Psychometric properties of Farsi version of Demoralization Scale-II (DS-II) in Iranian cancer patients.

Objectives: Demoralization, a prevalent form of psychological distress, significantly impacts patient care, particularly in terminally ill individuals, notably those diagnosed with cancer. This study aimed to assess psychometric properties of Farsi version of Demoralization Scale-II (DS-II) in Iranian cancer patients.

Methods: This study was descriptive-analytical cross-sectional research.

Magnetic Resonance Imaging Features for Distinguishing High-Grade From Low-Grade Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis.

Soft tissue sarcomas are malignant tumors characterized by heterogeneity and are associated with a high mortality rate. Histopathological grading is considered a pivotal factor in prognostication and treatment planning. While core needle biopsy exhibits high accuracy in determining tumor histology, it fails in some cases, potentially misclassifying high-grade tumors as low-grade.

Spectroelectrochemical insights into the intrinsic nature of lead halide perovskites.

Lead halide perovskites have emerged as a new class of semiconductor materials with exceptional optoelectronic properties, sparking significant research interest in photovoltaics and light-emitting diodes. However, achieving long-term operational stability remains a critical hurdle. The soft, ionic nature of the halide perovskite lattice renders them vulnerable to various instabilities.

Conditional neural field latent diffusion model for generating spatiotemporal turbulence.

Eddy-resolving turbulence simulations are essential for understanding and controlling complex unsteady fluid dynamics, with significant implications for engineering and scientific applications. Traditional numerical methods, such as direct numerical simulations (DNS) and large eddy simulations (LES), provide high accuracy but face severe computational limitations, restricting their use in high-Reynolds number or real-time scenarios. Recent advances in deep learning-based surrogate models offer a promising alternative by providing efficient, data-driven approximations.

Sustained impacts of the COVID-19 pandemic on medical student learning and well-being in rural Australia: findings from a repeated national multicentre survey.

Objective: The impact of COVID-19 on medical students has predominantly been assessed by one-off survey studies at the pandemic onset. This national study investigated the sustained impacts of the COVID-19 pandemic on medical students' rural clinical placement learning and well-being.

Design: Repeated cross-sectional survey design.

Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer.

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objectives To identify and estimate the prognostic value of molecular biomarkers as predictors of pathological complete response to neoadjuvant chemoradiotherapy in people with locally advanced rectal cancer. summarises the review question in population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format.

International cross-sectional survey on current and updated definitions of intra-abdominal hypertension and abdominal compartment syndrome.

Background: The Abdominal Compartment Society (WSACS) established consensus definitions and recommendations for the management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in 2006, and they were last updated in 2013. The WSACS conducted an international survey between 2022 and 2023 to seek the agreement of healthcare practitioners (HCPs) worldwide on current and new candidate statements that may be used for future guidelines.

Methods: A self-administered, online cross-sectional survey was conducted under the auspices of the WSACS to assess the level of agreement among HCPs over current and new candidate statements.

Socio-spatial analysis of Australian residential care facilities: A case study of traditional, medium, and small household models.

While it is imperative to develop building design innovation to adapt to new care models and organisational processes in residential care facilities, there is a lack of research evidence on the interplay between design and resident lived experience, particularly when examined through a building design lens. This study aims to explore the building design factors that contribute to residents' quality of life (QoL), and thus, their ability to find home. The research objectives are to: 1) document and analyse the layout and spatial design of three different typologies (Traditional, Medium, and Small Household models) against key QoL themes and the residents' everyday lived use and sense of feeling at home; and 2) compare the architectural, layout, and lived use of the three typologies through a socio-spatial lens.

TIMESS a power analysis tool to estimate the number of locations and repeated measurements for seasonally and clustered mosquito surveys.

Every day, hundreds of mosquito surveys are carried out around the world to inform policy and management decisions on how best to reduce or prevent the burden of mosquito-borne disease or mosquito nuisance. These surveys are usually time consuming and expensive. Mosquito surveillance is the essential component of vector management and control.

Measuring Growth, Resistance, and Recovery after Artemisinin Treatment of Plasmodium falciparum in a single semi-high-throughput Assay.

Background: Artemisinin partial resistance (ART-R) has spread throughout Southeast Asia and mutations in , the molecular marker of resistance, are widely reported in East Africa. Effective assays and robust phenotypes are crucial for monitoring populations for the emergence and spread of resistance. The recently developed extended Recovery Ring-stage Survival Assay used a qPCR-based readout to reduce the labor intensiveness for phenotyping of ART-R and improved correlation with the clinical phenotype of ART-R.

Models of DEIB: Part I - Approaches to Inclusion from Other Health Professions for Consideration by Dentistry.

This article represents a prologue of the discussion of the article "Models of DEIB: Part II-Exploring Models of Inclusion from other Health Professions for Dentistry". It explores existing practices and philosophies from other disciplines that could be applied toward creating environments of inclusion and belonging in dentistry. The primary focus here is to provide an opportunity for the dental profession to leverage knowledge and experiences from other health professions to enhance and expand inclusion efforts and provide enhance engagement at all levels.

Socio-hydrological lock-in; an emergent phenomenon in the face of anthropogenic drought.

This study investigates the drought of three major terminal lakes: Great Salt Lake, Salton Sea, and Lake Urmia, driven by socio-hydrological lock-in-a phenomenon characterized by feedback loops between human activities and environmental processes. Previous research has linked this drying to socio-hydrological lock-in, where rational actions by individuals collectively lead to suboptimal outcomes, exacerbating water scarcity and ecological degradation. Despite existing studies, a critical knowledge gap remains in understanding how these feedback mechanisms operate across different socio-economic and ecological contexts.

Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase.

Antibiotic resistance in bacteria is a major global health concern. The wide spread of carbapenemases, bacterial enzymes that degrade the last-resort carbapenem antibiotics, is responsible for multidrug resistance in bacterial pathogens and has further significantly exacerbated this problem. is one of the leading nosocomial pathogens due to the acquisition and wide dissemination of carbapenem-hydrolyzing class D β-lactamases, which have dramatically diminished available therapeutic options.

Community-associated methicillin-resistant in the Kimberley region of Western Australia, epidemiology and burden on hospitals.

This study presents surveillance data from 1 July 2003 to 30 June 2023 for community-associated methicillin-resistant (CA-MRSA) notified in the Kimberley region of Western Australia (WA) and describes the region's changing CA-MRSA epidemiology over this period. A subset of CA-MRSA notifications from 1 July 2003 to 30 June 2015 were linked to inpatient and emergency department records. Episodes of care (EOC) during which a positive CA-MRSA specimen was collected within the first 48 hours of admission and emergency presentations (EP) during which a positive CA-MRSA specimen was collected on the same day as presentation were selected and analysed further.

The Existence of an Intra-Amniotic Microbiome: Assessing a Controversy.

The existence of intra-amniotic and placental microbiomes during pregnancy has been the source of considerable debate, with research yielding conflicting evidence. This study evaluated investigations into the putative presence of these microbiomes in healthy pregnancies by identifying design and data interpretation issues, particularly concerning contamination in samples with low-density bacterial DNA. Positive findings from diverse populations suggest a consistent presence of microbiota in the intra-amniotic space.

The J Domain Proteins of , a Zoonotic Malaria Parasite of Humans.

is a zoonotic form of human malaria, the pathology of which is poorly understood. While the J domain protein (JDP) family has been extensively studied in , and shown to contribute to malaria pathology, there is currently very limited information on the JDPs (PkJDPs). This review provides a critical analysis of the literature and publicly available data on PkJDPs.

Proportional Trends in Pediatric Opioid Prescribing Between 2005 and 2016 by Age Group, Sex, Ethnicity, Race, Language, and Payer Status from a Large Children's Hospital in the Southwest United States.

Background/objectives: Prescription opioid use before adulthood is typically effective for acute pain control and is also associated with adverse short- and long-term consequences.

Methods: This study examined pediatric opioid prescribing trends over time across different age groups (early childhood, school age, adolescence, young adult) and sociodemographic subgroups (sex, ethnicity, race, language, payer type) from 2005 to 2016.

Results: Utilizing 42,020 first outpatient opioid prescriptions for youth aged 0-21 years from a large US children's hospital, this research found notable trends and disparities.

SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme.

Down syndrome (DS) is a multisystemic disorder that includes accelerated aging caused by trisomy 21. In particular, overexpression of cystathionine-β-synthase (CBS) is linked to excess intracellular hydrogen sulfide (HS), a mitochondrial toxin at higher concentrations, which impairs cellular viability. Concurrent overexpression of superoxide dismutase 1 (SOD1) may increase oxidative stress by generating excess hydrogen peroxide (HO) while also mitigating the toxic HS burden via a non-canonical sulfide-oxidizing mechanism.

Effect of Co Irradiation on Boehmite Dissolution in Caustic Solutions.

Here, we examine how radiation impacts the dissolution behavior of boehmite by subjecting dry nanoparticles of different sizes to Co γ radiation and subsequently analyzing their dissolution behavior in caustic solutions as a function of temperature. The measured kinetics show that irradiation with an amount 228.24 Mrad significantly slows the dissolution rate, particularly for smaller sizes at lower temperatures.

Designing Phenolphthalein-Based Adsorptive Membranes for the High-Affinity, High-Capacity Capture of Contaminants from Water.

The selective removal of solutes is crucial for ensuring a sustainable water supply, recovering resources, and cost-effective biomanufacturing. Adsorptive membranes are promising in this regard due to their rapid mass transfer and low energy demands. However, state-of-the-art adsorptive membranes offer limited pore sizes and surface chemistries.