2 results match your criteria: "University of Pittsburgh Medical Center and the University of Pittsburgh Cancer Institute[Affiliation]"
Histopathology of Graft-vs-Host Disease of Gastrointestinal Tract and Liver: An Update.
Am J Clin Pathol
May 2016
From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY;
Objectives: Graft-vs-host disease (GVHD) is a donor T-cell-mediated disorder affecting the recipient's skin, gastrointestinal tract, lungs, and liver. It complicates up to 70% of hematopoietic cell transplantation and is associated with high morbidity and mortality rates.
Methods: An extensive review of the literature has been performed to include the most current consensus on the histopathologic diagnosis of gastrointestinal and liver GVHD.
The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.
Leuk Res
August 2006
Department of Medicine, University of Pittsburgh Medical Center and the University of Pittsburgh Cancer Institute, USA.
The PML protein localizes to regions of the nucleus known as nuclear bodies or PODs. However, in t(15;17) Acute Promyelocytic Leukemia (APL) blasts, PML is found in a micro-punctate pattern. In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML.
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