A rapid one-step synthesis of silver and copper coordinated chlorine functionalized fullerene nanoparticles with enhanced antibacterial activity.

Nanoparticle modification demonstrates a remarkable synergetic effect in combating bacteria, particularly resistant bacteria, enhancing their efficacy by simultaneously targeting multiple cellular pathways. This approach positions them as a potent solution against the growing challenge of antimicrobial-resistant (AMR) strains. This research presents an investigation into the synthesis, characterization, and antibacterial evaluation of silver-coordinated chloro-fullerenes nanoparticles (Ag-C-Cl) and copper-coordinated chloro-fullerenes nanoparticles (Cu-C-Cl).

Multiconfigurational actinide nitrides assisted by double Möbius aromaticity.

Understanding the bonding nature between actinides and main-group elements remains a key challenge in actinide chemistry due to the involvement of f orbitals. Herein, we propose a unique "aromaticity-assisted multiconfiguration" (AAM) model to elucidate the bonding nature in actinide nitrides (AnN, An = Ac, Th, Pa, U). Each planar four-membered AnN with equivalent An-N bonds possesses four delocalized π electrons and four delocalized σ electrons, forming a new family of double Möbius aromaticity that contributes to the molecular stability.

Compartmentalized CRISPR Reactions (CCR) for High-Throughput Screening of Guide RNA Potency and Specificity.

CRISPR ribonucleoproteins (RNPs) use a variable segment in their guide RNA (gRNA) called a spacer to determine the DNA sequence at which the effector protein will exhibit nuclease activity and generate target-specific genetic mutations. However, nuclease activity with different gRNAs can vary considerably, in a spacer sequence-dependent manner that can be difficult to predict. While computational tools are helpful in predicting a CRISPR effector's activity and/or potential for off-target mutagenesis with different gRNAs, individual gRNAs must still be validated in vitro prior to their use.

Invisible targets: Conceptualizing U.S. Latine youth's exposure to family-level vicarious racism.

Vicarious exposure to discrimination can result in multiple negative outcomes in youth. In this article, we offer a conceptual model that articulates the intersecting contextual factors and potential moderators for U.S.

COVID-19 and individual performance in global virtual teams: The role of self-regulation and individual cultural value orientations.

Since the onset of the COVID-19 pandemic, global virtual teams (GVTs) have become increasingly important. Drawing on conservation of resources theory and self-regulation theory, we examined the mechanism and process underlying individuals' performance in GVTs in this specific situation. We posit that the local severity of the pandemic has a negative effect on individuals' performance in GVTs and that self-regulation functions as a coping mechanism in times of pandemic-related ambient stress, reducing its negative effect on performance.

Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy.

Regulation of the apoptotic pathway plays a critical role in inducing tumor cell death and circumventing drug resistance. Survivin protein is the strongest inhibitor of apoptosis found so far. It is highly expressed in several cancers and is a promising target for cancer therapy.

Integrating trauma-informed care into career counseling: A response to COVID-19 job loss for Black, indigenous, and people of color.

The drastic increase among the U.S. unemployment rate led to increased trauma among those who lost their job as a result of the global COVID-19 pandemic.

Impacts of state COVID-19 reopening policy on human mobility and mixing behavior.

This study quantifies the effect of the 2020 state COVID economic activity reopening policies on daily mobility and mixing behavior, adding to the economic literature on individual responses to public health policy that addresses public contagion risks. We harness cellular device signal data and the timing of reopening plans to provide an assessment of the extent to which human mobility and physical proximity in the United States respond to the reversal of state closure policies. We observe substantial increases in mixing activities, 13.

Heat Safety in the Workplace: Modified Delphi Consensus to Establish Strategies and Resources to Protect the US Workers.

The purpose of this consensus document was to develop feasible, evidence-based occupational heat safety recommendations to protect the US workers that experience heat stress. Heat safety recommendations were created to protect worker health and to avoid productivity losses associated with occupational heat stress. Recommendations were tailored to be utilized by safety managers, industrial hygienists, and the employers who bear responsibility for implementing heat safety plans.

Resonance-assisted/impaired anion-π interaction: towards the design of novel anion receptors.

Substituents alter the electron density distribution in benzene in various ways, depending on their electron withdrawing and donating capabilities, as summarized by the empirical Hammett equation. The change of the π electron density distribution subsequently impacts the interaction of substituted benzenes or other cyclic conjugated rings with anions. Currently the design and synthesis of conjugated cyclic receptors capable of binding anions is an active field due to their applications in the sensing and removal of environmental contaminants and molecular recognition.

The Authors Respond.

No outside funding supported this study. The authors have nothing to disclose.

A sol-gel synthesis to prepare size and shape-controlled mesoporous nanostructures of binary (II-VI) metal oxides.

A base-catalyzed sol-gel approach combined with a solvent-driven self-assembly process at low temperature is augmented to make manganese oxide (MnO), copper oxide (CuO), and magnesium hydroxide (Mg(OH)) nanostructures with size- and shape-controlled morphologies. Nanostructures of MnO with either hexagonal, irregular particle, or ribbon shape morphologies with an average diameter ranged from 100 to 200 nm have been prepared in four different solvent types. In all morphologies of MnO, the experimental XRD patterns have indexed the nanocrystal unit cell structure to triclinic.

Synthesis of a novel hexaazatriphenylene derivative for the selective detection of copper ions in aqueous solution.

A hexaazatriphenylene (HAT) derivative, naphtho[2,3-h]naphtho[2',3':7,8]quinoxalino[2,3-]naphtho[2',3':7,8]quinoxalino[2,3-]phenazine-5,10,15,20,25,30-hexaone (NQH) was synthesized, characterized, and found to have novel properties in being selective toward the detection of copper (Cu) ions. The capability of NQH to be employed as a colorimetric, chemo-fluorescence and electrochemical sensor for the detection of Cu was demonstrated by performing UV-Vis absorbance, fluorescence intensity, and cyclic voltammetry (CV) measurements. The interaction between NQH and Cu was initially observed with an obvious color change from yellow to brown upon the addition of Cu ions to NQH.

Pollinator parasites and the evolution of floral traits.

The main selective force driving floral evolution and diversity is plant-pollinator interactions. Pollinators use floral signals and indirect cues to assess flower reward, and the ensuing flower choice has major implications for plant fitness. While many pollinator behaviors have been described, the impact of parasites on pollinator foraging decisions and plant-pollinator interactions have been largely overlooked.

Environmental factors affect the distribution of two fungal endophyte species inhabiting a common host grove bluegrass ().

Aim: The endophyte , with known insecticidal properties, is found in a majority of populations across a latitudinal gradient from North Carolina to New York. A second endophyte, var. , with known insect-deterring effects, is limited to a few populations in Pennsylvania.

Band gap engineered zinc oxide nanostructures a sol-gel synthesis of solvent driven shape-controlled crystal growth.

A reliable sol-gel approach, which combines the formation of ZnO nanocrystals and a solvent driven, shape-controlled, crystal-growth process to form well-organized ZnO nanostructures at low temperature is presented. The sol of ZnO nanocrystals showed shape-controlled crystal growth with respect to the solvent type, resulting in either nanorods, nanoparticles, or nanoslates. The solvothermal process, along with the solvent polarity facilitate the shape-controlled crystal growth process, augmenting the concept of a selective adhesion of solvents onto crystal facets and controlling the final shape of the nanostructures.

Natural selection contributes to geographic patterns of thermal plasticity in .

A long-standing debate in evolutionary biology concerns the relative importance of different evolutionary forces in explaining phenotypic diversification at large geographic scales. For example, natural selection is typically assumed to underlie divergence along environmental gradients. However, neutral evolutionary processes can produce similar patterns.

Evaluation of an exercise programme for post-bariatric surgery patients: views of participants.

Objective: Exercise programmes typically are evaluated with fitness assessments and psychological survey measures but seldom include participants' insights. The purpose of this study was to evaluate the benefits, facilitators and barriers of a 12-week exercise programme for post-bariatric surgery patients from the participants' perspective.

Method: Over a 2-year period, 20 patients recently having undergone bariatric surgery completed a 12-week programme that included participation in structured exercise and in focus groups designed to supplement standard evaluation data and provide insight into participants' views.

Dynamical facilitation of the ideal free distribution in nonideal populations.

The ideal free distribution (IFD) requires that individuals can accurately perceive density-dependent habitat quality, while failure to discern quality differences below a given perception threshold results in distributions approaching spatial uniformity. Here, we investigate the role of population growth in restoring a nonideal population to the IFD. We place a simple model of discrete patch choice under limits to the resolution by which patch quality is perceived and include population growth driven by that underlying quality.

Separating the effects of water quality and urbanization on temperate insectivorous bats at the landscape scale.

Many local scale studies have shown that bats respond to water quality degradation or urbanization in a species-specific manner. However, few have separated the effects of urbanization versus water quality degradation on bats, in single city or single watershed case studies. Across North Carolina, USA, we used the standardized North American Bat Monitoring Program mobile transect protocol to survey bat activity in 2015 and 2016 at 41 sites.

American Sign Language Syntax and Analogical Reasoning Skills Are Influenced by Early Acquisition and Age of Entry to Signing Schools for the Deaf.

Failing to acquire language in early childhood because of language deprivation is a rare and exceptional event, except in one population. Deaf children who grow up without access to indirect language through listening, speech-reading, or sign language experience language deprivation. Studies of Deaf adults have revealed that late acquisition of sign language is associated with lasting deficits.