1 results match your criteria: "University of Pittsburghgrid.412689.0grid.21925.3d School of Medicine[Affiliation]"
Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis.
Microbiol Spectr
October 2022
Department of Microbiology and Molecular Genetics, University of Pittsburghgrid.412689.0grid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- Chronic rhinosinusitis (CRS) is a significant but often overlooked condition in cystic fibrosis (CF) patients, with treatment of upper airway issues potentially improving lower airway health.
- A study involving 27 adults with CF CRS identified that sinus microbial communities were unstable and often dominated by Pseudomonas aeruginosa and staphylococci, leading to unique and fluctuating compositions during periods of symptoms.
- The research found that lower microbial diversity in the sinuses correlated with worse disease symptoms and increased inflammation markers (like IL-1β), highlighting a relationship between sinus health and overall respiratory disease in CF patients.