Single-Cell RNA Sequencing in Ovarian Cancer: Current Progress and Future Prospects.

Ovarian cancer is one of the most prevalent gynaecological malignancies. The rapid development of single-cell RNA sequencing (scRNA-seq) has allowed scientists to use this technique to study ovarian cancer development, heterogeneity, and tumour environment. Although multiple original research articles have reported the use of scRNA-seq in understanding ovarian cancer and how therapy resistance occurs, there is a lack of a comprehensive review that could summarize the findings from multiple studies.

Effectiveness of custom-designed pointed laser light for teaching intraoral radiographic technique to undergraduate students: A comparative study.

Objectives: Intraoral periapical radiographic techniques are mandatory exercises taught to undergraduate students during their training. The key challenges encountered while teaching the bisecting angle technique (BAT) include correctly positioning the X-ray cone and adjusting the central X-ray beam to the tooth of interest. To address this, a custom-designed pointed laser light (CDPLL) was fabricated and attached to the X-ray cone.

Temporal patterns in Malaysian rainforest soundscapes demonstrated using acoustic indices and deep embeddings trained on time-of-day estimationa).

Rapid urban development impacts the integrity of tropical ecosystems on broad spatiotemporal scales. However, sustained long-term monitoring poses significant challenges, particularly in tropical regions. In this context, ecoacoustics emerges as a promising approach to address this gap.

Recent Advances in Biosensors Based on Hybridization Chain Reaction and Silver Nanoclusters.

Hybridization chain reaction (HCR) and DNA-templated silver nanoclusters (AgNCs) have emerged as powerful tools in biosensing. HCR enables cascade amplification through programmable DNA interactions, while DNA-AgNCs serve as transducing units with unique fluorogenic and electrochemical properties. Integrating these components into a hybrid sensor could significantly enhance sensing capabilities across various fields.

Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances.

Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting the expressions and activities of their downstream targets post-transcriptionally, dysregulations of miRNAs can alter different oncogenic signalling pathways, mediating liposarcoma progression.

Retraction notice to "Air-liquid interface cultivation of Navicula incerta using hollow fiber membranes"[Chemosphere 307 (2022) 135625].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Retraction notice to "Modified poly(vinylidene fluoride) nanomembranes for dye removal from water - A review" [Chemosphere 322 (2023) 138152].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Digital monitoring of medication safety in children: an investigation of ADR signalling techniques in Malaysia.

Background: Digital solutions can help monitor medication safety in children who are often excluded in clinical trials. The lack of reliable safety data often leads to either under- or over-dose of medications during clinical management which make them either not responding well to treatment or susceptible to adverse drug reactions (ADRs).

Aim: This study investigated ADR signalling techniques to detect serious ADRs in Malaysian children aged from birth to 12 years old using an electronic ADRs' database.

NeuroPAIN app: Usefulness of a mobile pain application evaluation system for children with cerebral palsy.

Objectives: Children with cerebral palsy (CP) can experience a substantial amount of pain. Effective pain management hinges on precise and prompt assessment. We designed a mobile-based application NeuroPAIN app to monitor pain among children with CP.

Comparison of the techniques for isolating immunoassay-suitable proteins from heterogeneous fecal samples.

Immunoassays could provide valuable insights into disease biomarkers and gut health by measuring fecal proteins. However, reliably isolating intact proteins from feces is challenging due to its heterogeneous and variable composition. This paper aims to review and compare different methods for extracting proteins from fecal samples to make them suitable for immunoassay analysis.

Associations Between Big-Five Personality Traits and Attitudes and Perception Towards Health Behaviours.

Despite efforts to promote exercise and healthy diets, global prevalence of obesity continues to rise. This pervasiveness of obesity is alarming as it is a key contributing factor of ischemic heart disease, a leading cause of death worldwide. The issue of obesity is exacerbated in Malaysia, where 50.

Transforming food environments: a global lens on challenges and opportunities for achieving healthy and sustainable diets for all.

Food environments are rapidly changing globally, both in developed and developing contexts, contributing to poor dietary habits and environmental concerns. As a result, more than 80% of countries in the world face different forms of malnutrition, while the environment faces further degradation due to unsustainable production and consumption patterns. Understanding food environments in diverse settings via a global lens is critical for facilitating the global transition to sustainable and healthy food environments.

Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery.

Small interfering RNAs (siRNA) technology has emerged as a promising therapeutic tool for human health conditions like cancer due to its ability to regulate gene silencing. Despite FDA-approved, their delivery remains localized and limiting their systemic use. This study used single-walled carbon nanotubes (SWNTs) functionalized with polyethylene glycolated (PEGylated) phospholipids (PL-PEG) derivatives for systemic siRNA delivery.

Evaluation of multiple breast cancer polygenic risk score panels in women of Latin American heritage.

Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European and Asian ancestry, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L specific variants among self-reported H/L women.

Advancements in Acoustic Cavitation Modelling: Progress, Challenges, and Future Directions in Sonochemical Reactor Design.

This review provides a comprehensive overview of ultrasonic wave propagation, with a primary focus on high-power ultrasound systems where cavitation bubbles are likely to occur. The review is structured to guide readers through the historical development of cavitation models, from early works such as the Rayleigh-Plesset equation to more advanced numerical approaches. It explores the dynamics of cavitation bubbles, their physical effects, and the key factors influencing bubble formation, growth, and collapse.

Perspectives of Malaysian community pharmacists on challenges and barriers to smoking cessation programme: a qualitative study.

Objectives: Smoking remains a significant public health concern, necessitating effective smoking cessation interventions. This study explores the barriers community pharmacists face in delivering smoking cessation services in Malaysia and potential solutions to improve their contribution to public health.

Methods: This qualitative study employed purposive and snowball sampling to recruit community pharmacists in Malaysia.

Antibacterial potency of mid-polar extracts obtained from Malaysian plant Parkia speciosa against human pathogenic bacteria.

Background And Objectives: Plants contain a wide variety of bioactive compounds, which have attracted the interest of researchers in finding novel sources of natural medicine. In the following paper, we aim to evaluate the antibacterial potential of extract fractions associated with Parkia speciosa pods and beans against human pathogenic bacteria.

Methods: Antimicrobial activity was determined with disc diffusion and broth microdilution assays against eight skin colonising microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia followed by further fractionation of the pods ethyl acetate fraction by column chromatography along with preparative thin-layer chromatography.

Comparative efficacy of extract delivery PEG--PCL, niosome, and their combination against genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity.

Background: spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous amebic encephalitis. is a native tree in Malaysia, and its extracts possess a broad range of biological activities.

Exploring feature sparsity for out-of-distribution detection.

Out-of-distribution (OOD) detection is a crucial problem in practice, especially, for the safe deployment of machine learning models in industrial settings. Previous work has used free energy as a score function and proposed a fine-tuning method that utilized OOD data in the training phase of the classification model, which achieves a higher performance on the OOD detection task compared with traditional methods. One key drawback, however, is that the loss function parameters are highly dependent on involved datasets, which means it cannot be dynamically adapted and implemented in others settings; in other words, the general ability of the energy score is considerably limited.

Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet?

Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants).