Dramatic evolution of body length due to postembryonic changes in cell size in a newly discovered close relative of .

Understanding morphological diversity-and morphological constraint-has been a central question in evolutionary biology since its inception. Nematodes of the genus , which contains the well-studied model organism , display remarkable morphological consistency in the face of extensive genetic divergence. Here, we provide a description of the broad developmental patterns of a newly discovered species, .

Ancient genomic variation underlies repeated ecological adaptation in young stickleback populations.

Adaptation in the wild often involves standing genetic variation (SGV), which allows rapid responses to selection on ecological timescales. However, we still know little about how the evolutionary histories and genomic distributions of SGV influence local adaptation in natural populations. Here, we address this knowledge gap using the threespine stickleback fish () as a model.

Patient-provider relationship and perceived provider weight bias among American Indians and Alaska Natives.

Objective: The objective of this study was to examine patient-provider relationships among American Indians and Alaska Native (AI/AN) patients by examining associations between patient activation, perceived provider weight bias and working alliance. Patient activation is generally defined as having the knowledge, skills and confidence to manage one's health.

Methods: Among a sample of 87 AI/AN adults presenting for general medical care at an urban clinic in the north-west region of the USA, ordinary least squares regression analysis was completed to examine associations.

Underlying causes of Eurasian midcontinental aridity in simulations of mid-Holocene climate.

Climate model simulations uniformly show drier and warmer summers in the Eurasian midcontinent during the mid-Holocene, which is not consistent with paleoenvironmental observations. The simulated climate results from a reduction in the zonal temperature gradient, which weakens westerly flow and reduces moisture flux and precipitation in the midcontinent. As a result, sensible heating is favored over evaporation and latent heating, resulting in substantial surface-driven atmospheric warming.

Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin.

Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure.

Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence.

Introduction: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocampus. However, the hippocampus is a functionally and structurally heterogeneous region, and little is known about how maltreatment might affect hippocampal subregion development throughout important periods of plasticity. This study investigated whether childhood maltreatment was associated with the development of hippocampal subregion volumes from early to late adolescence.

Redundant Postsynaptic Functions of SynCAMs 1-3 during Synapse Formation.

Investigating the roles of synaptogenic adhesion molecules during synapse formation has proven challenging, often due to compensatory functions between additional family members. The synaptic cell adhesion molecules 1-3 (SynCAM1-3) are expressed both pre- and postsynaptically, share highly homologous domains and are synaptogenic when ectopically presented to neurons; yet their endogenous functions during synaptogenesis are unclear. Here we report that SynCAM1-3 are functionally redundant and collectively necessary for synapse formation in cultured hippocampal neurons.

Influence of the SLC6A3-DAT1 Gene on Multifaceted Measures of Self-regulation in Preschool Children.

Development of self-regulation, the capacity to voluntarily modulate thoughts, emotions and actions is strongly related to the maturation of the dopamine-mediated executive attention network (EAN). The attention control processes associated with the EAN greatly overlap with efficiency of the executive functions and are correlated with measures of effortful control. Regulation of dopamine levels within the EAN, particularly in the basal ganglia is carried out by the action of dopamine transporters.

Thermodynamic and Kinetic Response of Microbial Reactions to High CO.

Geological carbon sequestration captures CO from industrial sources and stores the CO in subsurface reservoirs, a viable strategy for mitigating global climate change. In assessing the environmental impact of the strategy, a key question is how microbial reactions respond to the elevated CO concentration. This study uses biogeochemical modeling to explore the influence of CO on the thermodynamics and kinetics of common microbial reactions in subsurface environments, including syntrophic oxidation, iron reduction, sulfate reduction, and methanogenesis.

Electrocortical Sources Related to Whole-Body Surface Translations during a Single- and Dual-Task Paradigm.

Appropriate reactive motor responses are essential in maintaining upright balance. However, little is known regarding the potential location of cortical sources that are related to the onset of a perturbation during single- and dual-task paradigms. The purpose of this study was to estimate the location of cortical sources in response to a whole-body surface translation and whether diverted attention decreases the N1 event-related potential (ERP) amplitude related to a postural perturbation.

Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits.

Cortical inhibitory neurons exhibit remarkable diversity in their morphology, connectivity, and synaptic properties. Here, we review the function of somatostatin-expressing (SOM) inhibitory interneurons, focusing largely on sensory cortex. SOM neurons also comprise a number of subpopulations that can be distinguished by their morphology, input and output connectivity, laminar location, firing properties, and expression of molecular markers.

Beyond Mg: functional interactions between RNA and transition metals.

It is well-known that RNA structure and function depend heavily on cations, and the ability of Mg to stabilize RNA structures has been emphasized. Recent studies, however, highlight the importance of transition metals in RNA function. Riboswitches that selectively bind Ni, Co, and Mn have been discovered with specific RNA-metal sites that influence metal-related gene expression.

MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b.

Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequent failure of NCC patterning and differentiation into bone and cartilage. While loss of gene expression is often associated with developmental defects, aberrant upregulation of expression can also be detrimental.

Taxonomy of Individual Variations in Aesthetic Responses to Fractal Patterns.

In two experiments, we investigate group and individual preferences in a range of different types of patterns with varying fractal-like scaling characteristics. In Experiment 1, we used 1/f filtered grayscale images as well as their thresholded (black and white) and edges only counterparts. Separate groups of observers viewed different types of images varying in slope of their amplitude spectra.

A Complex Story: Universal Preference vs. Individual Differences Shaping Aesthetic Response to Fractals Patterns.

Fractal patterns offer one way to represent the rough complexity of the natural world. Whilst they dominate many of our visual experiences in nature, little large-scale perceptual research has been done to explore how we respond aesthetically to these patterns. Previous research (Taylor et al.

Aesthetic Responses to Exact Fractals Driven by Physical Complexity.

Fractals are physically complex due to their repetition of patterns at multiple size scales. Whereas the statistical characteristics of the patterns repeat for fractals found in natural objects, computers can generate patterns that repeat exactly. Are these exact fractals processed differently, visually and aesthetically, than their statistical counterparts? We investigated the human aesthetic response to the complexity of exact fractals by manipulating fractal dimensionality, symmetry, recursion, and the number of segments in the generator.

Beyond Mg(2+): functional interactions between RNA and transition metals.

It is well-known that RNA structure and function depend heavily on cations, and the ability of Mg(2+) to stabilize RNA structures has been emphasized. Recent studies, however, highlight the importance of transition metals in RNA function. Riboswitches that selectively bind Ni(2+), Co(2+), and Mn(2+) have been discovered with specific RNA-metal sites that influence metal-related gene expression.

Guidelines for the functional annotation of microRNAs using the Gene Ontology.

MicroRNA regulation of developmental and cellular processes is a relatively new field of study, and the available research data have not been organized to enable its inclusion in pathway and network analysis tools. The association of gene products with terms from the Gene Ontology is an effective method to analyze functional data, but until recently there has been no substantial effort dedicated to applying Gene Ontology terms to microRNAs. Consequently, when performing functional analysis of microRNA data sets, researchers have had to rely instead on the functional annotations associated with the genes encoding microRNA targets.

Characteristics of Eye-Position Gain Field Populations Determine Geometry of Visual Space.

We have previously demonstrated differences in eye-position spatial maps for anterior inferotemporal cortex (AIT) in the ventral stream and lateral intraparietal cortex (LIP) in the dorsal stream, based on population decoding of gaze angle modulations of neural visual responses (i.e., eye-position gain fields).

Oligothiophene wires: impact of torsional conformation on the electronic structure.

Charge transport in polymer- and oligomer-based semiconductor materials depends strongly on the structural ordering of the constituent molecules. Variations in molecular conformations influence the electronic structures of polymers and oligomers, and thus impact their charge-transport properties. In this study, we used Scanning Tunneling Microscopy and Spectroscopy (STM/STS) to investigate the electronic structures of different alkyl-substituted oligothiophenes displaying varied torsional conformations on the Au(111) surface.

eHealth for Patient Engagement: A Systematic Review.

eHealth interventions are recognized to have a tremendous potential to promote patient engagement. To date, the majority of studies examine the efficacy of eHealth in enhancing clinical outcomes without focusing on patient engagement in its specificity. This paper aimed at reviewing findings from the literature about the use of eHealth in engaging patients in their own care process.

AltitudeOmics: Resetting of Cerebrovascular CO2 Reactivity Following Acclimatization to High Altitude.

Previous studies reported enhanced cerebrovascular CO2 reactivity upon ascent to high altitude using linear models. However, there is evidence that this response may be sigmoidal in nature. Moreover, it was speculated that these changes at high altitude are mediated by alterations in acid-base buffering.