beliefs about BSIs being caused by a single organism, suggesting that understanding within-host microbial diversity could change infection management and treatment strategies.