Early midlife ovarian removal is associated with lower posterior hippocampal function.

Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.

Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.

Technology use in long-term care during the COVID-19 pandemic: A qualitative study of paid employees' experiences in Western Canada.

Background: During the COVID-19 pandemic, governments across the world implemented processes and policies to limit the spread of COVID-19, especially in long-term care (LTC) homes. This led to changes in technology use for persons living in LTC homes, their families and friends, as well as the paid workforce dedicated to caring for them.

Objective: The study describes the role of technology and its impact on the experiences of LTC staff working in northern and rural areas in Western Canada during COVID-19.

Native Valve and Native Neo-Sinus Remodeling Following Transcatheter Aortic Valve Replacement.

Background: Transcatheter aortic valve replacement (TAVR) pushes aside the diseased native aortic valve and creates a native neo-sinus bordered by the aortic root wall and the displaced native valve. There are limited data on the progression of native valve disease post-TAVR and no previous analysis of the native neo-sinus.

Methods: Native aortic valves and native neo-sinus explants obtained post-TAVR were evaluated histologically (hematoxylin and eosin, Movat pentachrome, and Martius Scarlet Blue stains) and by immunohistochemistry (TGF-β1 [transforming growth factor-beta 1], FAP [fibroblast activation protein], and ALP [alkaline phosphatase]) to assess disease mechanisms.

Successful Aging across Middle vs High-Income Countries: An Analysis of the Role of eHealth Literacy Associated with Loneliness and Wellbeing.

Background And Objectives: "Successful aging" concerns the process of growing older while maintaining physical, cognitive, and social wellbeing, emphasizing independence for overall satisfaction and quality of life. We investigate the impact of e-health literacy on reducing loneliness and sustaining wellbeing during the pandemic, comparing middle- and high-income countries.

Research Design And Methods: Online surveys were conducted between April 4, 2020, and September 30, 2021, collecting responses (N=2091) from medium- and high-income countries in Europe, Asia, and North America.

Green solvent-based extraction of cellulose from hemp bast fibers: From treatment efficacy to characterizations and optimization.

This study assessed the efficacy of deep eutectic solvents (DESs) as green solvents for cellulose extraction from hemp bast fiber. Three DES mixtures were applied, and the combination of choline chloride and glycerol was selected for further experimentation due to its superior performance. The impact of four key parameters- treatment time, treatment temperature, DES-to-hemp ratio, and glycerol-to-choline chloride ratio was analyzed using Central-Composite Design (CCD) within response surface methodology (RSM) to optimize cellulose extraction.

Alcohol consumption and mortality among Canadian drinkers: A national population-based survival analysis (2000-2017).

Introduction: Alcohol contributes significantly global disease burden. Over 50 countries, including Canada, have established low-risk drinking guidelines to reduce alcohol-related harm. Canada's Guidance on Alcohol and Health (CGAH) was released in 2023.

Intrinsic and environmental drivers of pairwise cohesion in wild Canis social groups.

Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.

Directed Forgetting and the Production Effect.

The item-based directed-forgetting effect is explained as a difference in how strongly people encode remember-cued over forget-cued targets. In contrast, the production effect is typically explained as a difference in the distinctiveness of the memory of produced over unproduced targets. The procedural alignment of the two effects - directing participants to remember or forget, produce or not - coupled with their different theoretical explanations (i.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Global rarity of high-integrity tropical rainforests for threatened and declining terrestrial vertebrates.

Structurally intact native forests free from major human pressures are vitally important habitats for the persistence of forest biodiversity. However, the extent of such high-integrity forest habitats remaining for biodiversity is unknown. Here, we quantify the amount of high-integrity tropical rainforests, as a fraction of total forest cover, within the geographic ranges of 16,396 species of terrestrial vertebrates worldwide.

Beyond waste in agriculture: Feedstock characterization for thermochemical conversion based on potato above-ground biomass.

Agricultural residues represent a valuable opportunity to develop circular bioeconomic systems centered on biomass. Characterizing this type of biomass can alleviate the pressure on current biomass sources (e.g.

A rapid CAT transformation protocol and nuclear transgene expression tools for metabolic engineering in Cyanidioschyzon merolae 10D.

The eukaryotic red alga Cyanidioschyzon merolae 10D is an emerging algal host for synthetic biology and metabolic engineering. Its small nuclear genome (16.5 Mb; 4775 genes), low intron content (39), stable transgene expression, and capacity for homologous recombination into its nuclear genome make it ideal for genetic and metabolic engineering endeavors.

Bicultural peace pedagogy: opportunities and obstacles.

This article appreciates decolonization in education, positing bicultural pedagogy as peace pedagogy. It will encapsulate peace education, peace pedagogy, colonization, Indigenous rediscovery, and Indigenization of the curriculum (biculturalism) and then turn to the transformative practice of decolonization in education. The paper seeks to propose a conceptual bridging facet from five core Māori values: , and , to Indigenous pedagogy and, finally, to peace pedagogy.

Hydrophilic Metal-Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery.

For bridging the gap between biological and synthetic materials, the fusion of Metal-Organic Frameworks (MOFs) with biological entities has emerged as a revolutionary strategy in functional materials. In this context, our study introduces a novel structure wherein Bovine Serum Albumin (BSA), a robust and versatile protein, encapsulates zeolitic imidazolate framework-8 (ZIF-8), forming a protein-caged MOF. Highlighting the advantages of this innovative design, the protein-encapsulation enhances the stability and dispersity of ZIF-8, and aids in the synthesis of smaller-sized nanoparticles, crucial for size-impact performance applications.

Investigating the independent and synergistic associations between neighbourhood greenness and physical activity in relation to perceived mental health among adults in Canada.

The relationships among neighbourhood greenness, physical activity, and mental health are unclear; therefore, we examined the independent and synergistic associations between neighbourhood greenness and self-rated mental health among a nationally representative sample of urban-dwelling adults in Canada (18-79 years) from the 2007-2019 Canadian Health Measures Survey ( = 12,531). We assessed neighbourhood greenness using the Normalized Difference Vegetation Index within a 500-meter radius of participants' residential postal codes. We measured physical activity using accelerometers and determined adherence to the recommended 150-minutes of moderate-to-vigorous intensity physical activity (MVPA) per week.

The prevalence and risk factors of apathy among the Canadian long-term care residents with Alzheimer's disease and related dementias.

Background: Apathy is a prevalent and debilitating neuropsychiatric symptom among persons living with Alzheimer's disease and related dementias, particularly those residing in long-term care facilities (LTCF). Despite its profound effects on the quality of life for both residents and their caregivers, apathy remains underrecognized and poorly understood in the context of dementia care.

Objective: To investigate the prevalence and biopsychosocial characteristics of apathy among newly admitted residents with dementia in Canadian LTCF using an Apathy Index derived from the interRAI Minimum Data Set (MDS) 2.

A mixed-methods exploration of the Real-Time Virtual Support pathway Child Health Advice in Real-Time Electronically in Northwestern BC.

Objectives: To explore the implementation of a provincial virtual paediatric consulting service, Child Health Advice in Real-Time Electronically (CHARLiE), integrated into the paediatric on-call schedule in Northwestern British Columbia.

Methods: Healthcare providers in Northwestern British Columbia responded to a survey (n = 72) and participated in focus groups (n = 35) and key informant interviews (n = 4) to share their experiences engaging in a healthcare model that incorporated virtual paediatric consultants in lieu of in-person local paediatrician coverage over a 28-month period. Survey data was analyzed using descriptive statistics.

From marginal croplands to natural habitats: A methodological framework for assessing the restoration potential to enhance wild-bee pollination in agricultural landscapes.

Context: Intensive agriculture increases crop yields, but harms biodiversity and associated ecosystem services such as pollination. To sustain wild-bee pollination in intensive agricultural landscapes, a minimum of (semi-) natural habitat is needed in the vicinity of crop fields. However, restoration of (semi-) natural habitat is a challenge, especially when most land is allocated to commodity production.

Integrated optimization of marine oil spill response and liquid oily waste management using mathematical programming and evolutionary metaheuristic techniques.

Marine oil spill response is a time sensitive and complex task, in which the management of oily wastewater generated from response operations could be a bottleneck limiting the response capacity and efficiency. This study developed a multi-agent decision support system to effectively coordinate mechanical containment and recovery (MCR) of spilt oil and oily wastewater management (OWM) operations. The system aims to minimize the overall response time, cost, and the volume of weathered oil by applying evolutionary optimization, oil weathering process, and response operational agents.

A holistic approach to supporting death in the home: Implementation of a home hospice program in a northern community-A study protocol.

Introduction: To enhance support for individuals at end of life to die at home, a new community-driven home-based hospice program was developed-Home Hospice. This wholistic hospice care program, co-designed by hospice care staff, community end-of-life care providers, researchers, and health systems decision-makers, will provide around the clock care to clients and their families.

Methods And Analysis: This mixed methods study, guided by a process evaluation framework, will use secondary client and caregiver data collected as part of regular Home Hospice program processes, as well as primary interview data collected from caregivers at least three months post-death of the client and from hospice staff and volunteers involved in the Home Hospice program.

Check, Please! Supervisor-Learner Dyads Using "Checking" for Clinical Support During Indirect Supervision.

Background: Indirect supervision is essential for granting autonomy to learners. Sometimes referred to as leaving the learner "unsupervised," there is growing recognition that learners and supervisors engage in clinical support through ongoing interactions, albeit at a distance.

Objective: To understand how the complementary activities of asking for and providing clinical support at a distance come together as indirect supervision by identifying the natural language used between learners and supervisors.