Patterns of the innate immune response in tambaqui Colossoma macropomum: Modulation of gene expression in haemorrhagic septicaemia caused by Aeromonas hydrophila.

The production of tambaqui Colossoma macropomum has recently reached a milestone, being considered the main native species produced in South American continental waters. Despite the importance of this fish, its immunity is not well understood. In this study we established some patterns of innate immunity for the species via two experiments.

Bibliometric approach to the perspectives and challenges of membrane separation processes to remove emerging contaminants from water.

The presence of contaminants in water is concerning due to the potential impacts on human health and the environment, and ingested contaminants cause harm in various ways. The conventional water treatment systems are not efficient to remove these contaminants. Therefore, novel techniques and materials for the removal of contaminants are increasingly being developed.

Taurine-mediated aggression is abolished via 5-HT antagonism and serotonin depletion in zebrafish.

Taurine is one of the most abundant amino acids in vertebrates involved in important physiological functions, including osmoregulation, membrane stability, and neuronal activity. The pleiotropic effects of taurine support the existence of different mechanisms of action (e.g.

Performance of Genetically Modified Soybean Expressing the Cry1A.105, Cry2Ab2, and Cry1Ac Proteins Against Key Lepidopteran Pests in Brazil.

The pyramided genetically modified (GM) soybean [Glycine max L. (Merr.)] MON87751 × MON87708 × MON87701 × MON89788, expressing Cry1A.

Coelioscopic-assisted prefemoral ovariosalpingectomy in a d`Orbigny slider (Trachemys dorbigni) using a digital otoscope.

The purpose of this study was to assess the unilateral prefemoral coelioscopic-assisted approach for ovariosalpingectomy in a d`Orbigny slider (Trachemys dorbigni) using a digital otoscope. Twenty healthy turtles were randomly assigned to one of two groups, for right (GR; n=10) or left (GL; n=10) prefemoral access, for coelioscopic-assisted ovariosalpingectomy. Anesthesia and surgery times, body weight, and ovary/oviduct weight data were recorded.

Co-immobilization of amylases in porous crosslinked gelatin matrices by different reticulations approaches.

The aim of this study was to carry out the co-immobilization of α-amylase and glucoamylase in crosslinked gelatin porous supports. For this, two methods of co-immobilization were proposed based on the crosslinking with glutaraldehyde (Ggta) or CaCl in presence of alginate (Gcal). The supports characterization revealed a porous microstructure with good interaction between its components according to the FTIR analysis and thermal properties.

Tildipirosin: An effective antibiotic against Glaesserella parasuis from an in vitro analysis.

Tildipirosin is a latest generation macrolide that is used to battle infection diseases caused by Gram-negative bacteria. Recent studies have shown the effectiveness of this antimicrobial agent against ; however, little information is available about , the etiological agent of Glässer's disease. In this study, the Tildipirosin activity to 100 Brazilian clinical isolates of was assessed using a broth microdilution assay.

CHRONIC EXPOSURE TO METHYLPHENIDATE-CONTAMINATED WATER ELICITS SOCIAL IMPAIRMENT TO ZEBRAFISH.

Residual contamination of water with MPH represents a severe environmental issue because it can affect non-target animals. Here we describe the behavioral effects in zebrafish after chronic contamination of water containing residues of MPH (0.1875, 1.

Dopamine and serotonin mediate the impact of stress on cleaner fish cooperative behavior.

Stress is known to modulate behavioral responses and rapid decision-making processes, especially under challenging contexts which often occur in social and cooperative interactions. Here, we evaluated the effects of acute stress on cooperative behavior of the Indo-Pacific cleaner wrasse (Labroides dimidiatus) and the implications of pre-treatment with monoaminergic compounds: the selective serotonin reuptake inhibitor - fluoxetine, the 5-HT receptor antagonist - WAY-100,635, the D receptor agonist - SKF-38393, and the D receptor antagonist - SCH-23390. We demonstrated that stress decreased the predisposal to interact and increased cortisol levels in cleaners, which are alleviated by fluoxetine and the dopaminergic D antagonist.

Biological Properties of (Dunal), an Amazonian Fruit.

is an Amazonian fruit (cubiu) that has been domesticated since pre-Colombian era. It is also used in folk medicine to treat some clinical conditions. This investigation chemically characterized and analyzed the antioxidant and antitumoral effect of a cubiu pulp/seed hydroalcoholic extract.

"Hey assistant, how can I become a donor?" The case of a conversational agent designed to engage people in blood donation.

Background: People have insufficient knowledge and many misconceptions about the blood donation process, which hampers donors recruitment. Therefore, novel strategies and resources are needed to provide information and improve these circumstances.

Objective: We aimed at an interactive conversational agent to explain about blood donation.

Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish.

Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research.

Effects of harvesting Spirulina platensis biomass using coagulants and electrocoagulation-flotation on enzymatic hydrolysis.

This study aimed to assess the harvesting of Spirulina platensis using coagulants and electrocoagulation-flotation (ECF) and to evaluate its influence on enzymatic hydrolysis. Using nine chemical coagulants, we obtained a biomass harvesting efficiency of up to 99.5%.

The impact of housing environment color on zebrafish anxiety-like behavioral and physiological (cortisol) responses.

Color of the environment is an important factor modulating human and animal behavior and physiology. Animal models are a valuable tool to understand how colors affect social, cognitive and affective responses. The zebrafish (Danio rerio) is rapidly emerging as an important organism in neuroscience and physiology.

Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models.

Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders.

Effects of using a mobile health application on the health conditions of patients with arterial hypertension: A pilot trial in the context of Brazil's Family Health Strategy.

Brazil's Family Health Strategy (FHS) leads public health policies and actions regarding community health, addressing arterial hypertension (AH) in primary care settings. In this scenario, the use of communication technologies becomes appropriate for the monitoring of patients with AH. To preliminary verify the intervention approach and the effects of using an m-Health application on the health conditions of patients with AH for a future study, we conducted a non-randomized, controlled, non-blind trial (N = 39), comparing the use of a mobile health app (m-Health) with conventional AH monitoring over 3 months.

Simultaneous saccharification and fermentation of Spirulina sp. and corn starch for the production of bioethanol and obtaining biopeptides with high antioxidant activity.

The aim was to produce bioethanol by the simultaneous saccharification and fermentation (SSF) of Spirulina sp. LEB 18 biomass and corn starch, increasing the process scale and obtaining biopeptides from bioethanol residue. Different temperatures of SSF and biomass/starch concentrations were tested, and the best conditions were chosen to scale-up the bioethanol production.

Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish.

Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g.

Sex differences in adult zebrafish anxiolytic-like responses to diazepam and melatonin.

Sex differences are an important variable in biomedical research. The zebrafish (Danio rerio) is rapidly becoming a critical novel model organism in translational neuroscience and neuropharmacology. Here, we examine the effects of sex on locomotor activity and anxiety-like behavior in adult zebrafish tested in the novel tank test following their exposure to two clinically relevant, common anxiolytic drugs diazepam and melatonin.

Use of dupilumab on the treatment of moderate-to-severe asthma: a systematic review.

Objective: The objective of this article was to conduct a systematic review of the treatment of moderate-to-severe asthma by administrating Dupilumab.

Methods: A search on the online databases EBSCO, Scielo, PubMed, Medline Bireme, Lilacs, and The New England Journal of Medicine was conducted, publications from 2010 to 2018 were selected. The inclusion criteria were articles which contained control groups, tested the validity of Dupilumab, and verified the response of patients through controlled tests.

Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish.

Stressful experiences are related to the triggering of anxiety and mood disorders. Tryptophan (amino acid precursor of serotonin synthesis) emerges as important treatment of these disorders. Here, we evaluate the effects of pre-treatment with tryptophan (300 mg/L) and fluoxetine (50 μg/L) in response to acute stress in zebrafish.

Zebrafish as a Model of Neurodevelopmental Disorders.

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs, possessing both high physiological homology to humans and sensitivity to pharmacological and genetic manipulations.

Mobile health applications for chronic diseases: A systematic review of features for lifestyle improvement.

Aims: To identify mobile health applications with features for improving the lifestyle of patients with chronic diseases.

Methods: We performed a systematic literature review between November 2017 and May 2018 on the Virtual Health Library's interface. A total of 816 records were identified.

Accordance and reproducibility of the electronic version of the WHOQOL-BREF and WHOQOL-OLD questionnaires.

Introduction: Evidence of the validity of instruments for assessing health-related quality of life (QOL) are fundamental to grant interpretations and direct actions at the level of promotion and health care.

Purpose: To verify the agreement and reproducibility of the QOL assessment instruments WHOQOL-Bref and WHOQOL-Old, in paper (PV) and electronic version (EV), called WHOQOL-Bref web and WHOQOL-Old web, respectively.

Subjects And Method: A cross-sectional study was performed with 98 elderly people, separated into two groups, from Tapejara-RS, Brazil, during 2016 and 2017.