Protective effect of the selective estrogen receptor modulator LY117018 on rat vaginal Candida albicans colonization.

Although we know that estrogen promotes vaginal colonization with Candida albicans in oophorectomized rats, the availability of selective estrogen receptor modulators (SERMs) raises the question of whether these compounds may influence the susceptibility of vaginal epithelium to Candida colonization. We inoculated rats with viable C. albicans 2 days after treatment with oil vehicle (controls), estradiol cypionate or the proprietary SERM, LY117018.

Business ethics and health care: the re-emerging institution-patient relationship.

Managed care poses a challenge to the traditional conceptualization of medicine and of the physician-patient relationship. People have evaluated the merits of managed care by focusing upon the way its incentives alter the relationship between physician and patient. However, this misses the key to rightly evaluating MCOs.

Reptilian melanomacrophages function under conditions of hypothermia: observations on phagocytic behavior.

Melanomacrophages (MMs) were removed from livers of turtles of three North American families and cultured. J774 mammalian macrophages were similarly cultured and the MMs were exposed to E. coli(fluor) at approximately 2, 7, 27, and 37 degrees C.

Achilles tendon rupture. Diagnosis and management.

Achilles tendon rupture is one of the most common tendon failures that affects the lower extremity. Several podiatric and orthopedic publications discuss the various treatment options for this rupture. This review intends to increase the physician's awareness of risk factors that contribute to Achilles tendon rupture and of how these factors should be considered in the decision-making process.

Stimulation-induced behavioral inhibition: a new model for understanding physical violence.

Physical violence is widely considered to result from action carried out with the intention of causing injury; that is, from aggression. However, the "hypothesis" of aggression is inapplicable in all but a few instances as well as inappropriate for many destructive, rage-associated responses directed at inanimate objects. This paper outlines a new perspective on physical violence, reinterpreting many behaviors hitherto labeled aggressive as stimulation-seeking behaviors (SSBs) above an arbitrary level of intensity.

Allometric scaling of isokinetic peak torque: the Nebraska Wrestling Study.

Allometric scaling has been used increasingly in the exercise sciences to control statistically for body size differences in physical performance variables. The purpose of this study was to use multivariate allometric scaling to examine the influence of fat-free mass (FFM) on age-related differences in strength in young club (8-13 years) and high-school (14-18 years) wrestlers. The dependent variables were log-transformed values of isokinetic peak torque for leg extension and flexion at 0.

Effects of ipsilateral anterior thigh soft tissue stretching on passive unilateral straight-leg raise.

Study Design: Randomized 3-group pretest-posttest with blind assessment of outcome.

Objectives: The purpose of this study was to examine the effect of sagittal plane hold-relax exercise applied to the ipsilateral anterior thigh, and prone positioning on passive unilateral straight-leg raise measurements.

Background: Straight-leg raising has been viewed as a measurement for hamstring muscle length, but literature suggests that other structures may affect this measurement.

Effect of fatigue on hamstring coactivation during isokinetic knee extensions.

We examined the effect of fatigue of the quadriceps muscles on coactivation of the hamstring muscles and determined if the response is different between two isokinetic speeds in ten males and ten females with no history of knee pathology. Electromyographic data were recorded from the vastus lateralis and biceps femoris muscles during 50 maximal knee extensions at isokinetic speeds of 1.75 rad x s(-1) (100 degrees x s(-1)) and 4.

1998 William J. Stickel Gold Award. The effects of extrinsic muscle forces on the forefoot-to-rearfoot loading relationship in vitro. Tibia and Achilles tendon.

The effects of muscular activity on the distribution of forces under the foot, as well as within the foot, are of great importance for determining the mechanisms of foot pathologies. Limited data exist concerning muscle forces during the gait cycle and the effects of muscle forces conveyed to the ground-reactive forces of the foot. The authors developed a cadaveric loading system to determine the effects of force applied to the Achilles tendon on the forefoot-to-rearfoot loading relationship in eight cadaveric specimens.

Comparison of mitosis in binucleated and mononucleated newt cardiac myocytes.

Background: The cultured adult newt ventricular myocyte has been shown to undergo mitosis and cytokinesis in a fully differentiated state. Insight into its proliferation and cellular changes during the repair process involves obtaining a better understanding of the nuclear pattern (mononucleated, binucleated, or multinucleated) resulting from mitotic events. Mitosis is easily observable in cultured newt cardiac myocytes using phase-contrast microscopy.

An Engelhardtian analysis of interactions between pharmaceutical sales representatives and physicians.

Physician conflict of interest has been of concern since Hippocrates and rarely is this concern more evident than in the relationship between pharmaceutical sales representatives (PSR) and physicians. Given the acrimonious public debates concerning this issue a careful exploration of the concerns at sake and the conceptual arguments which support such concerns is called for. In this piece I will take as heuristic the conceptual philosophical framework argued for by H.

The effect of unilateral concentric weight training and detraining on joint angle specificity, cross-training, and the bilateral deficit.

Changes in strength following concentric-only weight training and detraining are poorly understood. The purpose of this investigation was to examine the effects of unilateral concentric leg extension weight training and detraining on joint angle specificity, cross-training, and the bilateral deficit (individual limb strength > bilateral strength/2). Sixteen males volunteered to be subjects for this investigation (concentric training group, N = 8; control group, N = 8).

Study of ten anatomical variants of the foot and ankle.

This study examined the occurrence rate of ten lower extremity anatomical variants occurring over a 6-year period from 1988 to 1994 in a sample range of 166 to 279 cadavers at the University of Osteopathic Medicine and Health Sciences. Literature review of these anomalies shows similar findings for all presented structures with the exception of two. The peroneus quartus muscle was found to be significantly less prevalent than previous studies have indicated.

The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.

Direct evidence that N-acetylcysteine (NAC) enhances the immune response of peripheral blood T cells at the level of NF(kappa)B is presented. In addition, NAC blocks the suppression of T cell mitogenesis and cytokine production by protease inhibitors such as N-tosylphenylalanine chloromethyl ketone (TPCK). The proliferative responses of purified CD4+ or CD8+ T cells are suppressed more strongly by TPCK when anti-CD28 rather than the phorbol ester PMA is used as the mitogenic coactivator.

Functional motion of the medial column joints of the foot during propulsion.

Motion in the ankle, subtalar, midtarsal, and first metatarsophalangeal joints has been well documented. However, motion in the first metatarsocuneiform, the first cuneonavicular, and the first interphalangeal joint has not been addressed. Motion in these joints has not been documented because many believe that little motion occurs at these joints, and because of the difficulty in assessing motion at these joints.

The effect of extraneous movements on peak torque and constant joint angle torque-velocity curves.

During isokinetic knee testing, some subjects flex the trunk and contralateral knee during knee extension and the trunk and contralateral knee during knee flexion. This investigation assessed the effect of these extraneous movements on peak and constant joint angle torque (15 degrees below horizontal). Twenty-one subjects performed isokinetic knee extensions and flexions at 60, 180, and 300 degrees/sec under stabilized and nonstabilized conditions.

The effects of joint angle on electromyographic indices of fatigue.

The purpose of this study was to examine the effect of manipulation of joint angle on electromyographic (EMG) fatigue curves at different sites over the quadriceps muscle group. Eight subjects performed isometric knee extensions at 0.26, 0.

The effect of unilateral eccentric weight training and detraining on joint angle specificity, cross-training, and the bilateral deficit.

Eccentric resistance training is an important component of many rehabilitation protocols. The adaptations following eccentric training are poorly understood in relation to concentric training. The purpose of this investigation was to examine the effects of unilateral eccentric leg extension weight training and detraining on joint angle specificity, cross-training, and the bilateral deficit.

Motile Aeromonas as agent of infections of the foot.

Motile Aeromonas infections of the foot are caused mostly by post-traumatic incidence, occurring mostly during summer months. Serious complications such as osteomyelitis and amputation can result if the infections go untreated or are inadequately treated. The role of each species of motile Aeromonas in pathogenesis and response to antimicrobial agents is not well understood because of taxonomic uncertainty.

Chromoblastomycosis. A fungal infection primarily observed in the lower extremity.

Chromoblastomycosis is a cutaneous-subcutaneous fungal infection that is being seen more frequently in patients living in the US. The disease normally occurs in patients living in tropical and subtropical regions, but as the number of immigrants into the US increases, podiatrists must be able to recognize the manifestations of chromoblastomycosis. The most common sight involved is the lower extremity where it easily can be confused with other diseases such as tertiary syphilis, phaeohyphomycosis, and cutaneous tuberculosis, among others.

A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome.

The authors review the etiologies and treatments of plantar fasciitis or heel spur syndrome. They offer results of a retrospective study. Comparison of the return to work time after surgery for this condition, examinations of the effects of patient age at the time of surgery, gender, duration of pain prior to surgery, and type of surgical procedure, either endoscopic plantar fasciotomy or open plantar fasciotomy with heel spur resection, is provided.

The Syme's amputation: a correlation of surgical technique and prosthetic management with an historical perspective.

In 1843, James Syme introduced an amputation which he believed had numerous advantages over more proximal amputations. Despite these claims, utilization of the Syme's amputation has been limited due to a less than ideal compatibility of the surgical result with prosthetic design and function. In this article, the history of the Syme's amputation is reviewed along with indications and surgical technique.

Endoscopic carpal tunnel release.

Conventional open carpal tunnel release effectively relieves symptoms, but involves pain and fairly long recovery time. A relatively new technique of endoscopic carpal tunnel release as described by Chow has been carried out on 20 hands in 16 patients. The endoscopic approach allows earlier return to normal activities with less postoperative pain than conventional or open release.