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Statin Therapy and Risk of Acute Memory Impairment.
JAMA Intern Med
August 2015
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia3Center for Pharmacoepidemiology Research and Training, University of Pennsylvania Perelm.
Importance: Reports on the association between statins and memory impairment are inconsistent.
Objective: To assess whether statin users show acute decline in memory compared with nonusers and with users of nonstatin lipid-lowering drugs (LLDs).
Design, Setting, And Participants: Using The Health Improvement Network database during January 13, 1987, through December 16, 2013, a retrospective cohort study compared 482,543 statin users with 2 control groups: 482,543 matched nonusers of any LLDs and all 26,484 users of nonstatin LLDs.