The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.

BACKGROUND The aim of the study was to investigate the role of von Willebrand factor (vWF), the vWF-cleaving protease, ADAMTS13, the composition of thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke. MATERIAL AND METHODS A prospective cohort study included 131 patients with ischemic stroke (<6 hours) with or without intravenous thrombolysis. Interventional procedure parameters, hemocoagulation markers, vWF, ADAMTS13, and histological examination of the extracted thrombi were performed.

Ethanol-induced flushing with topical pimecrolimus use.

Topical calcineurin inhibitor use has been implicated in a flushing reaction associated with ethanol ingestion. This adverse effect has mostly been described as occurring with the application of tacrolimus ointment, and one report associated it with the use of pimecrolimus cream. We present three cases of ethanol-induced flushing in patients who used topical pimecrolimus.

Representing task context: proposals based on a connectionist model of action.

Representations of task context play a crucial role in shaping human behavior. While the nature of these representations remains poorly understood, existing theories share a number of basic assumptions. One of these is that task representations are discrete, independent, and non-overlapping.

Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9).

Hyperinsulinaemia in the fasting state and a blunted insulin secretory response to acute glucose stimulation are commonly observed in obesity associated non-insulin-dependent diabetes mellitus. Hyperlipidaemia is a hallmark of obesity and may play a role in the pathogenesis of this beta-cell dysfunction because glucose metabolism in pancreatic beta cells may be altered by the increased lipid load. We tested this hypothesis by assessing the chronic effect of oleic acid on glucose metabolism and its relationship with glucose-induced insulin release in beta HC9 cells in tissue culture.