2 results match your criteria: "University of Otago P.O. Box 913[Affiliation]"
Polycystic kidney disease - where gene dosage counts.
F1000Prime Rep
June 2014
Department of Pathology, Dunedin School of Medicine, University of Otago P.O. Box 913, Dunedin, 9054 New Zealand.
Gene dosage effects have emerged as playing a central role in the pathogenesis of polycystic kidney disease. Yet, how gene dosage can ultimately have an impact on the formation of kidney cysts remains unknown. In this commentary we review the evidence for the role of gene dosage effects versus the "2-hit" mutation model in polycystic kidney disease (PKD), and also discuss how gene networks may potentially make intertwined contributions to PKD.
View Article and Find Full Text PDFPrediction of distal radius fracture in children, using a biomechanical impact model and case-control data on playground free falls.
J Biomech
February 2006
Injury Prevention Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago P.O. Box 913, Dunedin, New Zealand.
Objectives: To assess the ability of a biomechanical impact model to predict the likelihood of distal radius fracture in children using data gathered for a previous epidemiological case-control study of falls from playground equipment.
Methodology: Factor of Risk (FR) values were generated for each of selected subjects from the case-control study using a biomechanical model. Logistic regression curves were fitted to examine the relationship between the FR values and the probability of radius fracture.