Advances in surface-enhanced Raman spectroscopy-based sensors for detection of various biomarkers.

Surface enhanced Raman spectroscopy (SERS) allows the ultrasensitive detection of analytes present in traces or even single molecule levels by the generation of electromagnetic fields. It is a powerful vibrational spectroscopic method that is capable to detect traces of chemical and biological analytes. SERS technique is involved in the extremely sophisticated studies of molecules with high specificity and sensitivity.

Novel GdTaO phase for efficient photocatalytic degradation of organic dye under visible light irradiation: An X-ray spectroscopic investigation.

The novel GdTaO phase exhibits good photocatalytic activity under visible light irradiation and holds great promise for the removal of organic dyes from industrial wastes. The GdTaO samples were synthesized using the hydrothermal and calcination process with different weight ratios of gadolinium nitrate hydrate (G) and tantalum pentachloride (T), and their structural studies confirmed the formation of the GdTaO (GT) phase. Among the samples, GT-4 (with a weight ratio of 4:1) exhibited the highest photocatalytic activity for the degradation of Methyl Orange (MO) dye under visible light irradiation.

Monoclonal Antibodies and Antibody-drug Conjugates as Emerging Therapeutics for Breast Cancer Treatment.

When breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer.

Analysing role of airborne particulate matter in abetting SARS-CoV-2 outbreak for scheming regional pandemic regulatory modalities.

The mutating SARS-CoV-2 necessitates gauging the role of airborne particulate matter in the COVID-19 outbreak for designing area-specific regulation modalities based on the environmental state-of-affair. To scheme the protocols, the hotspots of air pollutants such as PM, PM, NH, NO, NO, SO, and and environmental factors including relative humidity (RH), and temperature, along with COVID-19 cases and mortality from January 2020 till December 2020 from 29 different ground monitoring stations spanning Delhi, are mapped. Spearman correlation coefficients show a positive relationship between SARS-COV-2 with particulate matter (PM with r > 0.

Chemical composition, pesticidal activities and in-silico investigation of Hedychium spicatum Sm. chloroform extract.

The present study aimed to identify the bioactive constituents in the chloroform extract of H. spicatum rhizomes (HS-RCLE), further evaluated for its in-vitro pesticidal activities validating via molecular docking techniques. GC/MS analysis of HS-RCLE identified 14 compounds contributing 84.

A bibliometric survey of research trends in vitrimer.

The recent trends of vitrimer studies enhance the thermoset material with superior properties, therefore, it is particularly important to address the critical scientific inquiries in this area using their research metrics. The reported vitrimer systems have been highly required for future real-time applications; however, the inquisitiveness of material exchange mechanisms extends the research studies further. Significantly, more scientific information's are required to achieve the evident prospective outcomes these materials.

Analysis of retail sector research evolution and trends during COVID-19.

The purpose of this study is to analysis the evolution of the retail sector during the COVID-19 period and to identify future research issues. Scopus databases were searched for articles published in English between 2020 and 2022 to discover current trends and concerns in the retail industry. A total of 1071 empirical and nonempirical studies were compiled as a result of the evaluation process.

Active microfluidic reactor-assisted controlled synthesis of nanoparticles and related potential biomedical applications.

Fabricating high-performance nanoparticles (NPs) is currently a focus of researchers due to their manipulative size-dependent unique properties required to develop next-generation advanced systems. To harness the unique properties of NPs, maintaining identical characteristics throughout the processing and application process system is crucial to producing uniform-sized, or monodisperse, NPs. In this direction, mono-dispersity can be achieved by exerting extreme control over the reaction conditions during the NP synthesis process.

High-Performance Graphene-Modified Sensing Chip for SARS-CoV-2 Detection.

This sensing prototype model involves the development of a reusable, twofold graphene oxide (GrO)-glazed double inter-digitated capacitive (DIDC) detecting chip for detecting severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) specifically and rapidly. The fabricated DIDC comprises a Ti/Pt-containing glass substrate glazed with graphene oxide (GrO), which is further chemically modified with EDC-NHS to immobilize antibodies (Abs) hostile to SARS-CoV-2 based on the spike (S1) protein of the virus. The results of insightful investigations showed that GrO gave an ideal engineered surface for Ab immobilization and enhanced the capacitance to allow higher sensitivity and low sensing limits.

Intriguing physicochemical properties and impact of co-dopants on N-doped graphene oxide based ZnS nanowires for photocatalytic application.

Superparamagnetic N-doped graphene oxide (GO)- with ZnS nanowires was synthesized by a one-step hydrothermal method by doping dilute amounts of Ga, Cr, In, and Al ions for water treatment and biomedical applications. In these experiments, to enhance their properties, 2% of Ga, In, and or Al were codoped along with 2% Cr ions in these ZnS nanowires. The nanocomposite with the composition, InCrZnS, has better photocatalytic efficiency than other co-doped nanocomposites.

Transition metal complexes as self-activating chemical nucleases: proficient DNA cleavage without any exogenous redox agents.

Chemical nucleases have found potential applications in the research fields of chemistry, biotechnology and medicine. A variety of metal complexes have been explored as good to outstanding therapeutic agents for DNA cleavage activity most likely hydrolytic, oxidative or photoinduced cleavage pathways. However, most of these DNA cleaving agents lack their utility in applications due to their dependence on exogenous oxidants or reductants to achieve successful DNA damage.

Electronic structure and defect-induced luminescence study of phase-stabilized t-ZrO nanocrystals.

Luminescent tetragonal-ZrO (t-ZrO ) nanocrystals were synthesized using an optimized combustion method without post-synthesis annealing and characterized using X-ray diffraction, electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, UV-Vis. spectroscopy, photoluminescence spectroscopy, thermoluminescence (TL), and vibrating sample magnetometry. The as-synthesized t-ZrO nanocrystals have a bandgap of 4.

State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer.

The development of new therapeutic strategies is on the increase for prostate cancer stem cells, owing to current standardized therapies for prostate cancer, including chemotherapy, androgen deprivation therapy (ADT), radiotherapy, and surgery, often failing because of tumor relapse ability. Ultimately, tumor relapse develops into advanced castration-resistant prostate cancer (CRPC), which becomes an irreversible and systemic disease. Hence, early identification of the intracellular components and molecular networks that promote prostate cancer is crucial for disease management and therapeutic intervention.

Carrier transport and photoconductivity properties of BN/NiO nanocomposite films.

BN/NiO and Au-loaded BN/NiO nanocomposite films were separately fabricated on the glass substrates for carrier transport and photoconductivity properties. X-ray diffraction pattern of the films show the hexagonal structure of BN and presence of defect states by Nelson Riley factor analysis. Morphological images show spherical shaped particles with highly porous structure.

Aspects of Nanotechnology for COVID-19 Vaccine Development and Its Delivery Applications.

Coronavirus, a causative agent of the common cold to a much more complicated disease such as "severe acute respiratory syndrome (SARS-CoV-2), Middle East Respiratory Syndrome (MERS-CoV-2), and Coronavirus Disease 2019 (COVID-19)", is a member of the coronaviridae family and contains a positive-sense single-stranded RNA of 26-32 kilobase pairs. COVID-19 has shown very high mortality and morbidity and imparted a significantly impacted socioeconomic status. There are many variants of SARS-CoV-2 that have originated from the mutation of the genetic material of the original coronavirus.

Reactive oxygen species affect the potential for mineralization processes in permeable intertidal flats.

Intertidal permeable sediments are crucial sites of organic matter remineralization. These sediments likely have a large capacity to produce reactive oxygen species (ROS) because of shifting oxic-anoxic interfaces and intense iron-sulfur cycling. Here, we show that high concentrations of the ROS hydrogen peroxide are present in intertidal sediments using microsensors, and chemiluminescent analysis on extracted porewater.

Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer's: Design, Synthesis, and Biological Evaluation.

As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer's disease (AD), its inhibition is a promising approach for treating AD. Sulindac is an NSAID of the aryl alkanoic acid class, consisting of a indene moiety, which showed neuroprotective behavior in recent studies. In this study, newer Indene analogs were synthesized and evaluated for their in vitro AChE inhibition.

A Novel Generative Adversarial Network-Based Approach for Automated Brain Tumour Segmentation.

: Medical image segmentation is more complicated and demanding than ordinary image segmentation due to the density of medical pictures. A brain tumour is the most common cause of high mortality. : Extraction of tumorous cells is particularly difficult due to the differences between tumorous and non-tumorous cells.

Isolation and biological evaluation of demethylcassiarin B from Lam.

In search of potential natural products for the amelioration of obesity, phytochemical investigation of leaves of Lam. was carried out. It led to the isolation of demethycassiarin B (), 6,8-dihydroxy-3-methyl-1H isochromenone (), and 6-hydroxymellein ().

Preparation and Optimization of Liposome Containing Thermosensitive Nasal Hydrogel System for Brain Delivery of Sumatriptan Succinate.

Drug absorption is improved by the intranasal route's wide surface area and avoidance of first-pass metabolism. For the treatment of central nervous system diseases such as migraine, intranasal administration delivers the medication to the brain. The study's purpose was to develop an nasal hydrogel that contained liposomes that were loaded with sumatriptan succinate (SS).

Single-Cell DNA Methylation Analysis in Cancer.

Morphological, transcriptomic, and genomic defects are well-explored parameters of cancer biology. In more recent years, the impact of epigenetic influences, such as DNA methylation, is becoming more appreciated. Aberrant DNA methylation has been implicated in many types of cancers, influencing cell type, state, transcriptional regulation, and genomic stability to name a few.