A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort.

Background: As machine learning becomes increasingly utilized in orthopaedic clinical research, the application of machine learning methodology to cohort data from the Multicenter ACL Revision Study (MARS) presents a valuable opportunity to translate data into patient-specific insights.

Purpose: To apply novel machine learning methodology to MARS cohort data to determine a predictive model of revision anterior cruciate ligament reconstruction (rACLR) graft failure and features most predictive of failure.

Study Design: Cohort study; Level of evidence, 3.

"Utility of social vulnerability index in trauma: A systematic review".

Introduction: Traumatic injuries remain a leading cause of mortality across age groups. Despite advancements in medical care, addressing the broader determinants of health is essential. Social determinants of health (SDOH), including socioeconomic factors, play a crucial role in patient outcomes.

Impact of using dosing criteria to refine pharmacogenomic clinical decision support for tricyclic antidepressants.

Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Vanishing bile duct syndrome: a sequela of temozolomide and levetiracetam-induced cholestatic liver injury.

Temozolomide (TMZ)-levetiracetam (LEV) combination therapy in glioblastoma management is gradually becoming a mainstay treatment given its superior effect compared with TMZ monotherapy. While there have been previous cases of hepatotoxicity, there are no prior reports of vanishing bile duct syndrome (VBDS) associated with TMZ-LEV combination use. This case report details a male in his 50s who had recently completed TMZ and LEV for right frontal lobe glioblastoma.

The role of anterolateral complex surgery and slope-reducing osteotomies in revision ACL reconstructions: a narrative review.

Background And Objective: Anterior cruciate ligament reconstruction (ACLR) failures occur for various reasons including residual laxity, untreated concomitant injuries, poor graft quality, and high tibial slope. Various additional procedures can help to decrease revision ACLR failures including anterolateral complex (ALC) procedures and slope-reducing osteotomies for patients with high tibial slopes. This narrative review aims to review the literature on the roles of ALC augmentation procedures and slope-reducing osteotomies in the setting of patients undergoing revision ACLRs.

Transcatheter Aortic Valve Replacement in Patients With Geographic and Socioeconomic Vulnerabilities.

Background: Transcatheter aortic valve replacement (TAVR) is an established treatment for patients with severe aortic stenosis (AS). It remains unclear whether disparities exist in rural or socially vulnerable populations undergoing TAVR. This study assessed whether outcomes differ based on geographic location or vulnerability of patients undergoing TAVR.

Heart rate variability during pregnancy moderates the impact of depressive symptoms on fetal growth.

Depression occurs in up to 13 % of all pregnancies and is associated with adverse pregnancy outcomes. However, the literature regarding associations between depression and lower birth weight or fetal growth has been inconsistent. Here, we consider if high frequency heart rate variability (HF-HRV) may moderate the association between depression and birth weight.

Knockdown of Keratin 6 Within Arsenite-Transformed Human Urothelial Cells Decreases Basal/Squamous Expression, Inhibits Growth, and Increases Cisplatin Sensitivity.

Urothelial carcinoma (UC) is prevalent, especially in elderly males. The high rate of recurrence, treatment regime, and follow-up monitoring make UC a global health and economic burden. Arsenic is a ubiquitous toxicant that can be found in drinking water, and it is known that exposure to arsenic is associated with UC development.

Infections and Patient Satisfaction in WALANT Hand Surgery in a Hospital Procedure Room.

Wide-awake hand surgery has allowed many hand procedures to be moved out of the operating room and into minor procedure rooms while increasing efficiency, maintaining safety, and reducing both patient and hospital costs. The goal of this study was to evaluate patient satisfaction and postoperative complications of wide-awake local anesthesia with no tourniquet procedures performed in a community-based hospital procedure room. A total of 786 patients underwent 948 elective hand procedures in a hospital procedure room.

Access to Healthcare for Appendicitis Patients in the United States Based on Insurance Coverage.

Introduction: Health insurance plays a crucial role in ensuring access to healthcare services, addressing affordability concerns. Insurance options have varying wait times and acceptance challenges, which can greatly impact patients in emergency conditions, such as appendicitis. This study aims to find out the healthcare access disparities for appendicitis patients in states with low Medicaid coverage.

Blood pressure variability associated with falls in nursing home residents.

Background: High variations in serially measured blood pressures (BPs) portend a variety of adverse clinical events including dementia, cardiovascular sequelae and frailty. In this study, systolic blood pressure variability (BPV) was examined for its association with fall frequency and time to next fall among older adults living in nursing homes.

Methods: BP values and falls over time were extracted from medical records of nursing home residents aged ≥65 years over a 10-month period.

A naturalistic assessment of the relationship between negative affect and loss of control eating over time following metabolic and bariatric surgery.

Disordered eating behavior has been linked to suboptimal weight outcomes following metabolic and bariatric surgery (MBS), thereby threatening the most efficacious treatment for severe obesity. While up to 40% of patients may experience loss of control (LOC) eating following MBS, mechanisms driving this behavior are not fully understood. Preliminary evidence suggests that high levels of negative affect (NA) in the moment prompt LOC eating post-MBS; however, it remains unclear whether this momentary relationship is stable or changes over the first several years following surgery.

The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation.

Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations with drug response, pharmacogenetic testing has not been widely implemented into clinical practice. Among the barriers to broad implementation are limited guidance for how to successfully integrate testing into clinical workflows and limited data on outcomes with pharmacogenetic implementation in clinical practice.

Impedance Spectroscopy Measures of Whole and Segmental Skeletal Muscle Quantity Associated With Strength and Power in Collegiate Ice Hockey Players.

Otremba, JR, Heesch, AJ, Morgan, RM, Poolman, MA, Schindler, GD, and Fitzgerald, JS. Bioelectrical impedance spectroscopy measures of whole and segmental skeletal muscle quantity associated with strength and power in collegiate ice hockey players. J Strength Cond Res XX(X): 000-000, 2024-Bioelectrical impedance spectroscopy (BIS) is a promising monitoring tool for body water compartment assessment, particularly intracellular water (ICW), in which acute decreases are associated with increased muscle damage and reduced function, and chronic changes are associated with muscle quantity.