A Rapid One-Pot Synthesis of Novel High-Purity Methacrylic Phosphonic Acid (PA)-Based Polyhedral Oligomeric Silsesquioxane (POSS) Frameworks via Thiol-Ene Click Reaction.

Herein, we demonstrate a facile methodology to synthesis a novel methacrylic phosphonic acid (PA)-functionalized polyhedral oligomeric silsesquioxanes (POSSs) via thiol-ene click reaction using octamercapto thiol-POSS and ethylene glycol methacrylate phosphate (EGMP) monomer. The presence of phosphonic acid moieties and POSS-cage structure in POSS-S-PA was confirmed by Fourier transform infrared (FT-IR) and nuclear magnetic resonance (¹H, Si and P-NMR) analyses. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrum of POSS-S-PA acquired in a dithranol matrix, which has specifically designed for intractable polymeric materials.

Non-enolisable Knoevenagel condensate appended Schiff bases-metal (II) complexes: Spectral characteristics, DNA-binding and nuclease activities.

New Schiff base complexes [Cu(L)Cl] (1), [Ni(L)Cl] (2), [Zn(L)Cl] (3), and [Fe(L)HOCl] (4) {L=(4E)-3-(2-hydroxybenzylidene)-4-(2-hydroxyphenylimino)pentan-2-one, L=2,2'-(1E,1'E)-(3-(2-hydroxybenzylidene)-pentane-2,4-diylidene)bis(azan-1-yl-1 idene)diphenol} have been synthesized and characterized by elemental analysis, UV-Vis, IR, FAB-mass, EPR, spectral studies and electrochemical studies, the ligands L &L were characterized by H and C NMR spectra. Complex 1 show a visible spectral d-d band near 600nm and display cyclic voltammetric quasireversible response for the Cu(II)/Cu(I) couple vs Ag/AgCl in DMSO. The EPR spectrum of 1 show g>g suggesting a square planar geometry around copper with d as the ground state.

Monistic dualism and the body electric: An ontology of disease, patient and clinician for person-centred healthcare.

Ontology is involved in medical care, because what both doctors and patients think the disease, the patient and the doctor are affects the giving and receiving of care, and hence the definition of medical care as profession. Going back to ancient philosophical views of disease as 'bounded entity' or as 'relation' (still echoed in contemporary theories and mindsets), I propose a way to think ontologically about disease that places it in necessary connection with the patient as person. Drawing on Augustine's views on disease, bodily integrity, and the human person as mind-body unit, I speak of 'monistic dualism' as the view where the unit and health of the person is continuously and personally generated by the mind's attention to and action on the body, whether the body is impaired or not.

The Protective Role of Thiourea on Leuciscus cephalus Exposed to Sublethal Doses of Pendigan 330EC (Pendimethalin) Herbicide.

The aim of the study was to investigate the protective role of thiourea on the physiological, hematological, biochemical and histopathological parameters of Leuciscus cephalus exposed to sublethal concentration of Pendigan 330 EC herbicide. The animals were divided in four experimental groups (control, animals subjected to 1 ‰ thiourea, animals subjected to 4 × 10(-4) mL/L herbicide and, respectively, animals subjected to 4 × 10(-4) mL/L herbicide and 1 ‰ thiourea). Exposure of European chub to herbicide administered in water for 2 weeks determined installation of pathological changes in the liver and gills tissues.

Diffuse large B-cell lymphoma and polycythemia vera discovered at the onset - a rare association and its possible importance in lymphoma prognosis.

Unlabelled: Diffuse large B-cell lymphoma (DLBCL) represent the most frequently non-Hodgkin's lymphoma (NHL) (over 30%), especially in developing countries. Many associations of NHL with another neoplasia were described following chemotherapy or radiotherapy regimens. The coexistence of DLBCL with myeloproliferative neoplasms (MPNs) JAK2V617F positive at the onset was very rare reported in the literature.

Thickness Influence on Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition.

We report a study on the biocompatibility thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their cytotoxicity was assessed according to ISO 10993-5 [1]. Extensive physical-chemical analyses have been carried out on the deposited structures with various thicknesses in order to explain the differences in biological behavior: profilometry, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction and surface energy measurements.

Changes in spectrochemical and catalytic properties of biopolymer anchored Cu(II) and Ni(II) catalysts by electron beam irradiation.

Chitosan (a biopolymer) anchored Cu(II) and Ni(II) Schiff base complexes, [M(OIAC)Cl2] (M: Cu/Ni and OIAC: ([2-oxo-1H-indol-3-ylidene]amino)chitosan) were electron beam irradiated by different doses (100 Gy, 1 kGy and 10 kGy). The electron beam has shown potential impact on biopolymer's support, in detail chain linking and chain scissoring, as evidenced by viscosity studies, FT-IR and X-ray diffraction spectroscopic techniques. Due to these structural changes, thermal properties of the complexes were found to be changed.

Synthesis, characterization, biological evaluation and docking studies of macrocyclic binuclear manganese(II) complexes containing 3,5-dinitrobenzoyl pendant arms.

A series of bis(phenoxo) bridged binuclear manganese(II) complexes of the type [Mn2L(1-3)](ClO4)2 (1-3) containing 3,5-dinitrobenzoyl pendant-arms have been synthesized by cyclocondensation of 2,6-diformyl-4-R-phenols (where R=CH3, C(CH3)3 or Br) with 2,2'-3,5-dinitrobenzoyliminodi(ethylamine) trihydrochloride in the presence of manganese(II) perchlorate. The IR spectra of complexes indicate the presence of uncoordinated perchlorate anions. The UV-Vis spectra of complexes suggest the distorted octahedral geometry around manganese(II) nuclei.

Patients' substantialization of disease, the hybrid symptom and metaphysical care.

In the context of current scholarship concerned with facilitating integration between the biomedical and the patient-centred models of care, the article suggests that disease brings about an ontological disruption in patients, which is not directly addressed in either model, and may interfere with treatment and therapy outcomes if not met with a type of care termed here as 'metaphysical'. The receipt of diagnosis and medical care can give patients the sense that they are ontologically diminished, or less of a human, and along with physicians' approaches to and discourses about disease, may prompt them to seek ontological restoration or security in the same way as psychologically traumatized patients sometimes do: by treating the disease and/or the experience of harm associated with it as a thing that exists per se. I call this 'substantialization' of disease (or harm) and draw on Augustine's theory of non-substantial deficiencies (physiological and moral) and on Plato's and Plotinus's different takes on such defects in order to discuss what substantialization can do for patients.

Synthesis, structural elucidation, biological, antioxidant and nuclease activities of some 5-Fluorouracil-amino acid mixed ligand complexes.

Some biologically active mixed ligand complexes (1-9) have been synthesized from 5-Fluorouracil (5-FU; A) and amino acids (B) such as glycine (gly), L-alanine (ala) and L-valine (val) with Ni(II), Cu(II) and Zn(II) ions. The synthesized mixed ligand complexes (1-9) were characterized by various physico-chemical, spectral, thermal and morphological studies. 5-Fluorouracil and its mixed ligand complexes have been tested for their in vitro biological activities against some pathogenic bacterial and fungal species by the agar well diffusion method.

Religiosity and Proactive Coping with Social Difficulties in Romanian Adolescents.

Even though medical and psychological sciences and services evolved so much, in many cases, the healing process has its mystery, and some recoveries seem to be entirely magical. Especially in such cases, religion seems to play an important role, as it helps people face the "mystery" of the healing process and integrate it. Religion has helped people face potentially traumatic events with minimum consequences for their health, or, moreover, to use these experiences for personal development, making them more prepared for life challenges.

Bio-sensitive activities of coordination compounds containing 1,10-phenanthroline as co-ligand: synthesis, structural elucidation and dna binding properties of metal(II) complexes.

Present work reports the DNA binding and cleavage characteristics of a series of mixed-ligand complexes having the composition [M(L)(phen)2]Cl2 (where M=Cu(II), Ni(II), Co(II) and Zn(II) and phen as co-ligand) in detail. Their structural features and other properties have been deduced from their elemental analyses, magnetic susceptibility and molar conductivity as well as from IR, UV-Vis, (1)H NMR and EPR spectral studies. The UV-Vis, magnetic susceptibility and EPR spectral data of metal complexes suggest an octahedral geometry.

Numerical model (switchable/dual model) of the human head for rigid body and finite elements applications.

In this paper, a methodology for the development and validation of a numerical model of the human head using generic procedures is presented. All steps required, starting with the model generation, model validation and applications will be discussed. The proposed model may be considered as a dual one due to its capabilities to switch from deformable to a rigid body according to the application's requirements.

Solar physical vapor deposition preparation and microstructural characterization of TiO2 based nanophases for dye-sensitized solar cell applications.

Titanium dioxide exists in three crystalline phases: anatase, rutile and brookite. Although rutile is thermodynamically more stable, anatase is considered as the most favorable phase for photocatalysis and solar energy conversion. Recent studies have shown a significant improvement of light harvesting and overall solar conversion efficiency of anatase nanoparticles in dye-sensitized solar cells (DSSCs) when using a mixture of anatase and rutile phases (10-15% rutile).

Management of traumatic injury prevention in sports training and competition.

The paper had as an applicative objective the epidemiological analysis of the appearance of traumatic injuries in athletes during competitions and trainings. In the period the athletes have been followed (one year), 426 traumatic injuries have been registered in 87 athletes who were analyzed in the study. Most of them were mild injuries, to which recovery has been made quite rapidly.

Bioacoustics response of small benign or malignant nodules.

One of the most important features of separation between benign or malignant tissues is their smooth or rough shape. This article presents a new method for early diagnosis of thyroid cancer by knowing the resonance frequencies of a certain tissue. Two types of nodules were investigated: spherical and elliptical.

Multispectral acoustic investigation of a thyroid geometrical model.

The aim of this paper is to present a new noninvasive method for investigating the homogeneity of the thyroid gland geometric model. The amplitude of reflected signal depends on the shape, size and homogeneity of the object investigated acoustic as well as the signal frequency emitted by generator. The eigenvalues proportional to the resonance frequencies are obtained by using finite element method applied to discretized form of differential equations of sound propagation.

The immunohistochemical localization of synaptophysin protein (p38) in the gastro-entero-pancreatic (GEP) system of reptiles.

The gastro-entero-pancreatic (GEP) system of four reptilian species: turtle (Emys orbicularis), lizards (Lacerta viridis and Lacerta agilis) and snake (Natrix natrix) has been investigated immunohistochemically for the presence and topographic distribution of synaptophysin. Among the studied reptiles, only in turtles were neural, glial and neuroendocrine elements labelled for this marker protein. Semi-quantitative evaluation of the immunolabelled neural structures distributed throughout the gastroenteric wall revealed, with two exceptions, highly significant mean differences between the successive gut segments.

Serotonin (5-hydroxytryptamine, 5-HT) immunoreactive endocrine and neural elements in the chromaffin enteropancreatic system of amphibians and reptiles.

The diffuse chromaffin enteropancreatic system of nine species of amphibians (newts, frogs) and reptiles (turtles, lizards, snakes) was investigated immunohistochemically for the presence and topographic distribution of serotonin (5-hydroxytryptamine, 5-HT). The study revealed various numbers of serotonin-producing cells in the pancreas and intestinal epithelium and also immunolabelled nerve profiles in the villi of all species studied. In addition, two different morphological populations of serotonin cells ("open" and "closed") were localized in the functional segments of the intestines in the representative species of all the taxa investigated.