ACCELERATE - Five years accelerating cancer drug development for children and adolescents.

Rapid evaluation and subsequent regulatory approval of new drugs are critical to improving survival and reducing long-term side-effects for children and adolescents with cancer. The international multi-stakeholder organisation ACCELERATE was created to advance the timely investigation of new anti-cancer drugs. ACCELERATE has enhanced communication and understanding between academia, industry, patient advocates and regulators.

The rise of tele-mental health in perinatal settings.

We discuss the use of tele-mental health in settings serving expectant parents in fetal care centers and parents with children receiving treatment in neonatal intensive care units within a pediatric institution. Our emphasis is on the dramatic rise of tele-mental health service delivery for this population in the wake of the onset of the COVID-19 pandemic in the U.S.

[The development of nursing research ten years after the establishment of PhD Schools of Nursing in Italy].

Introduction: In Italy, the nursing doctoral programs were established in 2006, and after ten years we though it would be important to understand how nursing research in Italy has developed thanks to its four doctoral schools of nursing. Our research question was: How have the Italian doctoral schools of nursing contributed to the development of nursing research in the last ten years?

Methods: A national descriptive observational was conducted to collect all the publications made by the four nursing doctoral schools in Florence, Genoa, L'Aquila, and Rome between 2006 and 2015. For the enrolment of the participants, an online survey was sent to the e-mail address of each student provided by the reference University.

A Dynamic Dual Process Model of Intertemporal Choice.

Dual process theories of decision making describe choice as the result of an automatic System 1, which is quick to activate but behaves impulsively, and a deliberative System 2, which is slower to activate but makes decisions in a rational and controlled manner. However, most existent dual process theories are verbal descriptions and do not generate testable qualitative and quantitative predictions. In this paper, we describe a formalized dynamic dual process model framework of intertemporal choice that allows for precise, experimentally testable predictions regarding choice probability and response time distributions.

Identifying Risk and Management of Acute Haemodynamic Decompensation During Catheter Ablation of Ventricular Tachycardia.

Radiofrequency catheter ablation (CA) has an established role in the management of patients with structural heart disease presenting with recurrent ventricular tachycardia (VT). Due to the complex underlying substrate, high burden of comorbidities and concomitant heart failure (HF) status, these patients may be at higher risk of periprocedural complications. The prolonged low-output state related to VT induction and mapping, as well as the fluid overload due to irrigated CA and the use of general anaesthesia, may decompensate the HF status, leading to multiple-organ failure and increase in early post-procedural mortality.

Identifying predictors of high sodium excretion in patients with heart failure: a mixed effect analysis of longitudinal data.

Background: A low-sodium diet is a core component of heart failure self-care but patients have difficulty following the diet.

Aim: The aim of this study was to identify predictors of higher than recommended sodium excretion among patients with heart failure.

Methods: The World Health Organization Five Dimensions of Adherence model was used to guide analysis of existing data collected from a prospective, longitudinal study of 280 community-dwelling adults with previously or currently symptomatic heart failure.

Penetration of zona-free hamster ova as a test to assess fertilizing ability of bull sperm after frozen storage.

Frozen stored sperm samples of two Holstein bulls (A and B) were compared for their abilities to interact with zona-free hamster ova. The percentage of hamster vitelli interacting with sperm from Bull A was significantly higher than that interacting with sperm from Bull B (94.5% vs.