15,172 results match your criteria: "University of Oklahoma Health Sciences[Affiliation]"
Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes.
Nicotine Tob Res
November 2024
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.
Introduction: This study applied a novel tobacco regulatory science paradigm to characterize inter-product variation in the appeal and sensory features of emerging commercial and therapeutic oral nicotine products (ONPs) among young adults that vape e-cigarettes.
Methods: Twenty-three young adults without ONP experience who use e-cigarettes completed a single-blind, single-visit remote lab study. Participants rated appeal and sensory characteristics during 5-minute standardized self-administrations of 8 ONPs (4 fruit, 4 mint) from various brands (Lucy, Rouge, Solace, Nicorette, On!, Velo).
Integrating patient advocacy groups in the development of clinical practice guidelines: comment on the article by Johnson et al.
Arthritis Care Res (Hoboken)
November 2024
Sjögren's Foundation, Reston, Virginia.
Implementation mapping to plan for the Supraglottic Airway for Resuscitation (SUGAR) trial.
Implement Sci Commun
November 2024
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Positive pressure ventilation (PPV) is an essential component of neonatal resuscitation. Meta-analytic evidence suggests that, among late preterm and term newborn infants who require resuscitation after birth, a supraglottic airway (SA) device is more effective than a face mask at reducing the probability of PPV failure and reducing the need for endotracheal intubation. However, SA devices are rarely used in routine practice in hospital delivery room settings within the United States.
View Article and Find Full Text PDFAdvancing prediction of age-related vascular cognitive impairment based on peripheral and retinal vascular health in a pilot study: a novel comprehensive assessment developed for a prospective workplace-based cohort (The Semmelweis Study).
Geroscience
November 2024
Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Article Synopsis
- The Semmelweis Study in Hungary aims to address the public health challenges of unhealthy aging in the EU by examining the factors that contribute to age-related diseases, particularly vascular cognitive impairment (VCI).
- The pilot study involved 49 participants aged 23 to 87, assessing cognitive performance and vascular health through various advanced imaging techniques and tests.
- The analysis showed a correlation between vascular health indices, age, and cognitive performance, suggesting that a better understanding of this relationship could lead to new insights on healthy aging.
Intraoperative Frontal EEG Alpha Power is Associated with Post-Operative Mortality and Other Adverse Outcomes.
Anesthesiology
November 2024
Department of Anesthesia, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Article Synopsis
- A study analyzing intraoperative EEG data from 1,081 patients found that higher alpha power (8-12Hz) during surgery is associated with lower post-operative mortality and better cognitive outcomes.
- The research indicated significant correlations between alpha power and mortality within various time frames: 30, 90, 180 days, and 1 year post-surgery.
- These findings suggest that measuring intraoperative EEG alpha power could be a valuable tool for predicting patient outcomes and improving perioperative risk assessment.
The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti- activity and in a treatment model of fungal keratitis.
Front Cell Infect Microbiol
November 2024
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Objective: The fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that is essential for virulence in a murine model of fungal keratitis (FK), suggesting the pathway could serve as a therapeutic target. Here we investigate the antifungal properties of known inhibitors of the mammalian Ire1 protein both and in a treatment model of FK.
View Article and Find Full Text PDFCardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report.
AJP Rep
July 2024
Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa.
Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile.
View Article and Find Full Text PDFCorneal Treatment, Repair, and Regeneration: Exosomes at Rescue.
Pharmaceutics
November 2024
Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Exosomes are extracellular vesicles within the nanosized range that play roles in intercellular communication and thus have certain biological activities. The secretory signaling communication mechanism is an efficient way of exchanging information between cells and has been investigated as nature's therapeutic drug carriers. This review will summarize the potential of exosomes as therapeutic tools and drug delivery vehicles for corneal pathologies.
View Article and Find Full Text PDFLong-term perioperative antibiotic prophylaxis after urethral reconstruction does not improve clinical outcomes and increases incidence of MDR organisms.
World J Urol
November 2024
Department of Urology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd, WP 2140, Oklahoma City, Oklahoma, 73104, USA.
Article Synopsis
- The study examined the effects of long-term postoperative antibiotic use after urethral reconstruction on patient outcomes and the development of multidrug-resistant bacteria.
- It involved a retrospective analysis of 147 patients, comparing those who received antibiotic prophylaxis to those who did not, and found that antibiotic use was linked to a higher presence of multidrug-resistant bacteria in urine cultures.
- Ultimately, the findings suggest that while prophylactic antibiotics do not improve surgical recovery outcomes, they increase the risk of antibiotic resistance, advising against their routine use in such procedures.
Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer.
J Med Virol
November 2024
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Article Synopsis
- * The study found that the heat shock protein HSP70 binds specifically to the E7 oncoprotein, and an investigational drug, SHetA2, disrupts this binding.
- * Treatment with SHetA2 led to lower levels of E6 and E7 mRNA and protein, altered cell cycle proteins, and decreased cancer cell growth, indicating its potential as a new therapy for cervical cancer.
Historical Perspective of Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma.
Acta Haematol
November 2024
Department of Hematology and Oncology/Stem Cell Transplantation, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA.
Background: Advances in novel therapies have improved outcomes for multiple myeloma (MM) patients and the use of allo-SCT has decreased. Current guidelines no longer support allo-SCT as consolidation therapy for newly diagnosed MM, even in high-risk cases.
Summary: Allo-SCT is now typically considered only within clinical trials for young, high-risk patients with relapsed or refractory MM (RRMM).
Atypical delayed ventriculoperitoneal shunt infection following hysteroscopic polypectomy: illustrative case.
J Neurosurg Case Lessons
November 2024
Departments of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Article Synopsis
- A 36-year-old woman with a history of congenital hydrocephalus experienced complications from her VP shunt, including an infected abdominal incision with no recent infection risks other than a minor gynecological procedure.
- Cultures revealed unusual bacteria, leading to the externalization and eventual removal of her shunt, alongside a course of intravenous and oral antibiotics, which successfully healed the infection.
- The case highlights the need for thorough investigation of infections in shunt patients, even when they present atypically or outside the standard timeframe for infections.
Adults perceive similar ultra-processed and minimally processed foods as having different levels of healthfulness: Development of stimuli for an ultra-processed food-related implicit association task.
Nutr Health
November 2024
TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Ultra-processed food (UPF) consumption is excessive across the United States (US). Understanding perceptions of food based on processing is critical to elucidate reasons for UPF intake and inform tool development for measuring related cognition. Design and evaluate perceptions of UPF and non-UPF food among general US adults.
View Article and Find Full Text PDFSerum adropin is unaltered in adolescents with histology-confirmed steatotic liver disease.
J Pediatr Gastroenterol Nutr
January 2025
Section of Diabetes/Endocrinology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Article Synopsis
- Recent research indicates that adropin levels in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD) were not lower than those in adolescents with obesity or normal weight, contrary to previous studies.
- Adropin levels were found to be 5% to 20% higher in adolescents with MASLD compared to obesity and normal weight controls, and also showed a significant difference between boys and girls.
- Additionally, while adropin levels were positively correlated with age in the MASLD group, they did not correlate with arterial stiffness or blood pressure, suggesting a more complex relationship with this liver-derived peptide that requires further study.
Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings.
PNAS Nexus
November 2024
Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK 73104, USA.
Article Synopsis
Optimizing lncRNA-miRNA interaction analysis: Modified crosslinking and immunoprecipitation (M-CLIP) assay.
MethodsX
December 2024
Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Article Synopsis
- Understanding lncRNA-miRNA interactions is important for cellular signaling and cancer studies, particularly in how the long non-coding RNA (lncRNA) UCA1 impacts ovarian cancer through its relationship with let-7 miRNAs.* -
- The research posits that UCA1 functions as a competing endogenous RNA (ceRNA), sequestering let-7 miRNAs to influence the expression of their target genes, which can lead to increased cancer progression.* -
- A new technique called Modified Crosslinking and Immunoprecipitation (M-CLIP) was developed to effectively capture these interactions, confirming that UCA1 binds with let-7 miRNAs and could potentially reveal new insights into cancer progression mechanisms
Incidence of anaphylaxis in patients with alpha-gal syndrome receiving gelatin-containing vaccines: A large database analysis.
J Allergy Clin Immunol Pract
November 2024
Department of Medicine, Section of Infectious Diseases Section, University of Oklahoma Health Sciences Center, Oklahoma City, Okla; Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal, Tegucigalpa, Honduras.
Article Synopsis
- * Data was collected from a national sample of 4,091 young adults (18-34) and analyzed using logistic regression to explore the relationship between neighborhood racial/ethnic and economic segregation and smoking behavior.
- * Results revealed that residents in areas with higher concentrations of Hispanic/Latino and Black individuals had increased smoking risks, especially when compared to those in wealthier, predominantly White neighborhoods, highlighting the need for targeted tobacco reduction interventions.
Attachment & biobehavioral catch-up participation & reunification in a family treatment court.
Child Abuse Negl
December 2024
University of Kansas School of Medicine, 3901 Rainbow Blvd., Kansas City, Kansas, 66103, USA.
Article Synopsis
- Children affected by substance use disorders (SUD) are more likely to enter child welfare systems, and effective interventions should focus on the entire family unit rather than just the individual suffering from SUD.* -
- This study explored the link between participation in the Attachment and Biobehavioral Catch-Up (ABC) model and the rates of family reunification in cases involving substance use disorders within family treatment courts.* -
- Results indicated that 74% of children involved in the ABC model were reunified with their biological parents, compared to 57% of those not exposed; biological parent participation significantly increased the likelihood of reunification.*
Corrigendum to "Inhibition of Pancreatic Intraepithelial Neoplasia Progression to Carcinoma by Nitric Oxide-Releasing Aspirin in p48Cre/+-LSL-KrasG12D/+ Mice" [Neoplasia, Volume 14, Issue 9 (2012) 778-787].
Neoplasia
January 2025
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD.
Osimertinib for Uncommon Endothelial Growth Factor Receptor-Mutant Non-Small Cell Lung Carcinoma: A Case Report.
Case Rep Oncol
November 2024
Division of Hematology and Oncology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Article Synopsis
- Non-small cell lung cancer (NSCLC) is the most common lung cancer type, responsible for a majority of cancer deaths globally, and advancements in treatments, especially targeted therapies like osimertinib, have improved management options.
- Osimertinib, a third-generation tyrosine kinase inhibitor, effectively targets specific mutations in the EGFR gene, including rare mutations, as exemplified by a 64-year-old woman whose unique exon 19 mutation responded well to the drug, leading to 26 months of disease control.
- The study highlights the limited research available for rare EGFR mutations and emphasizes the need for further prospective studies to better understand treatment responses and ensure safe and effective therapies for this patient group.
The Computational Tools to Identify DNA Repeats and Motifs: A Systematic Review.
Curr Top Med Chem
November 2024
Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma-73104, USA.
Article Synopsis
- - The article focuses on DNA repeats and motifs, which are crucial nucleotide patterns in genomes linked to gene regulation, genomic instability, and various diseases, making their identification essential for research.
- - It reviews about 200 computational tools and databases used for detecting DNA repeats and motifs, offering insights into their accuracy and popularity based on citation metrics to aid users in selecting the best options for their research.
- - Utilizing a structured literature review process, the study analyzed 3,233 publications and narrowed it down to 200 that met criteria for studying DNA repeats and motifs, categorizing them into tools for repeat prediction, regulatory element databases, and motif prediction.
Elucidation of fibrinolysis in pregnant women. One size does not fit all - Letter in response to "Variability of fibrinolytic activity in pregnant patients exposed to tissue plasminogen activator: An in vitro study utilizing rotational thromboelastometry".
Int J Obstet Anesth
September 2024
Department of Anesthesiology, University of Oklahoma Health Sciences Center, USA. Electronic address:
American Society of Hematology: building a comprehensive minority recruitment and retention professional program.
Blood Adv
December 2024
Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Article Synopsis
- * Between 2004 and 2022, MRI awarded scholarships to 405 individuals, and those who received funding had significantly lower dropout rates compared to national averages: 0% for graduate students and 2.2% for medical students.
- * The initiative also showed that awardees were more likely to stay in the hematology-oncology field than national minority averages, with 14.4% of medical students and 88.5% of early-career
Safety, Ergonomics and Patient Centered Point-of-Care Ultrasound.
Med Clin North Am
January 2025
Sonography, University of Oklahoma Health Sciences Center, 4502 East 41st Street, Room 2D25, Tulsa, OK 74135, USA.
Ultrasound imaging is a safe diagnostic tool that has become ubiquitous, in part due to its portability, effectiveness, and safety record. The latter is aided be adherence to regulatory limits, safety guidelines, and the "as low as reasonably achievable" principle. Operators receive feedback on potential tissue heating and mechanical effects through output display standard that shows the thermal index and mechanical index.
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