1,673 results match your criteria: "University of Orléans and CNRS[Affiliation]"

Developmental origins of natural sound perception.

Front Psychol

December 2024

Laboratoire des Systèmes Perceptifs, UMR CNRS 8248, Ecole Normale Supérieure, PSL University, Paris, France.

Infants are exposed to a myriad of sounds early in life, including caregivers' speech, songs, human-made and natural (non-anthropogenic) environmental sounds. While decades of research have established that infants have sophisticated perceptual abilities to process speech, less is known about how they perceive natural environmental sounds. This review synthesizes current findings about the perception of natural environmental sounds in the first years of life, emphasizing their role in auditory development and describing how these studies contribute to the emerging field of human auditory ecology.

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We investigate the driven-dissipative dynamics of multilevel atomic arrays interacting via dipolar interactions at subwavelength spacings. Unlike two-level atoms in the weakly excited regime, multilevel atoms can become strongly entangled. The entanglement manifests as the growth of spin waves in the ground-state manifold and survives after turning off the drive.

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Structure of the aminoterminal domain of the birnaviral multifunctional VP3 protein and its unexplored critical role.

PNAS Nexus

December 2024

Institut de Biologia Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Baldiri i Reixac 15, 08028 Barcelona, Spain.

To overcome their limited genetic capacity, numerous viruses encode multifunctional proteins. The birnavirus VP3 protein plays key roles during infection, including scaffolding of the viral capsid during morphogenesis, recruitment, and regulation of the viral RNA polymerase, shielding of the double-stranded RNA genome and targeting of host endosomes for genome replication, and immune evasion. The dimeric form of VP3 is critical for these functions.

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Continuous Quasi-Attractors dissolve with too much - or too little - variability.

PNAS Nexus

December 2024

SISSA, Scuola Internazionale Superiore di Studi Avanzati, Cognitive Neuroscience, Trieste 34136, Italy.

Recent research involving bats flying in long tunnels has confirmed that hippocampal place cells can be active at multiple locations, with considerable variability in place field size and peak rate. With self-organizing recurrent networks, variability implies inhomogeneity in the synaptic weights, impeding the establishment of a continuous manifold of fixed points. Are continuous attractor neural networks still valid models for understanding spatial memory in the hippocampus, given such variability? Here, we ask what are the noise limits, in terms of an experimentally inspired parametrization of the irregularity of a single map, beyond which the notion of continuous attractor is no longer relevant.

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Synthesis of cerium yldiide complexes and their reactivity with CO is demonstrated. In the case of the sulphur-tethered yldiide, the ketenyl complex is formed with release of PPh, while PhPCCO is formed along with a sulfinato ligand in the case of the tosyl-substituted yldiide. Computational analysis shows that this diverging reactivity is due to the stability of the two isomers in the first step of each mechanism.

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Article Synopsis
  • The study investigates the synthesis of nitrogen-doped carbon nanotubes (N-CNTs) using graphitic carbon nitride (g-C3N4) etching facilitated by nickel nanoparticles, highlighting innovative methods in nanotechnology.
  • Concerns are raised regarding the growth processes and the implications for the quality and characteristics of the resulting N-CNTs, which are significant for various applications in electronics and materials science.
  • The article emphasizes the need for further research to optimize the etching process and understand the interactions between g-C3N4 and nickel nanoparticles for better control over N-CNT synthesis.
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Entanglement and Mutual Information in Molecules: Comparing Localized and Delocalized Orbitals.

J Chem Theory Comput

December 2024

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Borsari 76, I-44121 Ferrara, Italy.

The use of the mutual information (MI) as a measure of the entanglement in quantum systems has gained a consensus in recent years, even if there is an ongoing effort to distinguish the classical and quantum contributions contained therein. This quantity has been first introduced in condensed matter physics, in particular, in studies based on the density matrix renormalization group method. This method has been successfully adapted to quantum chemistry problems, opening the way to compute MI also in molecular systems.

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Many biological and medical questions can be modeled using time-to-event data in finite-state Markov chains, with the phase-type distribution describing intervals between events. We solve the inverse problem: given a phase-type distribution, can we identify the transition rate parameters of the underlying Markov chain? For a specific class of solvable Markov models, we show this problem has a unique solution up to finite symmetry transformations, and we outline a recursive method for computing symbolic solutions for these models across any number of states. Using the Thomas decomposition technique from computer algebra, we further provide symbolic solutions for any model.

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Article Synopsis
  • EpCAM and Trop2 are cell surface markers linked to carcinoma, affecting myosin-based cell behaviors essential for adhesion and migration, but their specific roles in cancer metastasis are not well understood.
  • The study uses MCF7 breast cancer cell spheroids to explore how different levels of EpCAM and Trop2 influence cell spreading and cohesion, revealing that depleting EpCAM promotes spreading while depleting Trop2 inhibits it.
  • The findings suggest that EpCAM and Trop2 work together to regulate cell contractility and adhesion by affecting cortical tension at cell interfaces, indicating their potential function as a mechanostat that modulates cell behavior in cancer progression.
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Separable Hamiltonian neural networks.

Phys Rev E

October 2024

School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417 and CNRS International Research Laboratory 2955 on Artificial Intelligence, Singapore 138632.

Hamiltonian neural networks (HNNs) are state-of-the-art models that regress the vector field of a dynamical system under the learning bias of Hamilton's equations. A recent observation is that embedding a bias regarding the additive separability of the Hamiltonian reduces the regression complexity and improves regression performance. We propose separable HNNs that embed additive separability within HNNs using observational, learning, and inductive biases.

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Article Synopsis
  • Photodynamic therapy (PDT) is gaining attention for potentially reducing chemotherapy side effects and enhancing patients’ quality of life, but many PDT drugs struggle with poor absorption and effectiveness.
  • This article examines a specific PDT drug, temoporfin (Foscan), combined with β-cyclodextrin units as carriers to improve its delivery to cells.
  • All-atom simulations demonstrate that the drug complex can penetrate lipid membranes and may dissociate within, supporting the idea that this method could enhance drug efficacy in PDT applications.
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Objectives: While some metals have been reported as carcinogens or potential carcinogens, only few modern-standard datasets including a large number of elements are available. The present analysis established a first trace elements spectrum by relating the concentration of metals and trace elements in the serum of sarcoma patients with survival data.

Methods: Patients with sarcoma and controls were retrospectively selected from the International Sarcoma Kindred Study database (ISKS).

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Article Synopsis
  • Hybrid systems combining graphene with organic molecules are promising for enhancing the optoelectronic properties of 2D materials, but the connection between the structure of the organic molecules and the performance of these hybrids is not fully understood.
  • The study focuses on a molecular design technique called "peripheral editing," which helps clarify how different molecular structures affect their interaction with graphene in hybrid systems.
  • The researchers found that using tetrathiafulvalene molecules enhances charge transfer in graphene, resulting in highly efficient photodetectors that outperform existing graphene-based devices, highlighting important strategies for future improvements in this technology.
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  • Researchers are investigating whether activating the STING pathway causes lung inflammation that resembles severe asthma, particularly by focusing on neutrophilic responses.
  • They developed models using house dust mites and STING agonists to study inflammation effects on mice and human cells, measuring various inflammatory markers and lung function.
  • The findings suggest that STING activation leads to increased airway hyperresponsiveness and cell death, resembling severe asthma features and indicating a mixed immune response involving type 1 neutrophils.
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Chirality and odd mechanics in active columnar phases.

PNAS Nexus

October 2024

Centre for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore, Karnataka 560 012, India.

Chiral active materials display odd dynamical effects in both their elastic and viscous responses. We show that the most symmetric mesophase with 2D odd elasticity in three dimensions is chiral, polar, and columnar, with 2D translational order in the plane perpendicular to the columns and no elastic restoring force for their relative sliding. We derive its hydrodynamic equations from those of a chiral active variant of model H.

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Exerting a nonequilibrium drive on an otherwise equilibrium Langevin process brings the dynamics out of equilibrium but can also speed up the approach to the Boltzmann steady state. Transverse forces are a minimal framework to achieve dynamical acceleration of the Boltzmann sampling. We consider a simple liquid in three space dimensions subjected to additional transverse pairwise forces, and quantify the extent to which transverse forces accelerate the dynamics.

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Genome-wide studies define new genetic mechanisms of IgA vasculitis.

medRxiv

October 2024

Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.

Article Synopsis
  • IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.* -
  • Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.* -
  • Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
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Palmatine is a protoberberine alkaloid, which may produce singlet oxygen under visible light irradiation and binds to DNA. The fact that singlet oxygen activation in palmatine may be triggered by environmental conditions, and in particular its interaction with nucleic acids, makes it a most suitable candidate for photodynamic therapy and DNA-targeted noninvasive anticancer strategies. Despite these remarkable properties, the actual binding mode between palmatine and DNA has not been resolved, yet.

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Many-particle entanglement is a key resource for achieving the fundamental precision limits of a quantum sensor. Optical atomic clocks, the current state of the art in frequency precision, are a rapidly emerging area of focus for entanglement-enhanced metrology. Augmenting tweezer-based clocks featuring microscopic control and detection with the high-fidelity entangling gates developed for atom-array information processing offers a promising route towards making use of highly entangled quantum states for improved optical clocks.

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Among a broad diversity of color centers hosted in layered van der Waals materials, the negatively charged boron vacancy (V) center in hexagonal boron nitride (hBN) is garnering considerable attention for the development of quantum sensing units on a two-dimensional platform. In this work, we investigate how the optical response of an ensemble of V centers evolves with the hBN thickness in a range of a few to hundreds of nanometers. We show that the photoluminescence intensity features a nontrivial evolution with thickness, which is quantitatively reproduced by numerical calculations taking into account thickness-dependent variations of the absorption, radiative lifetime, and radiation pattern of V centers.

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Dog-human vocal interactions match dogs' sensory-motor tuning.

PLoS Biol

October 2024

Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Article Synopsis
  • Within species, vocal and auditory systems have evolved to optimize sound production and perception for communication, and this study investigates how dogs fit into this framework despite their inability to produce spoken words.
  • The acoustic analysis indicates that dog vocalizations have a slower rhythm than human syllabic speech, with human-directed speech falling in between the two.
  • The research demonstrates that dogs comprehend speech through a slower rhythm tracking (delta) compared to humans (theta), suggesting humans might adjust their speech rate to enhance communication with dogs.
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Large-scale simulations of light-matter interaction in natural photosynthetic antenna complexes containing more than one hundred thousands of chlorophyll molecules, comparable with natural size, have been performed. Photosynthetic antenna complexes present in Green sulfur bacteria and Purple bacteria have been analyzed using a radiative non-Hermitian Hamiltonian, well-known in the field of quantum optics, instead of the widely used dipole-dipole Frenkel Hamiltonian. This approach allows us to study ensembles of emitters beyond the small volume limit (system size much smaller than the absorbed wavelength), where the Frenkel Hamiltonian fails.

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Epileptic variant in the spectrum of Alzheimer's disease - practical implications.

Seizure

September 2024

Centre Mémoire, de Ressources et de Recherche de Strasbourg, France; Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), team IMIS/Neurocrypto Strasbourg, France; Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg, France. Electronic address:

Article Synopsis
  • Alzheimer's disease (AD) is linked to a higher risk of epilepsy, not only in its advanced stages (dementia) but also during earlier phases like mild cognitive impairment.
  • Epileptic seizures can even appear in the preclinical stage of AD, leading to a specific condition called the epileptic variant of Alzheimer's disease (evAD), which may be the only visible sign of the disease at that time.
  • Diagnosing evAD relies on examining amyloid and tau biomarkers and represents a crucial opportunity for early intervention with antiseizure medications to help slow down cognitive decline associated with AD.
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One-dimensional Bose gases with contact repulsive interactions are characterized by the presence of infinite-lifetime quasiparticles whose momenta are called the "rapidities." Here, we develop a probe of the local rapidity distribution, based on the fact that rapidities are the asymptotic momenta of the particles after a long one-dimensional expansion. This is done by performing an expansion of a selected slice of the gas.

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The order of stimuli within sequences and the transitional probabilities (TPs) it generates are central information in sequence processing. However, less is known about what type of information and how it is extracted by general learning mechanisms. The present study focused on statistical learning of second-order TPs.

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