6 results match your criteria: "University of North France[Affiliation]"
Early postoperative risk prediction of neurocognitive decline.
Br J Anaesth
April 2022
Inserm, CHU Lille, Universite Lille, Department of Biochemistry and Molecular Biology, Laboratory of Hormonology, Metabolism-Nutrition & Oncology (HMNO), Center of Biology and Pathology (CBP) Pierre-Marie Degand, CHRU Lille, EA 7364 RADEME, University of North France, Lille, France. Electronic address:
High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders.
Cells
September 2021
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, UCSF, San Francisco, CA 94143, USA.
Aseptic surgical trauma provokes the release of HMGB1, which engages the innate immune response after binding to pattern-recognition receptors on circulating bone marrow-derived monocytes (BM-DM). The initial systemic inflammation, together with HMGB1, disrupts the blood-brain barrier allowing penetration of CCR2-expressing BM-DMs into the hippocampus, attracted by the chemokine MCP-1 that is upregulated by HMGB1. Within the brain parenchyma quiescent microglia are activated and, together with the translocated BM-DMs, release proinflammatory cytokines that disrupt synaptic plasticity and hence memory formation and retention, resulting in postoperative cognitive decline (PCD).
View Article and Find Full Text PDFThe Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders.
Front Aging Neurosci
May 2021
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA, United States.
The aseptic trauma of peripheral surgery activates a systemic inflammatory response that results in neuro-inflammation; the microglia, the resident immunocompetent cells in the brain, are a key element of the neuroinflammatory response. In most settings microglia perform a surveillance role in the brain detecting and responding to "invaders" to maintain homeostasis. However, microglia have also been implicated in producing harm possibly by changing its phenotype from its beneficial, anti-inflammatory state (termed M2) into an injurious pro-inflammatory state (termed M1); it is likely that there are intermediates states between these polar phenotypes and some consider that a gradient exists with a number of intermediates, rather than a strict dichotomy between M1 and M2.
View Article and Find Full Text PDFPreoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study.
BMC Anesthesiol
November 2020
Inserm, CHU Lille, Univ Lille, Department of Biochemistry and Molecular Biology, Laboratory of Hormonology, Metabolism-Nutrition & Oncology (HMNO), Center of Biology and Pathology (CBP) Pierre-Marie Degand, CHRU Lille, EA 7364 RADEME, University of North France, Lille, France.
Background: Surgical interventions result in a postoperative rise in circulating inflammatory cytokines and high molecular group box protein 1 (HMGB1). Herein, the impact of a sedentary lifestyle and other age-related factors on the development of perioperative neurocognitive disorders (PND) following non-cardiac surgical procedures was assessed in an older (55-75 years-old) surgical population.
Methods: Prior to surgery, patients were asked questions regarding their sedentary behavior and daily habits.
Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias.
Biochimie
January 2020
Laboratory of Molecular Biology of the Gene, Department of Molecular Biology, ULB Immunology Research Center (UIRC), Free University of Brussels (ULB), Gosselies, Belgium.
Article Synopsis
- * Three clues suggest that secondary 3-MGAs may involve a common target in metabolism, a unique response to leucine testing, and the potential role of peroxisomes in HMG-CoA metabolism.
- * A proposed unifying theory indicates that mitochondrial dysfunction activates AMPK, redirecting metabolic processes to produce 3-MGA in peroxisomes, with insights coming from existing literature supporting this hypothesis.
L-Lactate-Based Improvement of Energetic Charge and Protection of Rat Liver.
Liver Transpl
October 2019
INSERM, Laboratory of Molecular Biology and Biochemistry, Hormonology/Metabolism/Nutrition/Oncology, Center of Biology and Pathology, Centre Hospitalier Universitaire Lille, EA 7364 RADEME, University of North France, Lille, France.