1 results match your criteria: "University of Pittsburgh and the Children's Hospital of Pittsburgh of UMPC[Affiliation]"
Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice.
Gastroenterology
October 2018
Department of Pediatric Gastroenterology, University of Pittsburgh and the Children's Hospital of Pittsburgh of UMPC, Pittsburgh, Pennsylvania. Electronic address:
Background & Aims: Pancreatitis after endoscopic retrograde cholangiopancreatography (PEP) is thought to be provoked by pancreatic ductal hypertension, via unknown mechanisms. We investigated the effects of hydrostatic pressures on the development of pancreatitis in mice.
Methods: We performed studies with Swiss Webster mice, B6129 mice (controls), and B6129 mice with disruption of the protein phosphatase 3, catalytic subunit, βisoform gene (Cnab mice).